Natural Versus Artificial Cycle for Frozen-Thawed Embryo Transfer

PHASE4CompletedINTERVENTIONAL
Enrollment

554

Participants

Timeline

Start Date

September 25, 2018

Primary Completion Date

November 1, 2024

Study Completion Date

November 1, 2024

Conditions
Embryo Transfer
Interventions
DRUG

Natural cycle

no medication

DRUG

Estradiol Valerate

Oestradiol valerate (Progynova, Bayer, Germany) 6mg daily will be given from day 2 of the cycle. The dose of Progynova is increased to 8mg daily if the endometrial thickness is less than 7mm after 7-10 days of Progynova use. Progynova will be discontinued the day of the pregnancy test in case of a negative result. In case of a pregnancy, Progynova will be continued until 12 weeks or until diagnosis of a non-viable pregnancy.

DRUG

Micronized progesterone

Micronized progesterone (Utrogestan, Besins, Belgium) 200 mg vaginally three times daily is started as soon as the endometrial thickness is 7 mm. Utrogestan will be discontinued the day of the pregnancy test in case of a negative result. In case of a pregnancy, Utrogestan will be continued until 12 weeks or until diagnosis of a non-viable pregnancy.

Trial Locations (1)

3000

UZ Leuven, Leuven

All Listed Sponsors
collaborator

GZA Ziekenhuizen Campus Sint-Augustinus

OTHER

collaborator

Imelda Hospital, Bonheiden

OTHER

collaborator

Jessa Hospital

OTHER

lead

Universitaire Ziekenhuizen KU Leuven

OTHER

NCT03642665 - Natural Versus Artificial Cycle for Frozen-Thawed Embryo Transfer | Biotech Hunter | Biotech Hunter