A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

1,000

Participants

Timeline

Start Date

August 30, 2018

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
PAHPulmonary HypertensionPulmonary Arterial HypertensionHypertensionConnective Tissue DiseasesFamilial Primary Pulmonary HypertensionVascular DiseasesCardiovascular DiseasesHypertension, PulmonaryLung DiseasesRespiratory Tract Disease
Interventions
DRUG

Ralinepag

Active

DRUG

Placebo

Placebo

Trial Locations (209)

704

National Cheng Kung University Hospital, Tainan City

1070

Cliniques Universitaires de Bruxelles Hopital Erasme, Brussels

1090

AKH Wien, Innere Med. II, Kardiologie, Währingergürtel 18-20, Vienna

1096

Gottsegen György Országos Kardiovaszkuláris Intézet, Budapest

1280

Hospital Britanico de Buenos Aires, Ciudad Autonoma Buenos Aires

1309

"MHAT - National Heart Hospital EAD, 65, Konyovitza Str.", Sofia

1425

Cardiologia Palmero, Caba

1426

Fundacion Respirar, Ciudad Autonoma Buenos Aires

1750

"MHAT Sveta Anna Sofia AD", Sofia

2000

Sanatorio Parque, Rosario

2010

St Vincent's Hospital Sydney, Darlinghurst

2050

Royal Prince Alfred Hospital, Camperdown

2100

Copenhagen University Hospital (Rigshospitalet), Copenhagen

2109

Macquarie University, Macquarie

2145

Westmead Hospital, Sydney

2751

Nepean Hospital, Kingswood

3000

"Hospital PROVINCIAL Dr. Jose Maria Cullen", Santa Fe

UZ Leuven, UZ Leuven Campus Gasthuisberg, Herestraat 49, Leuven

3004

The Alfred Hospital, Melbourne

3065

St Vincent's Hospital Melbourne, Fitzroy

4020

Ordensklinikum Linz GmbH - Elisabethinen, Fadingerstrasse 1, Linz

4032

The Prince Charles Hospital, Chermside

4102

Princess Alexandra Hospital, Woolloongabba

6020

Medizinische Universität Innsbruck, Innsbruck

6150

Fiona Stanley Hospital, Murdoch

7000

Royal Hobart Hospital, Hobart

7600

Instituto de Investigaciones Clinicas Mar del Plata, Mar del Plata

7624

Pecsi Tudomanyegyetem, Szivgyogyaszati Klinika, Ifjusag u. 13., Pécs

8200

Århus Universitetshospital, Aarhus

10000

Clinical Hospital Dubrava Zagreb, Avenija G.Šuška 6, Zagreb

University Clinic for Pulmonary Diseases, Jordanovac 104, Zagreb

10002

National Taiwan University Hospital, Taipei

10016

NYU Langone Medical Center, New York

10021

Weill-Cornell-New York Presbyterian Hospital, New York

10029

Mount Sinai School of Medicine, New York

11000

Clinical Center of Serbia, Koste Todorovica 8, Belgrade

11080

Clinical Center Zemun. Clinic for internal medicine, Department of Cardiology, Belgrade

11501

Winthrop Hospital, Mineola

12462

University General Hospital Attikon, Chaïdári

13015

Hôpital Nord - CHU Marseille, Marseille

14080

Instituto Nacional de Cardiologia Dr Ignacio Chavez Rivera, Mexico City

Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran, Mexico City

14642

University of Rochester, Rochester

15212

Allegheny General Hospital, Pittsburgh

16059

Uludag Universitesi Tip Fakültesi, Gorukle Kampusu, Bursa

16132

IRCC Ospedale Policlinico San Martino, Genova

17475

Universitätsmedizin Greifswald, Greifswald

17674

"Onasseio Cardiosurgery Hospital, Hemodynamic Research and Interventional Cardiology Dept., 356, Syggrou Avenue", Athens

19103

University of California, Irvine, Orange

19104

University of Pennsylvania, Philadelphia

19107

Thomas Jefferson University Hospital, Philadelphia

19140

Temple University, Philadelphia

20122

Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, Milan

20246

Universitaetsklinikum Hamburg-Eppendorf, Hamburg

20900

Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo), Monza

21201

University of Maryland Medical Center, Baltimore

21204

Institute for Pulmonary Diseases of Vojvodina, Put Dr Goldmana 4, Kamenitz

21565

Gachon University Hospital Gil Medical Center, Incheon

22908

University of Virginia Medical Center, Charlottesville

23507

Sentara Cardiovascular Research Institute, Norfolk

24014

Carilion Clinic Pulmonary and Sleep Medicine, Roanoke

25030

CHU Besançon - Hôpital Jean Minjoz, Besançon

26040

Osmangazi Uni Medical Faculty, Eskişehir

27100

Fondazione IRCCS Policlinico San Matteo, Pavia

27710

Duke University Medical Center, Durham

27834

East Carolina University, Greenville

28041

Hospital Universitario 12 de Octubre, Madrid

29609

CHU de Brest - Hôpital de la Cavale Blanche, Brest

30106

Piedmont Healthcare Pulmonary and Critical Care Research, Austell

30322

Emory University Hospital, Atlanta

32610

University of Florida, Gainesville

32803

Central Florida Pulmonary Group, Orlando

33136

University of Miami, Miami

33331

Cleveland Clinic Florida, Weston

33343

Mersin Üniversitesi Tip Fakültesi Ciftlikköy Kampüsü, Mersin

34899

Marmara Universitesi Istanbul Pendik Egitim ve Arastirma Hastanesi, Istanbul

35294

University of Alabama at Birmingham, Birmingham

35340

Dokuz Eylul Universitesi Tip Fakultesi, Mithatpasa caddesi Inciralti Balcova, Izmir

37919

Statcare Pulmonary Consultants, Knoxville

38048

CHU de Grenoble - Hôpital Albert Michallon, Clinique de Cardiologie, Boulevrad de la Chantourne, Grenoble

40202

Kentuckiana Pulmonary Research Center, Louisville

41345

Sahlgrenska Universitetssjukhuset, Gothenburg

42005

CHU de Saint-Etienne - Hopital Nord, Service de Medecine vasculaire et therapeutique, 81 Avenue A. Raimond, Saint-Étienne-de-Montluc

43210

The Ohio State University Wexner Medical Center, Columbus

44160

CICUM San Miguel, Guadalajara

44195

Cleveland Clinic, Cleveland

45267

University of Cincinnati-Medical Science Building, Cincinnati

46026

Hospoital Universitari i Politecnic La Fe, Valencia

46202

Indiana University School of Medicine, Indianapolis

46250

Community Health Network Cancer Center North, Indianapolis

46260

St. Vincent Medical Group, Inc., Indianapolis

49070

CE Dniprop RCC&C Center of Dniprop RC Dept of Card SI DMA of MOHU, Chair of Internal Medicine 3, 28, Knyazya Volodymyra Velykogo St., Dnipro

49546

Spectrum Health Medical Group, Grand Rapids

52242

University of Iowa Hospitals and Clinics, Iowa City

53226

Medical College of Wisconsin/Froedtert Hospital, Milwaukee

54511

CHU Nancy - Hôpital de Brabois Adultes, Pneumologie- Oncologie Médicale, Rue du Morvan, Vandœuvre-lès-Nancy

54636

AHEPA General Hospital of Thessaloniki, A' Cardiology Clinic, 1 St. Kyriakidi Street, Thessaloniki

55131

Universitaetsmedizin der Johannes-Gutenberg-Universitaet Mainz, Zentrum für Kardiologie I, Centrum für Thrombose und Hämostase (CTH), Langenbeckstrasse 1, Mainz

58185

Linköping Universitetssjukhuset, Linköping

59037

CHRU de Lille - Hopital Cardiologique, Lille

60007

Ascension Alexian Brothers, Elk Grove Village

60637

University of Chicago Medical Center, Chicago

63110

Washington University School of Medicine, St Louis

64718

Unidad de Investigacion Clinica en Medicina, S.C., Monterrey

66424

Universitaetsklinikum des Saarlandes, Innere Medizin V, IMED, Kirrberger Strasse 100, Gebäude 41, Homburg

67091

CHU de Strasbourg - Nouvel Hôpital Civil, Ctre de competence Hypertension Arterielle Pulmona, 1 place de l Hopital, Strasbourg

68100

University General Hospital of Alexandroupolis, Alexandroupoli

68198

Nebraska Medical Center, Omaha

69126

Thoraxklinik-Heidelberg Zentrum für Pulmonale Hypertonie, Heidelberg

69677

CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel, Service de Pneumologie, 59 Boulevard Pinel, Bron

70121

Ochsner Medical Center, New Orleans

71100

Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, S.C. di Cardiologia, Viale Luigi Pinto, 1, Foggia

73112

Integris Baptist Medical Center, Oklahoma City

75246

Baylor University Medical Center, Dallas

75390

UT Southwestern Medical Center, Dallas

76031

CHU de Rouen - Hôpital Charles Nicolle, Rouen

77030

Memorial Hermann Hospital, Houston

The Methodist Hospital Research Institute, Houston

78166

Schwarzwald-Baar Klinikum, Donaueschingen

78705

Ascension Texas Cardiovascular, Austin

79010

Communal Noncommercial Enterprise of Lviv Regional Council Lviv Clinical Hospital, Dept of Cardiology, D.Halytskyi Lviv NMU, Ch of Internal Medicine #1, 7, Chernihivska str., Lviv

80045

University of Colorado Hospital, Aurora

80206

National Jewish Health, Denver

85013

St. Joseph's Hospital and Medical Center, Phoenix

85724

University of Arizona, Tucson

87131

University of New Mexico, Albuquerque

90024

Ronald Reagan UCLA Medical Center, Los Angeles

90027

Kaiser Permanente Los Angeles Medical Center, Los Angeles

90033

Keck Hospital of USC, Los Angeles

90048

Cedars-Sinai Medical Center, Los Angeles

90073

VA Greater Los Angeles Healthcare System, Los Angeles

90127

Istituto Mediterraneo Trapianti e Terapie a Alta Specializzazione (IRCCS-ISMETT), Palermo

90185

Norrlands Universitetssjukhus, Hjärtcentrum, Umeå

90502

LA Biomedical Research Institute Harbor-UCLA Medical Center, Torrance

92037

UCSD Health Sciences, La Jolla

92354

Loma Linda University Medical Center, Loma Linda

93105

SBPA Research LLC, Santa Barbara

94275

Groupement Hospitalier Sud - Hôpital Bicêtre, Le Kremlin-Bicêtre

94305

Stanford Healthcare, Stanford

95817

University of California Davis Medical Center, Sacramento

97225

Oregon Clinic-Pulmonary West, Portland

97239

Oregon Health & Science University, Portland

100037

Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing

100038

Beijing Shijitan Hospital, Capital Medical University, Beijing

119074

National University Hospital, Singapore

169609

National Heart Centre, Singapore

200443

Shanghai Pulmonary Hospital, Shanghai

300310

"Spitalul Clinic de Boli Infectioase si Pneumoftiziologie Dr. Victor Babes Timisoara, Str. Gheorghe Adam nr. 13", Timișoara

400001

"Institutul Inimii Niculae Stancioiu Cluj-Napoca, Cardiologie, Str. Motilor nr. 19-21", Cluj-Napoca

410008

Xiangya Hospital Central South University, Changsha

510080

Guangdong Provincial People's Hospital, Guangzhou

3436212

The Lady Davis Carmel Medical Center, 7 Michal st., Haifa

4428164

Meir Medical Center, 59 Tshernichovski st., Kfar Saba

4941492

Rabin Medical Center-Beilinson Campus, Pulmonary Institute, 39 Jabotinsky St Ground floor, Petah Tikva

6423906

Tel Aviv Sourasky Medical Center, 6 Weizmann St., Tel Aviv

7500691

Instiuto Nacional del Torax, Providencia

9112001

Hadassah Ein Kerem Medical Center, Kiryat Hadassah, Jerusalem

04106

Chest Medicine Associates, South Portland

02111

Tufts Medical Center, Boston

02114

Massachusetts General Hospital, Boston

02118

Boston University Medical Center, Boston

05446

Vermont Lung Center, Colchester

C1039AAO

Sanatorio de la Trinidad Mitre, Buenos Aires

C1181ACH

Hospital Italiano, Ciudad Autonoma Buenos Aires

C1093AAS

Fundacion Favaloro, Ciudad Autonoma Buenos Aires

Unknown

Instituto de Cardiologia de Corrientes, Corrientes

X5016KEH

Hospital Privado Centro Medico de Cordoba S.A, Córdoba

X5004BAL

Hospital Italiano de Cordoba, Córdoba

74605-020

HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás, Goiânia

30441-070

Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa, Belo Horizonte

90610-000

Hospital Sao Lucas da PUC-RS, Porto Alegre

90035-074

Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre

18618-687

UNESP-Faculdade de Medicina da Universidade Estadual Paulista Campus Botucatu, Botucatu

04037-002

Hospital Sao Paulo, São Paulo

05403-000

Instituto do Coracao, São Paulo

T1Y 6J4

Peter Lougheed Centre, Calgary

N6A 5W9

LHSC - Victoria Hospital, London

M5G 2N2

University Health Network-Toronto General Hospital, Toronto

H3T1E2

SMBD Jewish General Hospital d/b/a Jewish General Hospital, Montreal

G1V 4G5

Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Québec

128 08

Vseobecna fakultni nemocnice v Praze, II. interni klinika kardiologie a angiologie VFN a 1. LF UK, U nemocnice 2, Prague

04103

Universitätsklinikum Leipzig, Medizinische Klinik II, Pneumologie, Leipzig

01307

Universitaetsklinikum Carl Gustav Carus TU Dresden, Dresden

Hungary

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ Családorvosi Intézet és Rendelő, Szeged

00161

Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Viale del Policlinico, 155, Roma

1081 HV

VU Medisch Centrum, De Boelelaan 1117, Amsterdam

15-276

Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Kardiologii z Oddzialem Intensywnego Nazdoru Kardiologicznego, M. Sklodowskiej 24a, Bialystok

31-202

Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddział Kliniczny Chorób Serca i Naczyń z Pododdziałem Intensywnego Nadzoru Kardiologicznego, Pradnicka 80, Krakow

05-400

NZOZ Europejskie Centrum Zdrowia, ul. Borowa 14/18, Otwock

61-848

Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Oddzial Kardiologii - F, ul. Dluga 1/2, Poznan

50-414

Premium Clinic Wrocław CM, Podwale 83/17, Wroclaw

4099-001

Centro Hospitalar de Santo António E.P.E., Porto

2805-267

Hospital Garcia de Orta, E.P.E, Almada

3000-075

Centro Hospitalar e Universitário de Coimbra, E.P.E., Coimbra

1769-001

Centro Hospitalar Universitário Lisboa Norte, E.P.E. Hospital Pulido Valente, Lisbon

022328

"Institutul de Urgenta pentru Boli Cardiovasculare Prof. Dr. C.C. Iliescu, Sos. Fundeni nr. 258", Bucharest

050159

"Institutul de Pneumoftiziologie Marius Nasta, Sos. Viilor nr. 90, Sector 5", Bucharest

06351

Samsung Medical Center, Seoul

03080

Seoul National University Hospital, Seoul

08035

Hospital Universitari Vall d'Hebron, Respiratory Dept., Passeig Vall d'Hebron,119-129, Neumologia, Barcelona

08036

Hospital Clinic de Barcelona, C/ Villarroel, 170, Barcelona

01330

Balcalı, Çukurova Üniversitesi Kardiyoloji ABD, Adana

06560

Gazi University Medical Faculty Hospital, Ankara

03680

SI F.H.Yanovskyi National Institute of Phthisiology and Pulmonology of NAMSU, Clinical and Functional Dept, 10, Amosova St., Kyiv

NW3 2QG

Royal Free London NHS Foundation Trust, Pond Street, London

NE7 7DN

The Newcastle upon Tyne Hospitals NHS Foundation Trust, Sir William Leech Lung Research Centre, Newcastle upon Tyne

G81 4DY

Golden Jubilee National Hospital, Glasgow

SW3 6NP

Royal Brompton Hospital, London

W12 0HS

Imperial College Healthcare NHS Trust, London

Sponsors
All Listed Sponsors
lead

United Therapeutics

INDUSTRY