Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial

PHASE4CompletedINTERVENTIONAL
Enrollment

1,278

Participants

Timeline

Start Date

July 13, 2018

Primary Completion Date

June 9, 2022

Study Completion Date

June 9, 2023

Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG

Semaglutide

Participants will be prescribed commercially available semaglutide s.c. and will be instructed to initiate treatment with semaglutide s.c. according to the approved label. The study doctor will determine the intended maintenance dose of semaglutide, as well as changes to the maintenance dose thereafter.

DRUG

Standard of care

Participants will receive standard of care, defined as commercially available oral or injectable antidiabetic medication other than semaglutide. Participants will be prescribed and instructed to initiate commercially available antidiabetic medication according to the approved label and, if relevant for the specific antidiabetic medication, adjusted at the discretion of the study doctor.

Trial Locations (122)

10016

NYC Research, Inc., New York

NYU Grossman School of Med, New York

10704

EDOC LLP, Yonkers

11021

Northwell Health Div of Endo, Great Neck

11023

Advanced Internal Medicine Group, Great Neck

11221

Prominis Medical Services PC, Brooklyn

12203

Albany Medical College - Endo, Albany

15236

Preferred Primary Care Physicians_Pittsburgh, Pittsburgh

15317

Primary Care Research South, Inc, McMurray

19438

Harleysville Medical Associates, Harleysville

20186

Piedmont Family Practice PLC, Warrenton

22044

Seven Corners Medical, Falls Church

22205

The Endocrinology Group, Arlington

23083

Lawson Family Medicine & Aesthetics, Daleville

23435

Hampton Roads Center for Clinical Research, Suffolk

23454

Endocrinology Consultants, Virginia Beach

23462

Corporation Lane Research Center, Virginia Beach

23606

C. Lee Ginsburgh, Newport News

23666

Hampton Family Practice, Hampton

23701

Family Medicine Healthcare, Portsmouth

23834

Swift Creek Family Care, Colonial Heights

24141

Family Health Clinic, Radford

24201

PMG Research of Bristol, Bristol

24501

Medical Associates of Central Virginia, Inc., Lynchburg

24531

Chatham Family Medical Center, Chatham

24541

Privia Medical Group LLC, Danville

24592

Halifax Internal Medicine, South Boston

28210

OnSite Clinical Solutions, LLC_Charlotte_0, Charlotte

28277

OnSite Clinical Solutions, LLC_Charlotte, Charlotte

30024

Herman Clinical Research LLC, Suwanee

Sugarloaf Medical, PC, Suwanee

30047

Beaver Ruin Primary Care, Lilburn

30060

DC Research Works, Marietta

30067

Urban Family Practice Assoc, Marietta

30075

Atlanta Center for Clinical Research, Roswell

30106

The Kaufmann Clinic, Inc., Atlanta

30240

Medical Care of LaGrange, La Grange

30248

Privia Medical Group of Georgia LLC, Locust Grove

30281

Eagles Landing Diabetes/Endocrinology, Stockbridge

30312

Primary Care Research, Atlanta

30401

East Georgia Healthcare Center Inc, Swainsboro

30461

Family Health Care Center, Statesboro

30513

River Birch Research Alliance, LLC, Blue Ridge

30519

Gwinnett Research Insti/Buford Family Pract Urgent Care Ctr, Buford

31082

Sandersville Family Practice, Sandersville

31406

Meridian Clin Res, LLC, Savannah

31501

Coastal Care Medical Clinic, Waycross

31904

Centricity Research, Columbus

37110

Ascend Research Centers, Inc., McMinnville

37303

Athens Medical Group, Athens

38343

Murphy Research Center, Humboldt

40361

Paris Family Physicians PLLC, Paris

40475

Gaurang B. Shah, MD, Richmond

41011

St Elizabeth Physicians Heart, Covington

41101

Regional Endorine and Diabetes Associates, Ashland

Tri State Primary Caregrayson Health Park, Ashland

42303

The Endocrine & Diabetes Center, Owensboro

43213

Central Ohio Clinical Research LLC, Columbus

Centricity Research, Columbus

44106

University Hospitals of Cleveland Case Medical Center, Cleveland

44281

New Venture Medical Research, Wadsworth

44718

Diab & Endo Assoc of Stark Co, Canton

45005

Medical Frontiers, LLC, Carlisle

Franklin Family Practice, Franklin

Prestige Clinical Research, Franklin

45040

Functional Endocrinology, Mason

45107

Catherine LaRuffa, M.D., Inc., Blanchester

46016

St. Vincent Research Institute, Anderson

46123

American Health Network of Indiana, LLC_Avon_0, Avon

46131

American Health Network of IN LLC_Franklin, Franklin

46140

American Health Network of Indiana, LLC_Greenfield, Greenfield

46360

La Porte County Institute For Clinical Research, Michigan City

46544

Beacon Medical Group Swartz-Weikamp, Mishawaka

46711

Adams County Family Physicians, Berne

46825

Associated Surgeons & Physicians LLC, Fort Wayne

47150

American Health Network of Indiana, LLC, New Albany

47304

American Health Network of IN LLC, Muncie

47374

Reid Endocrinology Center, Richmond

47725

Deaconess Clinic, Inc., Evansville

49820

Family Care of Williamsburg, Williamsburg

53211

Ascension Medical Group- Germantown Clinic, Milwaukee

53226

Medical College of Wisconsin & Zablocki VAMC, Milwaukee

54303

St. Vincent Hosp-Prevea Health, Green Bay

58104

Valley Weight Loss Clinic, Fargo

63017

Diabetes & Endo Specialists Inc, Chesterfield

63104

Saint Louis University, St Louis

63128

South County Endocrinology and Obesity Medicine, LLC, St Louis

65109

Jefferson City Medical Group, PC, Jefferson City

65201

University Of Missouri - Columbia, Columbia

65803

Trinity Healthcare, Springfield

77478

Simcare Medical Research, LLC, Sugar Land

78130

Christus Trinity Clinic Hill Country Landa, New Braunfels

80113

Denver Endocrinology Diabetes and Thyroid Center, Englewood

80220

University of Colorado Hospital, Denver

84790

Chrysalis Clinical Research, St. George

89148

Palm Research Center Inc-Vegas, Las Vegas

90505

Adnab Research/Prestige Care Physician, Torrance

90620

American Clinical Trials, Buena Park

90720

Pacific Clinical Studies, Los Alamitos

91345

Facey Medical Foundation, Mission Hills

91602

Premier Medical Center, Inc., Toluca Lake

92835

St. Jos Heritage Hlthcr_Fllrtn, Fullerton

92844

SC Clinical Research, Inc., Garden Grove

93030

Format Medical Research, Oxnard

93274

Altura Centers For Health, Tulare

93291

Tariq Javed, MD Inc., Visalia

93534

New Hope Consulting & Clinical Trials, Lancaster

OM Research LLC, Lancaster

93940

Monterey Endocrine & Diabetes Institute, Inc, Monterey

94558

Do-Eun Lee, Napa

94598

Endocrinology & Diabetes Specialists, Walnut Creek

95035

Pacific Medical Center, Milpitas

95148

Joselito C Cabaccan, MD, San Jose

06010

ProHealth Physicians/OptumCare, Bristol

06810

Western Connecticut Health Network_Danbury, Danbury

06517

Endocrine Associates of Connecticut, Hamden

06460

Ismail Tarkhan MD, Milford

Steven L. Saunders MD LLC, Milford

04915

Southern Family Medical Center, Augusta

WCMP Family Medicine, Belfast

48310-3503

Tri-County Research, Inc., Sterling Heights

N6G 2M1

Western University Medical Center at WU of Health Sciences, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Novo Nordisk A/S

INDUSTRY

NCT03596450 - Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial | Biotech Hunter | Biotech Hunter