554
Participants
Start Date
September 25, 2018
Primary Completion Date
November 1, 2024
Study Completion Date
November 1, 2024
Natural cycle
no medication
Estradiol Valerate
Oestradiol valerate (Progynova, Bayer, Germany) 6mg daily will be given from day 2 of the cycle. The dose of Progynova is increased to 8mg daily if the endometrial thickness is less than 7mm after 7-10 days of Progynova use. Progynova will be discontinued the day of the pregnancy test in case of a negative result. In case of a pregnancy, Progynova will be continued until 12 weeks or until diagnosis of a non-viable pregnancy.
Micronized progesterone
Micronized progesterone (Utrogestan, Besins, Belgium) 200 mg vaginally three times daily is started as soon as the endometrial thickness is 7 mm. Utrogestan will be discontinued the day of the pregnancy test in case of a negative result. In case of a pregnancy, Utrogestan will be continued until 12 weeks or until diagnosis of a non-viable pregnancy.
UZ Leuven, Leuven
GZA Ziekenhuizen Campus Sint-Augustinus
OTHER
Imelda Hospital, Bonheiden
OTHER
Jessa Hospital
OTHER
Universitaire Ziekenhuizen KU Leuven
OTHER