Clinical Trial of Brentuximab Vedotin in Classical Hodgkin Lymphoma

PHASE2TerminatedINTERVENTIONAL
Enrollment

255

Participants

Timeline

Start Date

January 28, 2019

Primary Completion Date

November 7, 2022

Study Completion Date

August 23, 2024

Conditions
Hodgkin Lymphoma
Interventions
DRUG

brentuximab vedotin

1.2 mg/kg by IV infusion

DRUG

doxorubicin

25 mg/m\^2 by IV infusion

DRUG

vinblastine

6 mg/m\^2 by IV infusion

DRUG

dacarbazine

375 mg/m\^2 by IV infusion

DRUG

G-CSF

Granulocyte colony stimulating factor (G-CSF) primary prophylaxis administered 24-36 hours after each dose of A+AVD

DRUG

nivolumab

240 mg by IV infusion

Trial Locations (76)

3002

Epworth Healthcare, Victoria

3168

Monash Medical Centre, Clayton

3350

Ballarat Regional Integrated Cancer Care, Ballarat

5000

Royal Adelaide Hospital, Adelaide

10029

Mount Sinai Medical Center, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10126

Azienda Ospedaliera Citta della Salute e della Scienza di Torino, Torino

10577

Clinical Research Alliance - Abraham Mittelman, MD, LLC, Purchase

11590

Clinical Research Alliance - Morton Coleman, MD, Westbury

12208

New York Oncology Hematology, P.C., Albany

17007

Hospital Universitario de Girona Doctor Josep Trueta, Girona

22031

Virginia Cancer Specialists, PC, Fairfax

24153

Oncology and Hematology Assoc of SW VA DBA Blue Ridge Cancer Care, Salem

25123

Azienda Ospedaliera Spedali Civili di Brescia, Brescia

27100

IRCSS Policlinico San Matteo, Pavia

27157

Wake Forest Baptist Medical Center / Wake Forest University, Winston-Salem

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28222

Hospital Puerta de Hierro Majadahonda, Majadahonda

29425

Medical University of South Carolina/Hollings Cancer Center, Charleston

33011

Hospital Universitario Central de Asturias, Oviedo

33176

Miami Cancer Institute at Baptist Health, Inc., Miami

33705

Florida Cancer Specialists - North Region, St. Petersburg

37007

Hospital Clinico Universitario de Salamanca, Salamanca

37203

Tennessee Oncology-Nashville/Sarah Cannon Research Institute, Nashville

37920

University of Tennessee, Knoxville

43623

Toledo Clinic Cancer Center, Toledo

44106

University Hospitals Cleveland Medical Center, Cleveland

44195

Cleveland Clinic, The, Cleveland

45242

Oncology Hematology Care, Cincinnati

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

48201

Karmanos Cancer Institute / Wayne State University, Detroit

48202

Henry Ford Health System, Detroit

53100

Azienda Ospedaliera Universitaria Senese, Siena

55435

Minnesota Oncology Hematology P.A., Edina

60153

Cardinal Bernardin Cancer Center / Loyola University Medical Center, Maywood

60714

Illinois Cancer Specialists, Niles

61615

Illinois Cancer Care, Peoria

63110

Washington University in St Louis, St Louis

75028

Texas Oncology - Flower Mound, Flower Mound

75230

Texas Oncology - Medical City Dallas, Dallas

75702

Texas Oncology - Northeast Texas, Tyler

76104

Texas Oncology - Fort Worth 12th Avenue, Fort Worth

78234

Brooke Army Medical Center, Fort Sam Houston

78240

Texas Oncology - San Antonio Medical Center, San Antonio

78705

Texas Oncology - Austin Midtown, Austin

80012

Rocky Mountain Cancer Centers - Aurora, Aurora

80218

Cancer Centers of Colorado - Denver, Denver

80528

Poudre Valley Health System (PVHS), Fort Collins

80909

University of Colorado Health Memorial Hospital, Colorado Springs

81501

SCL Health - St. Mary's Hospital & Medical Center, Grand Junction

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

92708

Los Angeles Cancer Network / Compassionate Care Research Group, Fountain Valley

97213

Providence Portland Medical Center, Portland

97401

Willamette Valley Cancer Institute and Research Center, Eugene

98506

Vista Oncology Inc PS, Olympia

99336

Kadlec Clinic Hematology and Oncology, Kennewick

02114

Massachusetts General Hospital, Boston

02215

Beth Israel Deaconess Medical Center, Boston

08724

New Jersey Hematology Oncology Associates, LLC, Brick

07728

Regional Cancer Care Associates - Freehold, Freehold

07601

Hackensack University Medical Center, Hackensack

07731

Regional Cancer Care Associates - Howell, Howell Township

07960

Morristown Medical Center/ Carol G. Simon Cancer Center, Morristown

08060

Regional Cancer Care Associates - Mount Holly, Mount Holly

08876

Regional Cancer Care Associates - Central Jersey, Somerville

07871

Regional Cancer Care Associates - Sparta, Sparta

10549-3412

CareMount Medical Group, Mount Kisco

77030-4095

MD Anderson Cancer Center / University of Texas, Houston

98109-1023

Seattle Cancer Care Alliance / University of Washington, Seattle

500 05

Fakultni nemocnice Hradec Kralove-oddeleni klinicke hematologie, Hradec Králové

100 34

Fakultni Nemocnice Kralovske Vinohrady, Prague

30-727

Pratia MCM Krakow, Krakow

08003

Hospital del Mar, Barcelona

08035

Hospital Universitari Vall d'Hebron, Barcelona

08908

Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet), Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Seagen Inc.

INDUSTRY