QUILT-3.080: NANT Pancreatic Cancer Vaccine

PHASE1/PHASE2TerminatedINTERVENTIONAL
Enrollment

3

Participants

Timeline

Start Date

July 17, 2018

Primary Completion Date

April 17, 2019

Study Completion Date

August 1, 2019

Conditions
Pancreatic Cancer
Interventions
DRUG

Aldoxorubicin HCl

Aldoxorubicin Hydrochloride

BIOLOGICAL

ALT-803

Recombinant human super agonist interleukin-15 (IL-15) complex

BIOLOGICAL

ETBX-011

Ad5 \[E1-, E2b-\]-CEA

BIOLOGICAL

ETBX-021

Ad5 \[E1-, E2b-\]-HER2

BIOLOGICAL

ETBX-051

Ad5 \[E1-, E2b-\]-Brachyury

BIOLOGICAL

ETBX-061

Ad5 \[E1-, E2b-\]-MUC1

BIOLOGICAL

GI-4000

RAS yeast

BIOLOGICAL

GI-6207

Carcinoembryonic Antigen (CEA) yeast

BIOLOGICAL

GI-6301

Brachyury yeast

BIOLOGICAL

haNK for infusion

NK-92 \[CD16.158V, ER IL-2\]

BIOLOGICAL

bevacizumab

Recombinant human anti-Vascular Endothelial Growth Factor (VEGF) IgG1 monoclonal

DRUG

Capecitabine

5'-deoxy-5-fluoro-N-\[(pentyloxy) carbonyl\]-cytidine

DRUG

Cyclophosphamide

2-\[bis(2-chloroethyl)amino\]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate

DRUG

Fluorouracil

5-fluoro-2,4 (1H,3H)-pyrimidinedione

DRUG

Leucovorin

L-Glutamic acid, N-\[4-\[\[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl\]amino\]benzoyl\]-, calcium salt

DRUG

nab-Paclitaxel

Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-(2aR, 4S, 4aS, 6R, 9S, 11S, 12S, 12aR, 12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a, 3, 4, 4a, 5, 6, 9, 10, 11, 12, 12a, 12b-dodecahydro-4,11-dihydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca\[3,4\]benz\[1,2-b\]oxet-9-y1ester,(αR,βS)-(9CI) bound to albumin

DRUG

Oxaliplatin

cis-\[(1 R,2 R)-1,2-cyclohexanediamine-N,N'\] \[oxalato(2-)- O,O'\] platinum

BIOLOGICAL

Avelumab

Recombinant human anti-programmed death-ligand 1 (PD-L1) IgG1 monoclonal antibody

PROCEDURE

SBRT

Stereotactic Body Radiation Therapy

Trial Locations (1)

90245

Chan Soon-Shiong Institute for Medicine, El Segundo

Sponsors

Lead Sponsor

All Listed Sponsors
lead

ImmunityBio, Inc.

INDUSTRY

NCT03586869 - QUILT-3.080: NANT Pancreatic Cancer Vaccine | Biotech Hunter | Biotech Hunter