Clinical Research Study With Clazosentan to Evaluate Its Effects on Preventing Complications Due to the Narrowing of the Blood Vessels (Vasospasm) in the Brain, Caused by Bleeding Onto the Surface of the Brain

PHASE3CompletedINTERVENTIONAL
Enrollment

409

Participants

Timeline

Start Date

February 3, 2019

Primary Completion Date

June 13, 2022

Study Completion Date

November 18, 2022

Conditions
Aneurysmal Subarachnoid Hemorrhage
Interventions
DRUG

Clazosentan

Clazosentan will be administered as a continuous intravenous infusion at the dose of 15 mg/hour for up to 14 days.

DRUG

Placebo

Placebo will be administered at the same infusion rate as clazosentan for up to 14 days.

Trial Locations (80)

1070

Hospital Erasme, Service de Soins Intensifs, Brussels

1200

Hospital - Cliniques Universitaires Saint-Luc, Service de Neurochirurgie, Brussels

4000

University Hospital Sart Tilman Liege, Liège

4032

Debreceni Egyetem, Idegsebészet, Debrecen

5000

Odense Universitets Hospital Neurokirurgisk afdelning, Odense

6020

Medizinische Universität Innsbruck; Universitätsklinik für Neurologie und Psychiatrie, Innsbruck

7623

Pécsi Tudományegyetem Klinikai Központ, Idegsebészeti Klinika, Pécs

9000

Neurology Department, University Hospital, Ghent

10029

Mt Sinai Hospital, New York

10032

Columbia University Medical Center Dept. of Neurology - Neurological Intensive Care Unit, New York

10117

Charite Universitätsmedizin Berlin - Klinik und Poliklinik für Neurochirurgie, Berlin

11030

Northwell Health, Department of Neurosurgery, Manhasset

13385

Hôpital de la Timone 2, Intensive Care Unit SAR 1, Marseille

17033

Penn State Milton S Hershey Medical Center, Neurosurgery, Hershey

18057

Universitätsklinikum Rostock, Abteilung für Neurochirurgie, Rostock

20099

Asklepios Klinik St. Georg - Neurochirugie, Hamburg

20246

University Hospital of Hamburg-Eppendorf, Dpt. of Neurosurgery, Hamburg

20520

Turku University Hospital Neurosurgery, T-hospital, Turku

20900

ASST Monza, Hospital San Gerardo, TERAPIA INTENSIVA Neurochirurgica, Monza

21201

University of Maryland Medical Systems - Neurosurgery, Baltimore

22185

Lunds Universitetssjukhus, Neurokirurgiska avd. NIVA, Lund

23298

Virginia Commonwealth University, Department of Neurosurgery, Richmond

23538

Universitätsklinikum Schleswig Hollstein Lübeck (UKSH) Klinik für Neurochirugie, Lübeck

28041

Hospital Universitario 12 de Octubre, Departamento Neurosurgery Division Neuroradiology, Madrid

31059

Univ Hosp Toulouse, University Hospital Purpan Pierre Paul Riquet Hospital, Toulouse

32224

Mayo clinic, Dept of Neurosurgery, Jacksonville

33520

Tampereen yliopistollinen sairaala Neurokirurgian klinika, Tampere

35010

University Hospital of Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria

35128

Azienda Ospedaliera Padova-Università degli Studi di Padova - Istituto di Anestesia e Rianimazione, Padua

37232

Vanderbilt University Medical Center - Department of Neurosurgery, Nashville

40225

Heinrich-Heine Universität Düsseldorf -Klinik für Neurochirugie, Düsseldorf

41345

Sahlgrenska Universitetssjukhuset, Verksamheten för neurokirurgi, Neurosjukvården, Gothenburg

43126

Azienda Ospedaliero Universitaria di Parma, struttura complessa Neurochirurgia, Parma

43210

The Ohio State University - Wexner Medical Center, Columbus

44093

Hôpital Nord Laennec - CHU de Nantes, Nantes

44106

University Hospitals Case Medical Center - Department of Neurosurgery, Cleveland

45147

University Hospital of Essen, Department of Neurosurgery, Essen

58185

Linköping Universitetssjukhuset, Neurokirurgiska kliniken, Linköping

60528

Universitätsklinik Frankfurt, Klinik und Poliklinik für Neurochirurgie, Dept of neurosurgery, Frankfurt

60612

University of Illinois - Department of Neurosurgery, Chicago

63003

Hôpital Gabriel Montpied, ICU DEPT, Neuro reanimation departement, Clermont-Ferrand

69006

Hôpital neurologique Pierre Wertheimer Service de Reanimation, Bron

69120

Neurochirurgische Universitätklinik des Heidelberg, Dept of Neurosurgery, Heidelberg

70210

Kuopio University Hospital, Kuopio

73104

Oklahoma University Health Sciences Center - Department of Neurology, Oklahoma City

75010

Hospital Lariboisiere Paris, Paris

75013

Hôpital Pitié-Salpêtrière, Service de neuroréanimation chirurgicale Babinski, Paris

86156

Klinik für Diagnostische Radiologie und Neuroradiologie, Augsburg, Augsburg

89132

Bezirkskrankenhaus Günzburg - Klinik für Neurochirugie, Günzburg

91054

University of Erlangen-Nürnberg, Dpt. of Neurosurgery, Erlangen

93053

University Regensburg, Dpt. of Neurosurgery, Regensburg

94305

Stanford Hospital & Clinics - Stanford School of Medicine Dept. of Neurosurgery, Stanford

97239

Oregon Health and Science University, Portland

3109601

Rambam Healthcare Campus, Neurology Department, Haifa

4941492

Beilinson Hospital, Rabin Medical Center, Department of Neurosurgery, Petah Tikva

5265601

The Chaim Sheba Medical Centre - Neurosurgery, Ramat Gan

9112001

Hadassah Medical Center, Jerusalem

02118

Boston University School of Medicine / Boston University Medical Center, Boston

02215

Beth Israel Deaconess Medical Center Dept of Neurosurgery, Boston

A-4020

Kepler Universitätsklinikum, Universitätsklinik für Neurochirurgie, Linz

T6G 2B7

University of Alberta Hospital Department of Neurological Surgery, Edmonton

R3A 1R9

Winnipeg Regional Health Authority Health Sciences Centre, Winnipeg

B3H 3A7

Halifax Infirmary, Nova Scotia Health Authority, Halifax

S7N 0W8

Royal University Hospital Department of Neurology, Saskatoon

625 00

Fakultní nemocnice Brno Neurochirurgická klinika, Brno

708 52

Fakultní nemocnice Ostrava Neurochirurgická klinika, Ostrava-Poruba

304 60

University Hospital in Pilsen, Department of Neurosurgery, Pilsen

169 02

Ústřední vojenská nemocnice Praha Neurochirurgická klinika, Prague

401 13

Masarykova nemocnice v Ústí nad Labem Neurochirurgie, Ústí nad Labem

00260

Helsingin yliopistollinen keskussairaala Neurokirurgian klinikka, Helsinki

00168

Fondazione Policlinico Universitario Agostino Gemelli Università Cattolica del Sacro Cuore, UOS Terapia Intensiva Neurochirurgic, Rome

90-153

Uniwersytecki Szpital Kliniczny nr 1 im. Norberta Barlickiego, Lodz

60-355

Oddział Neurochirurgii i Neurotraumatologii z Pododdziałem Leczenia Chorób Naczyniowych Centralnego Układu Nerwowego, Poznan

02-097

Katedra i Klinika Neurochirurgii Samodzielny Publiczny Centralny Szpital Kliniczny w Warszawie, Warsaw

08916

Hospital Universitario Germans Trias i Pujol - Neurology Department, Badalona

08035

Hospital Vall d'Hebron Departamento Neuroradiología, Barcelona

08036

Hospital Clinic Barcelona, Barcelona

08907

Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat

07014

Hospital Universitari son Espases, Palma de Mallorca

08208

Corporació Sanitària Parc Taulí, Hospital Parc Taulí, Sabadell

Sponsors
All Listed Sponsors
lead

Idorsia Pharmaceuticals Ltd.

INDUSTRY