A Study of Ponatinib Versus Imatinib in Adults With Acute Lymphoblastic Leukemia

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

245

Participants

Timeline

Start Date

October 4, 2018

Primary Completion Date

August 12, 2022

Study Completion Date

July 31, 2027

Conditions
Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia (Ph+ALL)
Interventions
DRUG

Ponatinib

Ponatinib Tablets.

DRUG

Imatinib

Imatinib Tablets.

DRUG

Vincristine

Vincristine IV injection.

DRUG

Dexamethasone

Dexamethasone Tablets.

DRUG

Cytarabine

Cytarabine IV infusion.

DRUG

Methotrexate

Methotrexate IV infusion.

DRUG

Prednisone

Prednisone Tablets.

Trial Locations (92)

970

Hualien Tzu Chi Hospital, Hualien City

1090

Universitaetsklinik Fuer Innere Medizin I, Vienna

1140

Hanusch Krankenhaus Wiener Gebietskrankenkasse, Vienna

1431

University Multiprofile Hospital for Active Treatment Saint Ivan Rilski, Sofia

2065

Royal North Shore Hospital, Saint Leonards

3128

Box Hill Hospital, Box Hill

3168

Monash Medical Centre, Clayton

4020

Ordensklinikum Linz Elisabethinen, Linz

10676

Evaggelismos General Hospital, Athens

11042

Monter Cancer Center, New Hyde Park

11794

Stony Brook University Medical Center, Stony Brook

12462

University General Hospital of Athens Attikon, Chaïdári

14263

Roswell Park Cancer Institute, Buffalo

16132

Azienda Policlinico San Martino, Genoa

16247

The Catholic University of Korea St. Vincent's Hospital, Suwon

20090

Azienda Ospedaliera San Gerardo di Monza, Monza

20132

Istituto Scientifico Universitario San Raffaele, Milan

21201

University of Maryland Medical Center, Baltimore

26504

University General Hospital of Patras Panagia I Voithia, Patra

30174

Ospedale dell'Angelo, Mestre

30912

Augusta University Georgia Cancer Center, Augusta

31059

Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse

35294

University of Alabama at Birmingham, Birmingham

37007

Hospital Universitario de Salamanca, Salamanca

40138

Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi, Bologna

40447

China Medical University Hospital, Taichung

41124

Azienda Ospedaliero-Universitaria di Modena Policlinico, Modena

41944

Kyungpook National University Hospital, Daegu

42123

Arcispedale Santa Maria Nuova, Reggio Emilia

42415

Yeungnam University Hospital, Daegu

46026

Hospital Universitari i Politecnic La Fe de Valencia, Valencia

46202

Indiana University, Indianapolis

46237

Indiana Blood & Marrow Transplantation, Indianapolis

47014

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola

48108

Inje University Haeundae Paik Hospital, Busan

48121

Azienda USL della Romagna, Ravenna

49933

Center Hospitalier Universitaire d'Angers, Angers

54907

Chonbuk National University Hospital, Jeonju

64460

Hospital Universitario Dr. Jose Eleuterio Gonzalez, Monterrey

66160

University of Kansas Medical Center Research Institute, Kansas City

69495

Centre Hospitalier Lyon Sud, Pierre-Bénite

70403

National Cheng Kung University Hospital, Tainan City

73100

Azienda Ospedaliera Vito Fazzi, Lecce

77030

The University of Texas MD Anderson Cancer Center, Houston

78157

Centre Hospitalier de Versailles Hopital Andre Mignot, Le Chesnay

78229

Methodist Hospital, San Antonio

90095

University of California Los Angeles, Los Angeles

90146

Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo

91010

City of Hope - Duarte, Duarte

97239

Oregon Health and Science University, Portland

125167

National Research Center for Hematology, Dept. of Hematology/Oncology and BMT, Moscow

127644

City Clinical Hospital named after Vikentiy Vikentyevich Veresaev, Moscow

130021

The First Hospital of Jilin University, Changchun

197341

Almazov Federal North-West Medical Research Centre of Department of Health of Russian Federation, Saint Petersburg

215006

The First Affiliated Hospital of Soochow University/Suzhou First People's Hospital, Suzhou

300041

Institute of Hematology & Blood Diseases Hospital of CAMS & PUMC, Tianjin

310003

The First Affiliated Hospital, Zhejiang University, Hangzhou

450008

Henan Cancer Hospital, Zhengzhou

620102

Sverdlovsk Regional Clinical Hospital #1, Yekaterinburg

07601

Hackensack University Medical Center, Hackensack

X5000JHQ

Sanatorio Allende, Córdoba

X5014KEH

Hospital Privado Centro Medico de Cordoba, Córdoba

41253-190

Hospital Sao Rafael-Monte Tabor, Salvador

81520-060

Hospital Erasto Gaertner, Curitiba

99010-260

Hospital da Cidade, Passo Fundo

90035-003

Hospital de Clinicas de Porto Alegre, Porto Alegre

130383-878

Hemocentro Campinas Unicamp, Campinas

17210-120

Fundacao Doutor Amaral Carvalho, Jaú

14048-900

Hospital das Clinicas da Faculdade de Medicina da Riberao Preto da Universidade de Sao Paulo, Ribeirão Preto

20211-030

HEMORIO Instituto Estadual de Hematologia, Rio de Janeiro

01246-000

Instituto do Cancer do Estado de Sao Paulo, São Paulo

01509-900

Fundacao Antonio Prudente - A.C.Camargo Cancer Center, São Paulo

V5Z 1M9

855 West 12th Avenue, Vancouver

K1H 8L6

The Ottawa Hospital, Ottawa

J4V 2H1

Hopital Charles-LeMoyne, Greenfield Park

H1T 2M4

Hopital Maisonneuve-Rosemont, Montreal

00029 HUS

Helsingin ja Uudenmaan sairaanhoitopiiri, Helsinki

00161

Centro di Ematologia Policlinico Umberto I Universita Sapienza di Roma, Roma

00168

Fondazione Policlinico Universitario Agostino Gemelli, Roma

277-8577

National Cancer Center Hospital East, Kashiwa-shi

064-0804

Aiiku Hospital, Sapporo

259-1193

Tokai University Hospital, Isehara

700-8558

Okayama University Hospital, Okayama

260-0852

Chiba Aoba Municipal Hospital, Chiba

960-1295

Fukushima Medical University Hospital, Fukushima

31-501

Szpital Uniwersytecki w Krakowie, Krakow

50-367

Uniwersytecki Szpital Kliniczny we Wroclawiu, Wroclaw

80-214

Uniwersyteckie Centrum Kliniczne, Gdansk

10-228

Samodzielny Publiczny Zaklad Opieki Zdrowotnej Ministerstwa Spraw Wewnetrznych z Warminsko-Mazurs, Olsztyn

08916

Institut Catala d'Oncologia Badalona - Hospital Germans Trias i Pujol, Badalona

08035

Hospital Universitari Vall d'Hebron, Barcelona

06590

Ankara Universitesi Tp Fakultesi, Ankara

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Takeda

INDUSTRY