Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination

PHASE3CompletedINTERVENTIONAL
Enrollment

4,939

Participants

Timeline

Start Date

August 11, 2018

Primary Completion Date

December 31, 2019

Study Completion Date

July 31, 2021

Conditions
Malaria
Interventions
DRUG

dihydroartemisinin-piperaquine (DP)

DP will be available as tablets of 320/40mg and 160/20mg piperaquine/ dihydroartemisinin per tablet. Administration of a full course of DP will be done as per manufacturer's guidelines once daily for 3 days and according to body weight. DP will be taken orally with water and without food

DRUG

ivermectin (IVM)

IVM will be available as tablets of 3mg or 6mg strength. It will be given at 300-400μg/kg/day over 3 days (to the nearest whole tablet). IVM will also be taken on an empty stomach with water

OTHER

standard malaria control interventions only

this is the standard malaria control interventions in the Gambia

Trial Locations (1)

Unknown

Basse Villages, Basse Santa Su

All Listed Sponsors
collaborator

Institute of Tropical Medicine, Belgium

OTHER

collaborator

National Malaria Control Programme, The Gambia

OTHER_GOV

collaborator

Liverpool School of Tropical Medicine

OTHER

collaborator

Radboud University Medical Center

OTHER

collaborator

University of Durham

OTHER

collaborator

Imperial College London

OTHER

lead

London School of Hygiene and Tropical Medicine

OTHER

NCT03576313 - Mass Drug Administration of Ivermectin and Dihydroartemisinin-piperaquine as an Additional Intervention for Malaria Elimination | Biotech Hunter | Biotech Hunter