Monitoring of Perfusion in Sepsis and Malaria

Use of lung ultrasound to detect pulmonary complications

CUS is a highly sensitive and specific modality used to recognize lower extremity deep venous thrombosis (DVT)

Echocardiogram can be (i) identify imminent life-threatening causes of hemodynamic failure, (ii) recognize coexisting diagnoses that complicate management, (iii) follow the evolution of the disease process, and (iv) monitor response to treatment

Measurement of the inferior vena cava diameter

Baseline assessment (including pulse rate, systolic and diastolic blood pressure, velocity time integral (VTI) and stroke volume (SV) echocardiographic measurements) will be performed in the resting semi-recumbent position, defined as a position with the trunk elevated 30° to 45° relative to the lower limbs.

Measurement of capillary flow in the rectal microcirculation

For urinalysis, biochemistry, urine microscopy, pH, and culture.

for: parasitological and microbiological diagnostics, complete blood count, biochemistry, red cell deformability analyzed by laser assisted rotational cell analyser (LORCA), markers of oxidative stress (peripheral intravenous catheter)

all patients will have an ECG performed on enrolment as a non-invasive investigation

GlycoCheck is a clinical sublingual handheld, bedside microscope that detects erythrocytes within the small sublingual blood vessels measuring 5 to 25 micrometers in diameter. The sublingual vasculature is a validated site for measuring thickness of the endothelial glycocalyx.