A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma

PHASE3CompletedINTERVENTIONAL
Enrollment

783

Participants

Timeline

Start Date

September 21, 2018

Primary Completion Date

November 19, 2021

Study Completion Date

March 19, 2024

Conditions
Melanoma
Interventions
BIOLOGICAL

NKTR-214

Specified dose on specified days

BIOLOGICAL

Nivolumab

Specified dose on specified days

Trial Locations (167)

0

Local Institution - 0174, Recoleta

Local Institution - 0136, Wilton

Local Institution - 0129, Dublin

4

Local Institution - 0128, Dublin

1000

Local Institution - 0083, Brussels

1011

Local Institution - 0105, Lausanne

1090

Local Institution - 0033, Vienna

1142

Local Institution - 0159, Auckland

1426

Local Institution - 0108, CABA

1430

Local Institution - 0109, Ciudad Autonoma de Buenos Aires

2060

Local Institution - 0053, North Sydney

2450

Local Institution - 0146, Coffs Harbour

3000

Local Institution - 0054, Melbourne

3004

Local Institution - 0143, Melbourne

3010

Local Institution - 0104, Bern

3500

Local Institution - 0084, Hasselt

4102

Local Institution - 0056, Woolloongabba

4120

Local Institution, Greenslopes

4870

Local Institution - 0058, Cairns

5000

Local Institution - 0157, Córdoba

5020

Local Institution - 0035, Salzburg

5112

Local Institution - 0172, Elizabeth Vale

6009

Local Institution - 0057, Nedlands

Local Institution - 0097, Nedlands

6021

Local Institution - 0062, Wellington

8011

Local Institution - 0063, Christchurch

8036

Local Institution - 0034, Graz

8091

Local Institution - 0036, Zurich

10060

Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia, Torino

10065

Local Institution - 0141, New York

10126

Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, Turin

11526

Local Institution - 0038, Athens

14004

Local Institution - 0123, Córdoba

15706

Local Institution - 0119, Santiago Compostela

18045

St. Luke's Hospital & Health Network, Easton

18547

Local Institution - 0039, Neo Faliro

19111

Local Institution - 0015, Philadelphia

20014

Local Institution - 0190, Doniostia - San Sebastian

Local Institution, Donostia / San Sebastian

20133

IRCCS Istituto Nazionale Tumori Milano, Milan

20141

Local Institution - 0045, Milan

20251

Local Institution - 0023, Hamburg

20520

Local Institution - 0165, Turku

21614

Local Institution - 0031, Buxtehude

22031

Local Institution - 0064, Fairfax

23007

Local Institution - 0118, Jaén

24105

Local Institution - 0028, Kiel

24127

ASST Papa Giovanni XXIII, Bergamo

28007

Local Institution - 0114, Madrid

31059

Local Institution - 0002, Toulouse

33075

Centre Hospitalier Universitaire de Bordeaux Hospital Saint Andre, Bordeaux

33136

Local Institution - 0153, Miami

33140

Local Institution - 0017, Miami Beach

33612

Local Institution - 0112, Tampa

34295

Hopital Saint Eloi, Montpellier

35128

Istituto Oncologico Veneto IOV, Padua

37075

Local Institution - 0030, Göttingen

40202

Local Institution - 0019, Louisville

42270

Local Institution - 0009, Saint-Priest-en-Jarez

44093

Local Institution - 0003, Nantes

44195

Local Institution - 0037, Cleveland

45070

Local Institution - 0176, Zapopan

45147

Local Institution - 0026, Essen

46014

Local Institution - 0117, Valencia

47014

Local Institution - 0113, Meldola (FC)

48109

Local Institution - 0188, Ann Arbor

48157

Local Institution - 0027, Münster

52621

Local Institution - 0089, Ramat Gan

53100

Local Institution - 0042, Siena

55432

Local Institution - 0186, Fridley

57001

Local Institution - 0040, Thessaloniki

59000

Hopital Claude Huriez, Lille

63110

Local Institution - 0135, St Louis

64460

Local Institution - 0177, Monterrey

64710

Local Institution - 0180, Monterrey

69120

Local Institution - 0020, Heidelberg

69310

Centre Hospitalier Lyon Sud, Pierre-Bénite

70029

Local Institution - 0167, KYS

70124

Local Institution - 0044, Bari

72076

Local Institution - 0025, Tübingen

72424

Local Institution - 0179, Puebla City

75475

Hopital Saint Louis, Paris

76000

CHU Charles Nicolle, Rouen

77030

Local Institution - 0001, Houston

77500

Local Institution - 0178, Cancún

78200

Local Institution - 0181, San Luis Potosí City

80045

Local Institution - 0051, Aurora

80131

Local Institution - 0043, Napoli

80337

Local Institution - 0021, München

84101

Local Institution - 0098, Beersheba

85724

Local Institution - 0187, Tucson

91120

Local Institution - 0088, Jerusalem

92093

Local Institution - 0014, La Jolla

93053

Local Institution - 0060, Regensburg

94305

Local Institution - 0122, Stanford

94805

Institute Gustave Roussy, Villejuif

97080

Local Institution - 0032, Würzburg

97213

Local Institution - 0011, Portland

97239

Local Institution - 0013, Portland

99089

Local Institution - 0192, Erfurt

105229

Local Institution - 0086, Moscow

115478

Local Institution - 0111, Moscow

121309

Local Institution - 0148, Moscow

200542

Local Institution - 0071, Craiova

400015

Local Institution - 0070, Cluj-Napoca

407280

Local Institution - 0120, Floreşti

660133

Local Institution - 0149, Krasnoyarsk

8330024

Local Institution - 0173, Santiago

06510

Local Institution - 0065, New Haven

30322-1013

Local Institution - 0012, Atlanta

02215

Local Institution - 0018, Boston

07601

Local Institution - 0016, Hackensack

08903

Local Institution - 0185, New Brunswick

C1118AAT

Local Institution - 0107, Buenos Aires

C1017

Local Institution - 0183, Buenos Aires

B-3000

Local Institution - 0085, Leuven

60130-241

Local Institution - 0168, Fortaleza

30130-090

Local Institution - 0125, Belo Horizonte

98700-000

Local Institution - 0124, Ijuí

90610-000

Local Institution - 0127, Porto Alegre

88301-220

Local Institution - 0171, Itajaí

14780-070

Local Institution - 0126, Barretos

20231-050

Local Institution - 0182, Rio de Janeiro

01509-010

Local Institution - 0169, São Paulo

V2S 0C2

Local Institution - 0068, Abbotsford

A1B 3V6

Local Institution - 0139, St. John's

L8V 5C2

Local Institution - 0066, Hamilton

N2G 1G3

Local Institution - 0067, Kitchener

M5G 2M9

Local Institution - 0041, Toronto

G1R 2J6

Local Institution, Québec

T6X 1E8

Local Institution - 0121, Edmonton

656 53

Local Institution - 0094, Brno

500 05

Local Institution - 0093, Hradec Králové

100 34

Local Institution - 0091, Prague

128 08

Local Institution - 0092, Prague

FI-33520

Local Institution - 0166, Tampere

06200

Local Institution - 0155, Nice

01307

Local Institution - 0029, Dresden

D30625

Local Institution - 0024, Hanover

04103

Local Institution - 0022, Leipzig

Dublin 7

Local Institution - 0130, Dublin

03100

Local Institution - 0175, Mexico City

1066CX

Local Institution - 0101, Amsterdam

1081 HV

Local Institution - 0102, Amsterdam

2333 ZA

Local Institution - 0099, Leiden

6525 GA

Local Institution - 0100, Nijmegen

3584CX

Local Institution - 0147, Untrecht

85-796

Local Institution - 0152, Bydgoszcz

02-781

Local Institution - 0090, Warsaw

1649-035

Local Institution - 0134, Lisbon

4200-072

Local Institution - 0133, Porto

022328

Local Institution - 0162, Bucharest

08035

Local Institution - 0116, Barcelona

08036

Local Institution - 0115, Barcelona

413 45

Local Institution - 0163, Gothenburg

222 42

Local Institution - 0164, Lund

SO16 6YD

Local Institution - 0132, Southampton

EH16 4SB

Local Institution, Edinburgh

SM25PT

Local Institution - 0131, Sutton

BT9 7AB

Local Institution - 0078, Belfast

CB2 0QQ

Local Institution - 0076, Cambridge

HU16 5JQ

Local Institution - 0079, Cottingham

L7 8YA

Local Institution - 0137, Liverpool

SW17 0RE

Local Institution - 0077, London

SW36JJ

Local Institution - 0074, London

M20 4BX

Local Institution - 0075, Manchester

TA1 5DA

Local Institution - 0142, Tauton

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Nektar Therapeutics

INDUSTRY

lead

Bristol-Myers Squibb

INDUSTRY