M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC)

PHASE3CompletedINTERVENTIONAL
Enrollment

304

Participants

Timeline

Start Date

October 1, 2018

Primary Completion Date

June 7, 2021

Study Completion Date

June 25, 2024

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

M7824

Participants received intravenous infusion of M7824 at a dose of 1200 milligrams (mg) once every 2 weeks until confirmed progression of disease, death, unacceptable toxicity, or study withdrawal.

DRUG

Pembrolizumab

Pembrolizumab: Participants received intravenous infusion of Pembrolizumab at a dose of 200 milligrams (mg) once every 3 weeks until confirmed progression of disease, death, unacceptable toxicity, or study withdrawal.

Trial Locations (119)

100

National Taiwan University Hospital, Taipei

1090

Universitair Ziekenhuis Brussel - Geriatrie, Brussels

3212

UZ Leuven, Pellenberg

3500

Jessa Ziekenhuis Hospital, Hasselt

4000

Centro Medico San Roque S.R.L., San Miguel de Tucumán

5530

CHU Mont-Godinne, Yvoir

5800

Instituto Medico Rio Cuarto, Río Cuarto

10967

Vivantes Klinikum Am Urban - Haematologie und Onkologie, Berlin

11217

Taipei Veterans General Hospital, Taipei

11490

Tri-Service General Hospital, Taipei

11525

251 General Air Force Hospital, Athens

11527

"General Hospital of Athens of Chest Disease SOTIRIA", Athens

13620

Seoul National University Bundang Hospital, Seongnam-si

13915

Hôpital Nord - AP-HM Marseille# - Service d'Oncologie Multidisciplinaire, Bouches-du-Rhône

14642

University of Rochester Medical Center, Rochester

15232

UPMC Cancer Center, Pittsburgh

20133

Fondazione IRCCS Istituto Nazionale dei Tumori - Medicina Oncologica I, Milan

21565

Gachon University Gil Medical Center, Incheon

22030

Trakya University Medical Faculty - Medical Oncology, Edirne

22031

Virginia Cancer Specialists, PC, Fairfax

22927

LungenClinic Grosshansdorf, Großhansdorf

23538

Universitaetsklinikum Schleswig- Holstein Campus Luebeck, Lübeck

28007

Hospital General Universitario Gregorio Marañon - Servicio de Oncologia Medica, Madrid

28041

Hospital Universitario 12 de Octubre - Servicio de Oncologia, Madrid

28644

Chungbuk National University Hospital, Cheongju-si

29010

Hospital Regional Universitario de Malaga, Málaga

30625

Medizinische Hochschule Hannover - Pneumologie, Hanover

31059

CHU de Toulouse - Hôpital Larrey - Service de Pneumologie et Oncologie Pneumologique, Toulouse

32256

Cancer Specialists, LLC - Department of Clinical Research, Jacksonville

32503

Woodlands Medical Specialists, Pensacola

33081

IRCCS Centro di Riferimento Oncologico - Oncologia Medica A, Aviano

33604

Groupe Hospitalier Sud - Hôpital Haut-Lévêque - Maison du Ha, Pessac

35033

CHU Rennes - Hopital Pontchaillou - service de pneumologie, Rennes

35805

Oncology Specialties, PC; Clearview Cancer Institute, Huntsville

37203

SCRI - Tennessee Oncology, Nashville

37232

Vanderbilt University Medical Center, Nashville

40138

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi - Oncologia Medica, Bologna

40202

Norton Cancer Institute, Louisville

40503

Baptist Health Lexington Oncology Associates, Lexington

40705

Taichung Veterans General Hospital, Taichung

41009

Hospital Universitario Virgen Macarena - Servicio de Oncologia, Seville

41013

Hospital Universitario Virgen del Rocio - Servicio de Oncologia, Seville

41380

Kocaeli University Research and Application Hospital, Kocaeli

43018

Medical and Preventive Treatment Institution Volyn Regional Oncological Dispensary - Dept of Oncochemotherapy, Lutsk

44195

Cleveland Clinic, Cleveland

44805

ICO - Site René Gauducheau, Saint-Herblain

46026

Hospital Universitari i Politecnic La Fe - Servicio de Oncologia Medica, Valencia

48202

Henry Ford Medical Center, Detroit

49102

CI Dnipropetrovsk CMCH #4 of Dnipropetrovsk RC Dept of Chemotherapy SI Dnipropetrovsk MA of MOHU - Ch of Oncology and MR, Dnipro

56429

General Hospital Papageorgiou-2nd Department of Dermatalogy, Thessaloniki

60637

The University of Chicago Medical Center, Chicago

61070

Communal Non-profit Enterprise Regional Center of Oncology - Parent, Kharkiv

62526

Decatur Memorial Hospital - Clinical Research, Decatur

64132

Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC - Menorah Medical Center - Oncology Account, Kansas City

68510

Southeast Nebraska Cancer Center, Lincoln

69059

"Medical center Oncolife", Zaporizhzhia

69373

Centre Léon Bérard, Lyon

71110

"University General Hospital of Heraklion PAGNI", Heraklion

76018

CI Transcarpathian Cl Onc Center Dep of Surgery#1 SHEI Ivano-Frankivsk NMU - Chair of Oncology, Ivano-Frankivsk

76022

Texas Oncology - Bedford, Bedford

77479

Texas Oncology, P.A. - Sugarland, Sugar Land

80131

Università degli studi della Campania Luigi Vanvitelli - Dipartimento di Oncologia, Napoli

80907

Rocky Mountain Cancer Centers - Colorado Springs, N. Nevada, Colorado Springs

82131

Asklepios Fachkliniken Muenchen-Gauting - Abteilung Internistische Onkologie, Gauting

83100

Azienda Ospedaliera San Giuseppe Moscati - U.O Oncologia Medica, Avellino

88000

CCCH City Oncological Center SHEI Uzhgorod NU - Ch of R&O of Faculty of PGE&PUT, Uzhhorod

88100

Azienda Ospedaliero Universitaria Mater Domini-Campus Universitario - Centro Oncologico, Catanzaro

90048

Cedars Sinai Medical Center - Inflammatory Bowel Disease Center (Clinic, Los Angeles

92120

Kaiser Permanente - Harbor City, San Diego

92868

UC Irvine Medical Center, Orange

93105

Sansum Clinic - Santa Barbara, Santa Barbara

94010

Centre Hospitalier Intercommunal de Créteil - Service de Pneumologie, Créteil

95123

Azienda Ospedaliera Univ. Policlinico Gaspare Rodolico - Unità Operativa di Oncologia, Catania

100142

Peking University Cancer Hospital, Beijing

200032

Shanghai Cancer Hospital, Fudan University, Shanghai

510080

Guangdong General Hospital, Guangzhou

6202 AZ

Maastricht University Medical Center - Dept of Medical Oncology, Maastricht

3015 CE

Erasmus Medisch Centrum, Rotterdam

5022 GC

St. Elisabeth Ziekenhuis - Parent, Tilburg

03080

Seoul National University Hospital, Seoul

03722

Severance Hospital, Yonsei University, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08003

Hospital del Mar - Servicio de Oncologia, Barcelona

08028

Hospital Universitari Quiron Dexeus - Servicio de Oncologia Medica, Barcelona

08035

Hospital Universitari Vall d'Hebron - Dept of Oncology, Barcelona

08908

ICO l´Hospitalet - Hospital Duran i Reynals - Servicio de Oncologia, L'Hospitalet de Llobregat

01370

Adana Numune Training and Research Hospital - Cardiology Department, Adana

06105

Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital - Oncology Department, Ankara

06360

Eastern Connecticut Hematology/Oncology Assoc., Norwich

07652

The Valley Hospital - Luckow Pavilion, Paramus

B1880BBF

Centro de Oncologia e Investigacion Buenos Aires, Berazategui

C1426ANZ

Instituto Medico Especializado Alexander Fleming, Ciudad Autonoma Buenos Aires

X5000JHQ

Sanatorio Allende, Córdoba

S2000KZE

Instituto de Oncología de Rosario, Rosario

14784-400

Hospital de Câncer de Barretos - Fundação Pio XII, Barretos

60336-045

CRIO - Centro Regional Integrado de Oncologia, Fortaleza

90610-000

Hospital São Lucas da PUCRS, Porto Alegre

20230-230

INCA - Instituto Nacional de Câncer, Rio de Janeiro

40170-110

NOB - Núcleo de Oncologia da Bahia, Salvador

09060-650

CEPHO - Centro de Estudos e Pesquisas em Hematologia e Oncologia - Faculdade de Medicina do ABC, Santo André

E2L 4L2

Saint John Regional Hospital, Saint John

T2N 4N2

Tom Baker Cancer Centre, Alberta

L3Y 2P9

Stronach Regional Cancer Centre - at Southlake, Ontario

Unknown

Universitaetsklinikum Regensburg - Klinik und Poliklinik fuer Innere Medizin II, Regensburg

The University of Hong Kong, Hong Kong

Saitama Medical University International Medical Center - Dept of Respiratory Medicine, Hidaka-shi

00000

Princess Margaret Hospital, Hong Kong

The Chinese University of Hong Kong - Emergency Medicine, Shatin

003-0804

NHO Hokkaido Cancer Center - Dept of Respiratory Medicine, Sapporo

104-0045

National Cancer Center Hospital - Dept of Respiratory Medicine, Chūōku

362-0806

Saitama Cancer Center, Kitaadachigun

135-8550

Cancer Institute Hospital of JFCR - Dept of Respiratory Medicine, Kōtoku

830-0011

Kurume University Hospital, Kurume-shi

541-8567

Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka

589-8511

Kindai University Hospital, Osakasayama-sh

1066 CX

Antoni van Leeuwenhoek Ziekenhuis, Amsterdam

1081 HV

VU Medisch Centrum, Amsterdam

9713 GZ

Universitair Medisch Centrum Groningen (UMCG) - Parent, Groningen

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

lead

EMD Serono Research & Development Institute, Inc.

INDUSTRY

NCT03631706 - M7824 Versus Pembrolizumab as a First-line (1L) Treatment in Participants With Programmed Death-ligand 1 (PD-L1) Expressing Advanced Non-small Cell Lung Cancer (NSCLC) | Biotech Hunter | Biotech Hunter