Targeted Blood-pressure Management and Acute Kidney Injury After Coronary Artery Bypass Surgery

NARecruitingINTERVENTIONAL
Enrollment

612

Participants

Timeline

Start Date

August 14, 2018

Primary Completion Date

December 31, 2025

Study Completion Date

July 31, 2026

Conditions
Coronary Artery Bypass, Off-PumpIntraoperative HypotensionAcute Kidney InjuryPreventive MedicineIntraoperative Care
Interventions
DRUG

Targeted blood-pressure management

Prophylactic norepinephrine infusion is started before anesthetic induction and maintained throughout surgery. The target is to maintain systolic blood pressure at 110 mmHg or higher.

DRUG

Routine blood-pressure management

Phenylephrine (25-50 ug) is injected or vasopressors is infused only when necessary. The target is to maintain systolic blood pressure at 90 mmHg or higher during surgery.

Trial Locations (1)

100034

RECRUITING

Beijing University First Hospital, Beijing

All Listed Sponsors
lead

Peking University First Hospital

OTHER