Testing Whether the Combination of Two Immunotherapy Drugs Have Activity in Recurrent or Persistent Clear Cell Ovarian Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

14

Participants

Timeline

Start Date

December 21, 2018

Primary Completion Date

February 1, 2021

Study Completion Date

March 27, 2024

Conditions
Malignant Ovarian Clear Cell TumorRecurrent Ovarian Carcinoma
Interventions
DRUG

Epacadostat

Given PO

BIOLOGICAL

Pembrolizumab

Given IV

Trial Locations (363)

10601

Dickstein Cancer Treatment Center, White Plains

19090

Asplundh Cancer Pavilion, Willow Grove

21287

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

University of Virginia Cancer Center, Charlottesville

30912

Augusta University Medical Center, Augusta

32504

Sacred Heart Hospital, Pensacola

33146

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

37343

Pulmonary Medicine Center of Chattanooga-Hixson, Hixson

37363

Memorial GYN Plus, Ooltewah

37404

Memorial Hospital, Chattanooga

40004

Flaget Memorial Hospital, Bardstown

40165

Jewish Hospital Medical Center South, Shepherdsville

40202

Jewish Hospital, Louisville

40215

Saints Mary and Elizabeth Hospital, Louisville

40245

UofL Health Medical Center Northeast, Louisville

40504

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

43015

Delaware Health Center-Grady Cancer Center, Delaware

Delaware Radiation Oncology, Delaware

Grady Memorial Hospital, Delaware

43050

Knox Community Hospital, Mount Vernon

43055

Licking Memorial Hospital, Newark

Newark Radiation Oncology, Newark

43081

Saint Ann's Hospital, Westerville

43130

Fairfield Medical Center, Lancaster

43210

Ohio State University Comprehensive Cancer Center, Columbus

43213

Mount Carmel East Hospital, Columbus

43214

Columbus Oncology and Hematology Associates Inc, Columbus

Riverside Methodist Hospital, Columbus

43215

Grant Medical Center, Columbus

43219

The Mark H Zangmeister Center, Columbus

43222

Mount Carmel Health Center West, Columbus

43228

Doctors Hospital, Columbus

43302

OhioHealth Marion General Hospital, Marion

43560

ProMedica Flower Hospital, Sylvania

43606

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

43701

Genesis Healthcare System Cancer Care Center, Zanesville

44024

Geauga Hospital, Chardon

44060

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor

44106

Case Western Reserve University, Cleveland

44109

MetroHealth Medical Center, Cleveland

44111

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland

44122

UHHS-Chagrin Highlands Medical Center, Beachwood

44124

Hillcrest Hospital Cancer Center, Mayfield Heights

44145

UHHS-Westlake Medical Center, Westlake

44195

Cleveland Clinic Foundation, Cleveland

44266

University Hospitals Portage Medical Center, Ravenna

44281

University Hospitals Sharon Health Center, Wadsworth

44903

OhioHealth Mansfield Hospital, Mansfield

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

45601

Adena Regional Medical Center, Chillicothe

45662

Southern Ohio Medical Center, Portsmouth

45714

Strecker Cancer Center-Belpre, Belpre

45750

Marietta Memorial Hospital, Marietta

46260

Ascension Saint Vincent Indianapolis Hospital, Indianapolis

48060

Huron Medical Center PC, Port Huron

Lake Huron Medical Center, Port Huron

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Mission Cancer and Blood - Des Moines, Des Moines

50314

Broadlawns Medical Center, Des Moines

Mercy Medical Center - Des Moines, Des Moines

Mission Cancer and Blood - Laurel, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

Mission Cancer and Blood - West Des Moines, Clive

50501

Trinity Regional Medical Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

51503

Alegent Health Mercy Hospital, Council Bluffs

52242

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53022

Aurora Health Care Germantown Health Center, Germantown

53024

Aurora Cancer Care-Grafton, Grafton

53066

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

Aurora Medical Center in Summit, Summit

53081

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53142

Aurora Cancer Care-Kenosha South, Kenosha

53149

ProHealth D N Greenwald Center, Mukwonago

53188

ProHealth Waukesha Memorial Hospital, Waukesha

UW Cancer Center at ProHealth Care, Waukesha

53209

Aurora Cancer Care-Milwaukee, Milwaukee

53215

Aurora Saint Luke's Medical Center, Milwaukee

53226

Medical College of Wisconsin, Milwaukee

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

Aurora West Allis Medical Center, West Allis

53233

Aurora Sinai Medical Center, Milwaukee

53406

Aurora Cancer Care-Racine, Racine

54017

Cancer Center of Western Wisconsin, New Richmond

54143

Aurora Bay Area Medical Group-Marinette, Marinette

54241

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

Aurora BayCare Medical Center, Green Bay

54904

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55082

Lakeview Hospital, Stillwater

55092

Fairview Lakes Medical Center, Wyoming

55101

Regions Hospital, Saint Paul

55102

United Hospital, Saint Paul

55109

Minnesota Oncology Hematology PA-Maplewood, Maplewood

Saint John's Hospital - Healtheast, Maplewood

55125

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

Fairview Ridges Hospital, Burnsville

55362

Monticello Cancer Center, Monticello

55369

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55379

Saint Francis Regional Medical Center, Shakopee

55387

Ridgeview Medical Center, Waconia

55407

Abbott-Northwestern Hospital, Minneapolis

55415

Hennepin County Medical Center, Minneapolis

55416

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55432

Unity Hospital, Fridley

55433

Mercy Hospital, Coon Rapids

55435

Fairview Southdale Hospital, Edina

55454

Health Partners Inc, Minneapolis

55905

Mayo Clinic in Rochester, Rochester

56073

New Ulm Medical Center, New Ulm

56201

Rice Memorial Hospital, Willmar

57105

Avera Cancer Institute, Sioux Falls

59101

Billings Clinic Cancer Center, Billings

Saint Vincent Healthcare, Billings

59102

Saint Vincent Frontier Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59701

Saint James Community Hospital and Cancer Treatment Center, Butte

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59802

Saint Patrick Hospital - Community Hospital, Missoula

59804

Community Medical Center, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60451

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

University of Chicago Medicine-Orland Park, Orland Park

60504

Rush - Copley Medical Center, Aurora

60521

Sudarshan K Sharma MD Limited-Gynecologic Oncology, Hinsdale

60560

Rush-Copley Healthcare Center, Yorkville

60637

University of Chicago Comprehensive Cancer Center, Chicago

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

62864

Good Samaritan Regional Health Center, Mount Vernon

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63128

Mercy Hospital South, St Louis

63141

Mercy Hospital Saint Louis, St Louis

64108

University Health Truman Medical Center, Kansas City

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66061

Olathe Health Cancer Center, Olathe

66205

University of Kansas Hospital-Westwood Cancer Center, Westwood

66606

University of Kansas Health System Saint Francis Campus, Topeka

66762

Ascension Via Christi - Pittsburg, Pittsburg

67337

Coffeyville Regional Medical Center, Coffeyville

67401

Salina Regional Health Center, Salina

67601

HaysMed, Hays

68046

Midlands Community Hospital, Papillion

68114

Nebraska Methodist Hospital, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

Hematology and Oncology Consultants PC, Omaha

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island

68845

Heartland Hematology and Oncology, Kearney

68847

CHI Health Good Samaritan, Kearney

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

72205

University of Arkansas for Medical Sciences, Little Rock

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

77030

M D Anderson Cancer Center, Houston

77802

Saint Joseph Regional Cancer Center, Bryan

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

The Medical Center of Aurora, Aurora

80026

Good Samaritan Medical Center, Lafayette

80033

SCL Health Lutheran Medical Center, Wheat Ridge

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Swedish Medical Center, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80122

Littleton Adventist Hospital, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

Sky Ridge Medical Center, Lone Tree

80138

Parker Adventist Hospital, Parker

Rocky Mountain Cancer Centers-Parker, Parker

80206

National Jewish Health-Main Campus, Denver

80209

The Women's Imaging Center, Denver

80210

Porter Adventist Hospital, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

SCL Health Saint Joseph Hospital, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

Western Surgical Care, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80260

National Jewish Health-Northern Hematology Oncology, Thornton

Rocky Mountain Cancer Centers-Thornton, Thornton

80301

Boulder Community Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80401

Mountain Blue Cancer Care Center, Golden

National Jewish Health-Western Hematology Oncology, Golden

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80539

Banner McKee Medical Center, Loveland

80631

Banner North Colorado Medical Center, Greeley

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81008

Rocky Mountain Cancer Centers - Pueblo, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

81501

Saint Mary's Hospital and Regional Medical Center, Grand Junction

82001

Cheyenne Regional Medical Center-West, Cheyenne

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83301

Saint Luke's Cancer Institute - Twin Falls, Twin Falls

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83617

Walter Knox Memorial Hospital, Emmett

83619

Saint Luke's Cancer Institute - Fruitland, Fruitland

83642

Idaho Urologic Institute-Meridian, Meridian

Saint Luke's Cancer Institute - Meridian, Meridian

83686

Saint Luke's Cancer Institute - Nampa, Nampa

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83712

Saint Luke's Cancer Institute - Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

87106

Southwest Gynecologic Oncology Associates Inc, Albuquerque

University of New Mexico Cancer Center, Albuquerque

87124

Presbyterian Rust Medical Center/Jorgensen Cancer Center, Rio Rancho

89048

Hope Cancer Care of Nevada-Pahrump, Pahrump

89052

Cancer and Blood Specialists-Henderson, Henderson

Comprehensive Cancer Centers of Nevada - Henderson, Henderson

Comprehensive Cancer Centers of Nevada-Horizon Ridge, Henderson

Las Vegas Cancer Center-Henderson, Henderson

OptumCare Cancer Care at Seven Hills, Henderson

89074

Comprehensive Cancer Centers of Nevada-Southeast Henderson, Henderson

GenesisCare USA - Henderson, Henderson

89102

Desert West Surgery, Las Vegas

OptumCare Cancer Care at Charleston, Las Vegas

University Medical Center of Southern Nevada, Las Vegas

89103

Hope Cancer Care of Nevada, Las Vegas

89106

Cancer and Blood Specialists-Shadow, Las Vegas

Radiation Oncology Centers of Nevada Central, Las Vegas

Women's Cancer Center of Nevada, Las Vegas

89109

GenesisCare USA - Las Vegas, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway, Las Vegas

89113

HealthCare Partners Medical Group Oncology/Hematology-San Martin, Las Vegas

89119

Radiation Oncology Centers of Nevada Southeast, Las Vegas

89128

Ann M Wierman MD LTD, Las Vegas

Cancer and Blood Specialists-Tenaya, Las Vegas

Comprehensive Cancer Centers of Nevada - Northwest, Las Vegas

GenesisCare USA - Vegas Tenaya, Las Vegas

HealthCare Partners Medical Group Oncology/Hematology-Tenaya, Las Vegas

OptumCare Cancer Care at MountainView, Las Vegas

89144

Comprehensive Cancer Centers of Nevada - Town Center, Las Vegas

Comprehensive Cancer Centers of Nevada-Summerlin, Las Vegas

Summerlin Hospital Medical Center, Las Vegas

89148

Comprehensive Cancer Centers of Nevada, Las Vegas

GenesisCare USA - Fort Apache, Las Vegas

OptumCare Cancer Care at Fort Apache, Las Vegas

89149

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills, Las Vegas

89169

Comprehensive Cancer Centers of Nevada - Central Valley, Las Vegas

University Cancer Center, Las Vegas

89502

Renown Regional Medical Center, Reno

89503

Saint Mary's Regional Medical Center, Reno

89509

Radiation Oncology Associates, Reno

89703

Carson Tahoe Regional Medical Center, Carson City

91505

Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank

93420

PCR Oncology, Arroyo Grande

96701

Hawaii Cancer Care - Westridge, ‘Aiea

Pali Momi Medical Center, ‘Aiea

Queen's Cancer Center - Pearlridge, ‘Aiea

The Cancer Center of Hawaii-Pali Momi, ‘Aiea

96766

Wilcox Memorial Hospital and Kauai Medical Clinic, Lihue

96813

Hawaii Cancer Care Inc - Waterfront Plaza, Honolulu

Island Urology, Honolulu

Queen's Cancer Cenrer - POB I, Honolulu

Queen's Medical Center, Honolulu

Straub Clinic and Hospital, Honolulu

University of Hawaii Cancer Center, Honolulu

96817

Hawaii Cancer Care Inc-Liliha, Honolulu

Kuakini Medical Center, Honolulu

Queen's Cancer Center - Kuakini, Honolulu

The Cancer Center of Hawaii-Liliha, Honolulu

96826

Kapiolani Medical Center for Women and Children, Honolulu

97015

Clackamas Radiation Oncology Center, Clackamas

Providence Cancer Institute Clackamas Clinic, Clackamas

97132

Providence Newberg Medical Center, Newberg

97213

Providence Portland Medical Center, Portland

97225

Providence Saint Vincent Medical Center, Portland

97420

Bay Area Hospital, Coos Bay

97701

Saint Charles Health System, Bend

97756

Saint Charles Health System-Redmond, Redmond

97814

Saint Alphonsus Cancer Care Center-Baker City, Baker City

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98003

Saint Francis Hospital, Federal Way

98022

Saint Elizabeth Hospital, Enumclaw

98026

Swedish Cancer Institute-Edmonds, Edmonds

98029

Swedish Cancer Institute-Issaquah, Issaquah

98104

Pacific Gynecology Specialists, Seattle

98107

Swedish Medical Center-Ballard Campus, Seattle

98112

Kaiser Permanente Washington, Seattle

98122

Swedish Medical Center-First Hill, Seattle

98166

Highline Medical Center-Main Campus, Burien

98201

Providence Regional Cancer Partnership, Everett

98225

PeaceHealth Saint Joseph Medical Center, Bellingham

98284

PeaceHealth United General Medical Center, Sedro-Woolley

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98383

Saint Michael Cancer Center, Silverdale

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98499

Saint Clare Hospital, Lakewood

98503

Providence Regional Cancer System-Lacey, Lacey

98508

Anchorage Associates in Radiation Medicine, Anchorage

98520

Providence Regional Cancer System-Aberdeen, Aberdeen

98531

Providence Regional Cancer System-Centralia, Centralia

98584

Providence Regional Cancer System-Shelton, Shelton

98597

Providence Regional Cancer System-Yelm, Yelm

98632

PeaceHealth Saint John Medical Center, Longview

98664

PeaceHealth Southwest Medical Center, Vancouver

99336

Kadlec Clinic Hematology and Oncology, Kennewick

99362

Providence Saint Mary Regional Cancer Center, Walla Walla

99504

Anchorage Radiation Therapy Center, Anchorage

99508

Alaska Breast Care and Surgery LLC, Anchorage

Alaska Oncology and Hematology LLC, Anchorage

Alaska Women's Cancer Care, Anchorage

Anchorage Oncology Centre, Anchorage

Katmai Oncology Group, Anchorage

Providence Alaska Medical Center, Anchorage

50266-7700

Methodist West Hospital, West Des Moines

89148-2405

Las Vegas Cancer Center-Medical Center, Las Vegas

03756

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

02905

Women and Infants Hospital, Providence

98122-5711

Swedish Medical Center-Cherry Hill, Seattle

00603

Advance Oncology Center, Aguadilla

00614

Doctor's Cancer Center-Arecibo, Arecibo

00959-5060

Cancer Center-Metro Medical Center Bayamon, Bayamón

00961

Hematologia Oncologia San Pablo, Bayamón

00726

HIMA San Pablo Oncologic Hospital, Caguas

00674

Doctors Cancer Center, Manatí

00716

Instituto Oncologia Moderna Ponce, Ponce

00917

San Juan Community Oncology Group, San Juan

00920

Primary Care Physician Group, San Juan

00927

Centro Comprensivo de Cancer de UPR, San Juan

00936

San Juan City Hospital, San Juan

00757

Centro de Hematologia y Oncologia del Sur, Santa Isabel

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH