Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma

PHASE3CompletedINTERVENTIONAL
Enrollment

78

Participants

Timeline

Start Date

May 20, 2018

Primary Completion Date

June 16, 2022

Study Completion Date

December 31, 2023

Conditions
Recurrent Glioblastoma
Interventions
DIAGNOSTIC_TEST

ChemoID assay

"The ChemoID test is a CLIA-certified and CAP-accredited drug response assay performed by a hospital clinical pathology laboratory that uses a patient's live tumor cells to indicate which chemotherapy agent (or combinations) will kill not only bulk of tumor cells, but importantly the cancer stem cells (CSCs) that are known to cause cancer to recur. During the assay, cancer stem cells and bulk tumor cells from an individual patient are exposed to FDA-approved chemotherapy drugs.~The test measures the cytotoxic effect of actual doses of standard-of-care chemotherapies. The ChemoID drug response assay reports a prioritized list of effective and ineffective chemotherapies. The test is designed to target cancer stem cells to mitigate tumor relapse."

DRUG

Chemotherapy

Chemotherapies chosen by Physician or ChemoID assay are in the same list of FDA approved drugs to treat recurrent high-grade glioma

Trial Locations (13)

15212

Allegheny Health Network, Pittsburgh

17033

The Penn State Univeristy College of Medicine, Hershey

18015

St. Luke's University Health Network, Bethlehem

19104

Thomas Jefferson University Hospitals, Philadelphia

25326

Charleston Area Medical Center, Charleston

39216

University of Mississippi Medical Center, Jackson

43614

Toledo University, Toledo

45267

University of Cincinnati Cancer Institute, Cincinnati

70112

Louisiana State University Health Sciences Center, New Orleans

90027

Kaiser Permanente, Los Angeles

90033

Keck School of Medicine of the University of Southern California, Los Angeles

97225

Providence Cancer Center Oncology, Portland

04074

Maine Medical Center Research Institute, Scarborough

All Listed Sponsors
lead

Cordgenics, LLC

INDUSTRY

NCT03632135 - Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma | Biotech Hunter | Biotech Hunter