Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease

NACompletedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

October 1, 2018

Primary Completion Date

June 2, 2023

Study Completion Date

June 2, 2023

Conditions
Amyotrophic Lateral Sclerosis (ALS)Neuromuscular Diseases
Interventions
OTHER

Acute Intermittent Hypoxia

AIH entails continuous breathing as the level of oxygen in the air is decreased, then returned to normal. Participants will alternate between breathing normal air and breathing hypoxic air (air that has less oxygen). Participants will complete a single 45 minute session of acute intermittent hypoxia (AIH). Breathing, muscle activity and heart activity will be monitored before, during and after the procedure. The intervals will last 1 minute each.

OTHER

Sham Acute Intermittent Hypoxia

Participants will complete the sham acute intermittent hypoxia, consisting of a single 45 minute session of breathing air with normal oxygen levels. All aspects of this procedure will otherwise be the same as for the AIH procedure. Breathing, muscle activity and heart activity will be monitored before, during and after the procedure.

Trial Locations (2)

32610

UF Clinical Research Center, Gainesville

32611

University of Florida, Gainesville

All Listed Sponsors
lead

University of Florida

OTHER

NCT03645031 - Acute Intermittent Hypoxia and Breathing in Neuromuscular Disease | Biotech Hunter | Biotech Hunter