Study of Environmental Enteropathy and Malnutrition in Pakistan

NACompletedINTERVENTIONAL
Enrollment

416

Participants

Timeline

Start Date

March 1, 2016

Primary Completion Date

July 31, 2019

Study Completion Date

July 31, 2019

Conditions
Malnutrition, ChildEnteropathyVaccine Response ImpairedStuntingGastrointestinal Disease
Interventions
OTHER

Nutritional education

4 week home delivered educational program that will focus on breast feeding and complimentary feeding. If child remains WHZ \< -2 at by 9 months of age families will be shown 10 minute educational video detailing best practices for complimentary feeding.

DIETARY_SUPPLEMENT

Ready to Use Therapeutic Food

If child remains WHZ \< -2 despite nutritional education then will be managed according to Pakistan's Community Management of Acute Malnutrition protocol. This will include provision of ready to use therapeutic food (RUTF) to the child at home with close follow up. Utilization of the RUTF will be monitored closely by bi-weekly home visits.

PROCEDURE

Upper gastrointestinal endoscopy with biopsy

If child remains at WHZ \< -2 despite educational and dietary interventions, then will undergo medical evaluation for assessment of need for more advanced workup of malnutrition, including UGI endoscopy at AKUH. Results of the advanced work up, including the UGI endoscopy, will guide future management of these children.

Trial Locations (1)

74800

Aga Khan University, Karachi

All Listed Sponsors
collaborator

University of Virginia

OTHER

collaborator

Children's Hospital Medical Center, Cincinnati

OTHER

collaborator

Bill and Melinda Gates Foundation

OTHER

collaborator

Washington University School of Medicine

OTHER

collaborator

Massachusetts General Hospital

OTHER

lead

Aga Khan University

OTHER

NCT03588013 - Study of Environmental Enteropathy and Malnutrition in Pakistan | Biotech Hunter | Biotech Hunter