Endothelial Injury Mechanism in Elderly Patients Undergoing Major Surgery

PHASE4CompletedINTERVENTIONAL
Enrollment

464

Participants

Timeline

Start Date

July 1, 2019

Primary Completion Date

October 30, 2020

Study Completion Date

October 31, 2020

Conditions
Endothelial DysfunctionBlood Brain Barrier DefectPostoperative Cognitive Dysfunction
Interventions
DRUG

Dexmedetomidine

0.5μg/kg Dexmedetomidine as initial loading dose is given for 15 minutes before induction of anesthesia, followed by a maintenance infusion of 0.4μg/kg/h and stopped 30 minutes before the surgery over.

DRUG

Saline

0.5μg/kg saline as initial loading dose is given for 15 minutes before induction of anesthesia, followed by a maintenance infusion of 0.4μg/kg/h and stopped 30 minutes before the surgery over.

Trial Locations (2)

Unknown

The First Affiliated Hospital of Anhui Medical University, Hefei

Hangzhou cancer hospital, Hangzhou

All Listed Sponsors
collaborator

Hangzhou Cancer Hospital

OTHER

lead

The First Affiliated Hospital of Anhui Medical University

OTHER

NCT03639896 - Endothelial Injury Mechanism in Elderly Patients Undergoing Major Surgery | Biotech Hunter | Biotech Hunter