216
Participants
Start Date
October 19, 2018
Primary Completion Date
October 18, 2021
Study Completion Date
March 19, 2024
Pembrolizumab 200 mg
Pembrolizumab 200 mg intravenous (IV) infusion on Days 1 of each 3-week cycle for up to 17 cycles
Paclitaxel 45 mg/m^2
Paclitaxel 45 mg/m\^2 IV infusion on Days 1, 8, 15 of each 3-week cycle for Cycles 2, and 3 during radiation therapy.
Carboplatin AUC6
Carboplatin AUC6 IV infusion on Day 1 of the 21-day cycle for Cycle 1.
Cisplatin 75 mg/m^2
Cisplatin 75 mg/m\^2 IV infusion on Day 1 of each 21-day cycle for Cycles 1, 2, 3.
Pemetrexed 500 mg/m^2
Pemetrexed 500 mg/m\^2 IV infusion on Day 1 of each 21-day cycle for Cycles 1, 2, and 3.
Thoracic Radiation Therapy (TRT)
The target total dose of TRT will be 60 Gy in 30 daily fractions of 2 Gy, prescribed to the planning target volume.
Paclitaxel 200 mg/m^2
Paclitaxel 200 mg/m\^2 IV infusion on Day 1 of the 21-day cycle of Cycle 1.
Carboplatin AUC2
Carboplatin AUC2 IV infusion on Day 1, 8, 15 for Cycles 2 and 3 during radiation therapy.
Auckland City Hospital ( Site 0700), Auckland
Blacktown Hospital Western Sydney Local Health District ( Site 0204), Blacktown
MNCCI Port Macquarie Base Hospital ( Site 0200), Port Macquarie
Southern Medical Day Care Centre ( Site 0201), Wollongong
Ballarat Health Services ( Site 0206), Ballarat
National Cancer Center ( Site 1002), Goyang-si
Clinique Clairval ( Site 0311), Marseille
Charite Universitaetsmedizin Berlin - Campus-Virchow-Klinikum ( Site 0414), Berlin
Fox Chase Cancer Center ( Site 1433), Philadelphia
Katholisches Marienkrankenhaus gGmbH ( Site 0411), Hamburg
LungenClinic Grosshansdorf GmbH ( Site 0408), Großhansdorf
CHU Jean Minjoz ( Site 0301), Besançon
Clinica Universitaria de Navarra ( Site 1102), Madrid
Chungbuk National University Hospital ( Site 1003), Cheongju-si
Institut du Cancer de Montpellier ( Site 0300), Montpellier
C.H.R.U. de Rennes. Hopital de Pontchaillou ( Site 0302), Rennes
Hospital Universitario Virgen Macarena ( Site 1103), Seville
Ulsan University Hospital ( Site 1000), Ulsan
Augusta-Kranken-Anstalt Bochum ( Site 0401), Bochum
Parkview Cancer Institute ( Site 1415), Fort Wayne
Bethanien Krankenhaus Moers ( Site 0406), Moers
Henry Ford Hospital ( Site 1418), Detroit
ICO Centre Paul Papin ( Site 0309), Angers
Sanford Cancer Center Oncology Clinic ( Site 1434), Sioux Falls
North Shore University Health System ( Site 1413), Evanston
Centre Jean Perrin ( Site 0304), Clermont-Ferrand
Universitatsklinikum Mannheim GmbH ( Site 0413), Mannheim
St. Francis Cancer Treatment Center ( Site 1421), Grand Island
Thoraxklinik Heidelberg gGmbH am Universitaetsklinikum Heidelberg ( Site 0404), Heidelberg
CTCA Southwestern ( Site 1428), Tulsa
Clinique de L'Europe ( Site 0308), Amiens
Institut de Cancerologie Gustave Roussy ( Site 0305), Villejuif
St Joseph Heritage Healthcare ( Site 1403), Santa Rosa
Blokhin National Medical Oncology ( Site 0902), Moscow
National Medical Research Center of Oncology N.A. N.N. Petrov ( Site 0904), Saint Petersburg
Republican Clinical Oncology Dispensary of Tatarstan MoH ( Site 0910), Kazan'
Republican Clinical Oncology Dispensary of Republic of Bashkortostan ( Site 0903), Ufa
UMass Memorial Medical Center ( Site 1417), Worcester
Rutgers Cancer Institute of New Jersey ( Site 1422), New Brunswick
C.H. de Saint Quentin ( Site 0306), Saint-Quentin
Klinikum Chemnitz gGmbH ( Site 0410), Chemnitz
Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 0811), Bydgoszcz
Osrodek Badan Klinicznych przy Szpitalu Specjalistycznym ( Site 0802), Krakow
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 0800), Warsaw
Szpital Morski im. PCK. Szpitale Pomorskie Sp. Z o.o ( Site 0812), Gdynia
Szpital Wojewodzki w Koszalinie im. Mikolaja Kopernika ( Site 0813), Koszalin
Samsung Medical Center ( Site 1001), Seoul
Hospital Universitari Vall d Hebron ( Site 1101), Barcelona
Hospital Clinic de Barcelona ( Site 1100), Barcelona
Hospital Son Llatzer ( Site 1105), Palma de Mallorca
Southampton General Hospital ( Site 1204), Southampton
Royal Free NHS Foundation Trust ( Site 1200), London
Charing Cross Hospital ( Site 1208), London
Beacon Centre ( Site 1203), Taunton
Queen's Hospital ( Site 1201), Rom Valley
Leeds Teaching Hospitals NHS Trust ( Site 1209), Leeds
Merck Sharp & Dohme LLC
INDUSTRY