129
Participants
Start Date
February 22, 2019
Primary Completion Date
January 9, 2025
Study Completion Date
January 9, 2025
Neuromuscular Electrical Stimulation (NMES)
The electrical stimulator will deliver a 2500 Hz alternating current, modulated at 75 bursts/s, with a ramp-up time of 2-seconds, followed by a 50-second rest period. Stimulus intensity set to generate a maximum voluntary isometric contraction (MVIC) of at least 40\& of the contralateral MVIC.
Eccentric Exercise (ECC)
4 sets of 10 repetitions of an eccentric leg press exercise performed at 70-90% of the 1 repetition maximum
Neuromuscular Electrical Stimulation (NMES) placebo
The electrical stimulator will deliver a 2500 Hz alternating current, modulated at 75 bursts/s, with a ramp-up time of 2-seconds, followed by a 50-second rest period. Stimulus intensity set to generate a maximum voluntary isometric contraction (MVIC) of 10-20% of the contralateral MVIC.
Eccentric Exercise (ECC) placebo
4 sets of 10 repetitions of an eccentric leg press exercise performed at 10-20% of the 1 repetition maximum
MedSport, Ann Arbor
University of Michigan, Ann Arbor
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
University of Connecticut
OTHER
University of Delaware
OTHER
University of North Carolina, Chapel Hill
OTHER
University of Michigan
OTHER