Efficacy and Safety Study of First-line Treatment With Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Women With Persistent, Recurrent, or Metastatic Cervical Cancer (MK-3475-826/KEYNOTE-826)

PHASE3CompletedINTERVENTIONAL
Enrollment

617

Participants

Timeline

Start Date

October 25, 2018

Primary Completion Date

October 3, 2022

Study Completion Date

June 4, 2024

Conditions
Cervical Cancer
Interventions
BIOLOGICAL

Pembrolizumab

IV infusion

DRUG

Paclitaxel

IV infusion

DRUG

Cisplatin

IV infusion

DRUG

Carboplatin

IV infusion

BIOLOGICAL

Bevacizumab

IV infusion

DRUG

Placebo to pembrolizumab

IV infusion

Trial Locations (149)

112

Koo Foundation Sun Yat-Sen Cancer Center ( Site 1636), Taipei

Taipei Veterans General Hospital ( Site 1631), Taipei

813

Kaohsiung Veterans General Hospital ( Site 1632), Kaohsiung City

2065

Royal North Shore Hospital ( Site 1514), St Leonards

3168

Monash Health-Monash Medical Centre ( Site 1519), Clayton

4101

Mater Misericordiae Ltd Mater Cancer Care Centre ( Site 1521), South Brisbane

5042

Flinders Medical Centre ( Site 1513), Bedford Park

6008

St John of God Subiaco Hospital ( Site 1512), Subiaco

10011

Mount Sinai Chelsea ( Site 1760), New York

10032

Columbia University Medical Center ( Site 1800), New York

13006

Hospital de Alta Complejidad de La Libertad Virgen de La Puerta ( Site 1152), Trujillo

13009

Institut Paoli Calmettes ( Site 1182), Marseille

14080

Instituto Nacional de Cancerologia. ( Site 1130), México

15033

Hospital Nacional Guillermo Almenara Irigoyen ( Site 1158), Lima

15036

Instituto de Oncologia y Radioterapia Clinica Ricardo Palma ( Site 1157), Lima

15038

Instituto Nacional de Enfermedades Neoplasicas ( Site 1153), Lima

15082

Hospital Nacional Arzobispo Loayza ( Site 1159), Lima

15801

Hospital Nacional Maria Auxiliadora ( Site 1155), Lima

20014

Onkologikoa - Instituto Oncologico de San Sebastian ( Site 1275), Doniostia - San Sebastian

20133

Istituto Nazionale Tumori ( Site 1251), Milan

20141

Istituto Europeo di Oncologia ( Site 1250), Milan

20251

Universitatsklinikum Hamburg-Eppendorf ( Site 1212), Hamburg

24105

Universitaetsklinikum Schleswig-Holstein Campus Kiel ( Site 1214), Kiel

26133

Klinikum Oldenburg AoeR ( Site 1218), Oldenburg

28033

MD Anderson Cancer Center Madrid ( Site 1273), Madrid

28223

Hospital Quiron Madrid ( Site 1277), Pozuelo de Alarcón

29425

MUSC Hollings Cancer Center ( Site 1819), Charleston

30177

Gynoncological Practice Lueck. Schrader. Noeding ( Site 1224), Hanover

30912

Georgia Cancer Center at Augusta University ( Site 1767), Augusta

31000

Centro Estatal de Cancerologia de Chihuahua ( Site 1123), Chihuahua City

33081

Centro di Riferimento Oncologico de Aviano Istituto Nazionale Tumori ( Site 1243), Aviano

33305

Chang Gung Medical Foundation. Linkou ( Site 1633), Taoyuan District

33612

H. Lee Moffitt Cancer Center and Research Institute ( Site 1754), Tampa

34722

Medeniyet University Goztepe Egitim ve Arastırma Hast. Merdivenkoy ( Site 1458), Istanbul

35040

Ege University Medical Faculty Tulay Aktas Oncology Hospital ( Site 1456), Izmir

35042

Centre Eugene Marquis ( Site 1187), Rennes

38138

West Cancer Center - East Campus ( Site 1763), Germantown

40138

A.O. Universitaria Policlinico S. Orsola-Malpighi ( Site 1245), Bolgna

40225

Universitaetsklinikum Duesseldorf ( Site 1220), Düsseldorf

40447

China Medical University Hospital ( Site 1635), Taichung

40705

Taichung Veterans General Hospital ( Site 1634), Taichung

41009

Hospital Universitario Virgen Macarena ( Site 1274), Seville

42080

Necmettin Erbakan Universitesi Meram Tip Fakultesi Hastanesi ( Site 1452), Konya

42601

Keimyung University Dongsan Medical Center ( Site 1603), Daegu

43026

OSU Wexner Medical Center ( Site 1817), Hilliard

45147

Universitatsklinikum Essen AoR ( Site 1213), Essen

48201

Barbara Ann Karmanos Cancer Institute ( Site 1785), Detroit

48202

Henry Ford Health System ( Site 1810), Detroit

49102

City Clinical Hosp.4 of DCC ( Site 1482), Dnipropetrovsk

61070

Communal non profit enterprise Regional Clinical Oncology Center ( Site 1489), Kharkiv

63011

Centre Jean Perrin ( Site 1181), Clermont-Ferrand

63110

Washington University School of Medicine ( Site 1779), St Louis

65055

MI Odessa Regional Oncological Centre ( Site 1493), Odesa

66269

Centro de Urologia Avanzada del Noreste S.A. de C.V. ( Site 1125), San Pedro Garza García

69104

Medical Centre LLC Oncolife ( Site 1485), Zaporizhzhya

73104

University of Oklahoma- Stephenson Oklahoma Cancer Center ( Site 1784), Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute, LLC ( Site 1768), Tulsa

75014

Groupe Hospitalier Broca Cochin Hotel Dieu ( Site 1183), Paris

76018

MI Precarpathian Clinical Oncology Center ( Site 1487), Ivano-Frankivsk

78240

Texas Oncology-San Antonio Medical Center ( Site 8001), San Antonio

80131

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1242), Napoli

80637

Rotkreuzklinikum Muenchen gGmbH. Studienzentrale Frauenklinik ( Site 1225), München

85016

Arizona Oncology Associates, PC- HAL ( Site 8005), Phoenix

91900

Faicic S de RL de CV ( Site 1133), Veracruz

92210

Institut Curie - Centre Rene Huguenin ( Site 1185), Saint-Cloud

92868

UC Irvine Health ( Site 1796), Orange

93053

Universitaet Regensburg ( Site 1221), Regensburg

97070

Medical Care and Research S.A. de C.V. ( Site 1135), Mérida

98109

Seattle Cancer Care Alliance ( Site 1777), Seattle

99508

Alaska Women's Cancer Care ( Site 1770), Anchorage

111511

Instituto Nacional de Cancerologia E.S.E ( Site 1095), Bogota

115478

FSBI National Medical Oncology Research Center n.a. N.N. Blokhina ( Site 1334), Moscow

125367

Medical Rehabilitation Center ( Site 1337), Moscow

197758

National Medical Research Center of Oncology n.a. N. N. Petrov ( Site 1348), Saint Petersburg

198255

Municipal Clinical Oncology Center ( Site 1346), Saint Petersburg

200001

Sociedad de Oncologia y Hematologia del Cesar Ltda. ( Site 1103), Valledupar

230002

Oncomedica S.A. ( Site 1098), Montería

420029

Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 1331), Kazan'

430005

National Research Ogarev Mordovia State University ( Site 1347), Saransk

450054

Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 1345), Ufa

520001

Instituto Cancerologico de Narino Ltda ( Site 1097), Pasto

630108

Novosibirsk Regional Clinical Oncology Dispensary ( Site 1358), Novosibirsk

634028

Tomsk Scientific Research Institute of Oncology ( Site 1360), Tomsk

760046

Hemato Oncologos S.A. ( Site 1100), Santiago de Cali

2520598

Oncocentro ( Site 1065), Viña del Mar

3525408

Rambam Medical Center ( Site 1364), Haifa

4810469

Instituto Clinico Oncologico del Sur ( Site 1062), Temuco

4941492

Rabin Medical Center ( Site 1365), Petah Tikva

5265601

Chaim Sheba Medical Center ( Site 1361), Ramat Gan

6423906

Sourasky Medical Center ( Site 1362), Tel Aviv

7500921

Fundacion Arturo Lopez Perez FALP ( Site 1061), Santiago

7510032

Sociedad Oncovida S.A. ( Site 1069), Santiago

8330024

Centro de Cancer Nuestra Senora de la Esperanza ( Site 1063), Santiago

8410101

Soroka Medical Center ( Site 1363), Beersheba

9103102

Shaare Zedek Medical Center ( Site 1366), Jerusalem

9112001

Hadassah Medical Center. Ein Kerem ( Site 1367), Jerusalem

06510

Smilow Cancer Hospital at Yale New Haven ( Site 1809), New Haven

07103

Cancer Institute of New Jersey at University Hospital ( Site 1762), Newark

07666

Holy Name Medical Center ( Site 1776), Teaneck

B1884BBF

Centro de Oncologia e Investigacion Buenos Aires COIBA ( Site 1006), Berazategui

C1118AAT

Hospital Aleman ( Site 1005), Buenos Aires

C1417DTB

Hospital de Oncologia Angel Roffo ( Site 1003), Buenos Aires

C1426ANZ

Instituto Medico Especializado Alexander Fleming ( Site 1009), Buenos Aires

F5300COE

Centro Oncologico Riojano Integral ( Site 1004), La Rioja

T4000IAK

Centro Medico San Roque ( Site 1001), San Miguel de Tucumán

T2N 4N2

Tom Baker Cancer Centre ( Site 1728), Calgary

V1Y 5L3

BC Cancer-Kelowna - Sindi Ahluwalia Hawkins Centre ( Site 1734), Kelowna

V5Z 4E6

BC Cancer - Vancouver Center ( Site 1722), Vancouver

R3E 0V9

CancerCare Manitoba ( Site 1725), Winnipeg

B3H 2Y9

Queen Elizabeth II Health Sciences Centre ( Site 1731), Halifax

L8V 5C2

Juravinski Cancer Centre ( Site 1735), Hamilton

N6A 5W9

London Regional Cancer Program - London HSC ( Site 1723), London

K1H 8L6

The Ottawa Hospital Cancer Centre ( Site 1736), Ottawa

M4N 3M5

Sunnybrook Research Institute ( Site 1733), Toronto

M5G 2M9

Princess Margaret Cancer Centre ( Site 1732), Toronto

G7H 5H6

CIUSSS du Saguenay-Lac-St-Jean ( Site 1729), Chicoutimi

H1T 2M4

CIUSSS de l Est de L Ile de Montreal - Hopital Maisonneuve-Rosemont ( Site 1726), Montreal

H2X 3E4

Centre Hospitalier de l Universite de Montreal - CHUM ( Site 1721), Montreal

G1R 2J6

CHU de Quebec-Universite Laval-Hotel Dieu de Quebec ( Site 1724), Québec

J1H 5N4

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 1730), Sherbrooke

080002

Biomelab S A S ( Site 1104), Barranquilla

01307

Universitaetsklinikum Carl Gustav Carus ( Site 1211), Dresden

00168

Policlinico Universitario -Agostino Gemelli ( Site 1241), Roma

277-8567

The Jikei University Kashiwa Hospital ( Site 1701), Kashiwa

277-8577

National Cancer Center Hospital East ( Site 1704), Kashiwa

791-0295

Ehime University Hospital ( Site 1693), Tōon

830-0011

Kurume University Hospital ( Site 1692), Kurume

003-0804

National Hospital Organization Hokkaido Cancer Center ( Site 1700), Sapporo

673-8558

Hyogo Cancer Center ( Site 1705), Akashi

028-3695

Iwate Medical University Hospital ( Site 1695), Shiwa-gun

903-0215

University of the Ryukyus Hospital ( Site 1706), Nakagami-gun

350-1298

Saitama Medical University International Medical Center ( Site 1691), Hidaka

411-8777

Shizuoka Cancer Center Hospital and Research Institute ( Site 1703), Sunto-gun

104-0045

National Cancer Center Hospital ( Site 1702), Tokyo

105-8471

The Jikei University Hospital ( Site 1697), Tokyo

135-8550

The Cancer Institute Hospital of JFCR ( Site 1698), Tokyo

160-8582

Keio University Hospital ( Site 1699), Tokyo

03100

Consultorio de Medicina Especializada del Sector Privado ( Site 1129), Mexico City

06100

CRYPTEX Investigacion Clinica S.A. de C.V. ( Site 1127), Mexico City

04001

Centro Medico Monte Carmelo ( Site 1156), Arequipa

03080

Seoul National University Hospital ( Site 1602), Seoul

05505

Asan Medical Center ( Site 1601), Seoul

06351

Samsung Medical Center ( Site 1604), Seoul

08916

Hospital Germans Trias i Pujol. ICO de Badalona ( Site 1276), Badalona

01250

Baskent Adana Dr Turgut Noyan Uygulama ve Arastirma Merkezi ( Site 1457), Adana

06230

Hacettepe University Medical Faculty ( Site 1459), Ankara

06490

Baskent Universitesi Ankara Hastanesi ( Site 1451), Ankara

07059

Akdeniz Universitesi Tip Fakultesi ( Site 1453), Antalya

03022

National Cancer Institute of the MoH of Ukraine ( Site 1484), Kyiv

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY

NCT03635567 - Efficacy and Safety Study of First-line Treatment With Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy in Women With Persistent, Recurrent, or Metastatic Cervical Cancer (MK-3475-826/KEYNOTE-826) | Biotech Hunter | Biotech Hunter