56
Participants
Start Date
October 22, 2018
Primary Completion Date
August 1, 2029
Study Completion Date
August 1, 2030
Busulfan
Randomization between low and medium doses of busulfan for TCR αβ+/CD19+ depleted haploidentical related and unrelated donor HCT.
Cell processing for TCRαβ+/CD19+ depletion
T-cells and B-cells will be removed from the stem cells collected from the donor by an investigational process called alpha-beta CD3+/CD19+ t-cell depletion using a device called CliniMACS® prior to recipient infusion, hopefully minimizing the risk of significant graft vs. host disease (GVHD) or lymphoproliferative disorder.
RECRUITING
Morgan Stanley Children's Hospital of New York-Presbyterian - Columbia University Medical Center, New York
RECRUITING
Memorial Sloan Kettering Cancer Center - Peds, New York
RECRUITING
Westchester Medical Center, Valhalla
RECRUITING
Cohen Children's Medical Center, Queens
RECRUITING
Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RECRUITING
Children's Hospital of Philadelphia, Philadelphia
RECRUITING
Nemours Alfred I. duPont Hospital for Children, Wilmington
RECRUITING
Children's National Medical Center, Washington D.C.
RECRUITING
Virginia Commonwealth University Massey Cancer Center, Richmond
RECRUITING
Duke University Medical Center; Pediatric Blood and Marrow Transplant, Durham
RECRUITING
Levine Children's Hospital, Charlotte
WITHDRAWN
Medical University of South Carolina, Charleston
RECRUITING
Children's Healthcare of Atlanta at Egleston, Atlanta
RECRUITING
Shands HealthCare & University of Florida, Gainesville
RECRUITING
University of Miami/Jackson Memorial Hospital, Miami
RECRUITING
All Children's Hospital, St. Petersburg
RECRUITING
Univeristy of Alabama at Birmingham, Birmingham
RECRUITING
Vanderbilt University Medical Center, Nashville
RECRUITING
Nationwide Children's Hospital, Columbus
RECRUITING
Cleveland Clinic Foundation, Cleveland
RECRUITING
Cincinnati Children's Hospital Medical Center, Cincinnati
RECRUITING
Indiana University Hospital/Riley Hospital for Children, Indianapolis
RECRUITING
The University of Michigan, Ann Arbor
RECRUITING
Helen DeVos Children's, Grand Rapids
RECRUITING
University of Iowa Hospitals & Clinics, Iowa City
RECRUITING
Children's Hospital of Wisconsin, Milwaukee
RECRUITING
University of Wisconsin Hospital and Clinics, Madison
RECRUITING
University of Minnesota Blood and Marrow Transplant Program - Pediatrics, Minneapolis
RECRUITING
Comer Children's Hospital/University of Chicago Medicine, Chicago
RECRUITING
Cardinal Glennon Children's Medical Center, St Louis
RECRUITING
Washington University/St. Louis Children's Hospital, St Louis
RECRUITING
The Children's Mercy Hospitals and Clinics, Kansas City
RECRUITING
Nebraska Medicine, Omaha
RECRUITING
Children's Hospital / LSUHSC, New Orleans
RECRUITING
Children's Medical Center Dallas, Dallas
RECRUITING
M.D. Anderson Cancer Center, Houston
WITHDRAWN
Methodist Children's Hospital, San Antonio
RECRUITING
University of Colorado - Children's Hospital, Aurora
RECRUITING
Utah Blood and Marrow Transplant Program-Peds, Salt Lake City
RECRUITING
Mayo Clinic Arizona and Phoenix Children's Hospital, Phoenix
RECRUITING
Children's Hospital Los Angeles, Los Angeles
RECRUITING
UCLA Center for Health Sciences, Los Angeles
RECRUITING
Rady Children's Hospital, San Diego, San Diego
RECRUITING
University of California San Francisco Medical Center - Peds, San Francisco
WITHDRAWN
Lucile Packard Children's Hospital / Stanford Children's Health, Stanford
RECRUITING
Fred Hutchinson Cancer Research Center, Seattle
RECRUITING
Dana Farber Cancer Institute - Peds, Boston
RECRUITING
Hackensack University Medical Center, Hackensack
RECRUITING
Oregon Health and Science University, Portland
RECRUITING
Centre Hospitalier Universitaire Sainte-Justine, Montreal
RECRUITING
TheHospital fo Sick Children, Toronto
RECRUITING
Cancer Care Manitoba/University of Manitoba, Winnipeg
Center for International Blood and Marrow Transplant Research
NETWORK