Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia

PHASE2CompletedINTERVENTIONAL
Enrollment

17

Participants

Timeline

Start Date

September 6, 2019

Primary Completion Date

September 21, 2021

Study Completion Date

February 14, 2024

Conditions
Waldenstrom Macroglobulinemia
Interventions
DRUG

Pembrolizumab

200 mg IV dose given on day 1 of a three week cycle

DRUG

Rituximab

375 mg/m2 IV dose given up to 8 times in the trial

Trial Locations (9)

PL6 8DH

Derriford Hospital, Univeristy Hospitals Plymouth NHS Trust, Plymouth

TQ2 7AA

Torbay and South Devon NHS Foundation Trust, Torquay

BH7 7DW

Royal Bournemouth Hospital, University Hospitals Dorset NHS Foundation Trust, Bournemouth

EC1A 7BE

St Bartholomew's Hospital, Barts Health NHS Trust, London

NW1 2PG

UCLH, Univeristy College London Hospitals NHS Foundation Trust, London

M20 4BX

The Christie Hospital, The Christie NHS Foundation Trust, Manchester

OX3 7LE

Churchill Hospital, Oxford Univeristy NHS Foundation Trust, Oxford

BS1 3NU

Bristol Haematology & Oncology Medical Centre, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol

NR4 7UY

Norfolk and Norwich University Hospital, Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

University College, London

OTHER

NCT03630042 - Investigating the Safety and Efficacy of Rituximab and Pembrolizumab in Relapsed/Refractory Waldenström's Macroglobulinaemia | Biotech Hunter | Biotech Hunter