549
Participants
Start Date
October 2, 2018
Primary Completion Date
January 20, 2025
Study Completion Date
January 20, 2025
Atezolizumab
Atezolizumab will be administered as I.V. infusion at a fixed dose of 1200 mg, every 21 days until objective radiological disease progression as assessed by the investigator if they do not meet any other discontinuation criteria (patient refusal, toxicity).
Placebos
Placebo will be administered as I.V. infusion every 21 days until objective radiological disease progression as assessed by the investigator if they do not meet any other discontinuation criteria (patient refusal, toxicity).
Paclitaxel
Paclitaxel 175 mg/m2 will be administered every 21 days for 6-8 cycles or until progression of disease.
Carboplatin
Carboplatin AUC 5 or AUC 6 will be administered every 21 days for 6-8 cycles or until progression of disease.
Royal Adelaide hospital, Adelaide
Border Medical Oncology Research Unit, Albury
Icon Cancer Centre, Auchenflower
Pindara Private Hospital, Benowa
Box Hill Hospital, Box Hill
Frankston Hospital, Frankston
Gosford Hospital, Gosford
Royal Brisbane and Women's Hospital, Herston
Royal Hobart Hospital, Hobart
Liverpool Hospital, Liverpool
Northern Cancer Institute, Saint Leonards
Darling Downs Hospital and Health Service - Toowoomba Hospital, Toowoomba
Calvary Mater Newcastle, Waratah
Wollongong Hospital, Wollongong
Medizinische Universitaet Graz - Universitätsklinik für Frauenheilkunde und Geburtshilfe, Graz
Medical University of Innsbruck, Innsbruck
Charité Universitätsmedizin Berlin, Berlin
Kliniken Essen Mitte, Essen
UniversitätsKlinikum Heidelberg, Mannheim
Klinikum der Ludwig-Maximilians-Universität München (LMU), München
AO SS Antonio e Biagio e Cesare Arrigo, Alessandria
Policlinico S. Orsola Malpighi, Bologna
Azienda Sanitaria dell'Alto Adige, Bolzano
ASST degli Spedali Civili di Brescia, Brescia
Fondazione Poliambulanza, Brescia
AOU Cagliari, Policlinico Universitario, Cagliari
AOU Careggi, Florence
ASST di Lecco, Lecco
Ospedale San Luca, Lucca
Istituto Europeo di Oncologia, Milan
Ospedale San Gerardo, Monza
Istituto Oncologico Veneto (IOV), Padua
AOU di Parma, Parma
AOU Pisana, Pisa
AO Arcispedale Santa Maria Nuova, Reggio Emilia
Ausl Romagna, Rimini
"Policlinico Umberto I, Università di Roma La Sapienza", Roma
Ospedale di Sondrio ASST Valtellina e Alto Lario, Sondrio
Ospedale SS Trinità, Sora
AO Ordine Mauriziano, Torino
AOU Città della Salute e della Scienza di Torino - Ospedale Sant'Anna, Torino
P.O Sant'Andrea Vercelli, Vercelli
Hirosaki University Hospital, Aomori
National Cancer Center Hospital East, Chiba
Shikoku Cancer Center, Ehime
Kurume University Hospital, Fukuoka
Hokkaido University Hospital, Hokkaido
Tohoku University Hospital, Miyagi
Niigata University Medical＆Dental Hospital, Niigata
Osaka University Hospital, Osaka
Shizuoka Cancer Center, Shizuoka
Keio University Hospital, Tokyo
Auckland city Hospital, Auckland
Keimyung University Dongsan Medical Center, Daegu
Ilsan Cha Medical Center, Gyeonggi-do
Seoul National University Bundang Hospital, Gyeonggi-do
Gachon University Gil Medical Center, Incheon
Asan Medical Center, Seoul
Gangnam Severance Hospital, Seoul
Konkuk University Medical Center, Seoul
Samsung Medical Center, Seoul
Seoul St. Mary's Hospital, Seoul
Severance Hospital, Seoul
Hospital De Sant Pau I La Santa Creu, Barcelona
Hospital Universitario Vall d´Hebron Institute of Oncology (VHIO), Barcelona
Institut Català d'Oncologia (ICO) Girona, Girona
Institut Català d'Oncologia (ICO), L'Hospitalet- Hospital Duran I Reynals, L'Hospitalet de Llobregat
Hospital 12 de Octubre, Madrid
Hospital Universitario La Paz, Madrid
MD Anderson Cancer Center, Madrid
Hospital Universitario Central de Asturias, Oviedo
Hospital Clínico Universitario Santiago de Compostela, Santiago de Compostela
Hospital Universitario Miguel Servet Zaragoza, Zaragoza
Kantonsspital, Baden
Universitätsspital, Basel
IOSI, Bellinzona
Inselspital, Bern
Kantonsspital, Lucerne
Frauenfeld, Münsterlingen
Kantonsspital, Winterthur
Universitätsspital, Zurich
Chang Gung Memorial Hospital-Kaohsiung, Kaohsiung City
Chang Gung Memorial Hospital-Linkou, Taoyuan
Royal Derby Hospital, Derby
Royal Devon & Exeter Hospital, Exeter
Beatson West of Scotland Cancer Centre, Gartnavel General Hospital, Glasgow
Velindre Cancer Centre, Glasgow
Imperial College Healthcare NHS Trust, London
Royal Marsden Hospital, London
St Bartholomew's Hospital, London
The Christie NHS Foundation Trust, Manchester
NUHT - Nottingham University Hospital NHS Trust, Nottingham
Derriford Hospital, Plymouth
Hoffmann-La Roche
INDUSTRY
Mario Negri Institute for Pharmacological Research
OTHER