The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence

NACompletedINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

February 12, 2018

Primary Completion Date

December 1, 2019

Study Completion Date

June 1, 2020

Conditions
Opioid DependenceObesity
Interventions
BEHAVIORAL

Sniffin' Sticks Odor Identification and Hedonic Scale

This task measures odor identification accuracy and perceived pleasantness of odors.

BEHAVIORAL

Sucrose Taste Preference Assessment

This task measures participant ratings of sucrose preference.

BEHAVIORAL

Food Preferences Task

Participants rate images of various food stimuli. Variables derived include relative preferences and reaction time (in milliseconds).

BEHAVIORAL

Progressive Ratio (PR) Task

In the PR task, the subject is required to make an increasing number of operant responses for each successive reward

PROCEDURE

Clinical Electrophysiology

To examine motivated attention in response to food stimuli, brain electrophysiology via event related potentials (ERPs) will be assessed while participants view and rate images of food and non-food items.

DIETARY_SUPPLEMENT

Standardized Meal and Hunger and Satiety Ratings

Participants will receive a standardized meal and complete hunger and satiety ratings.

Trial Locations (2)

21205

Broadway Center for Addictions, Baltimore

21287

Johns Hopkins Hospital, Baltimore

All Listed Sponsors
collaborator

Mid-Atlantic Nutrition Obesity Research Center

UNKNOWN

collaborator

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NIH

lead

Johns Hopkins University

OTHER

NCT03575273 - The Impact of Methadone Maintenance Therapy on Food Reward Processing in Opioid Dependence | Biotech Hunter | Biotech Hunter