Effectiveness and Safety of Yisaipu Combined With Tripterygium Wilfordii for Active RA

Oral Tripterygium Wilfordii 20mg thrice daily for 24 weeks.

Oral methotrexate 7.5-15mg per week for 24 weeks. The starting dose was 7.5mg per week, then increased to 15mg (max 0.3mg/Kg) per week in 4 weeks. Folic acid at the dose of 5 mg per week were applied to all participants.

Yisaipu, a Tumor Necrosis Factor Receptor Fusion Protein, was subcutaneously injected at a dose of 50 mg once a week for 24 weeks.