Impact of Early Low-Calorie Low-Protein Versus Standard Feeding on Outcomes of Ventilated Adults With Shock

NACompletedINTERVENTIONAL
Enrollment

3,044

Participants

Timeline

Start Date

July 5, 2018

Primary Completion Date

December 16, 2020

Study Completion Date

December 24, 2021

Conditions
Critical IllnessShockMechanical VentilationCritical Illness MyopathyNosocomial Infection
Interventions
PROCEDURE

low-calorie low-protein

In the low-calorie low-protein (Low) group, the calorie target will be 6 kcal/kg/day and the protein target 0.2-0.4 g/kg/d during the acute phase, i.e. from D0 to D7. On D8, the calorie target will be 30 kcal/kg/d and the protein target 1.2-2.0 g/kg/d.

PROCEDURE

standard-calorie/standard-protein

In the standard-calorie/standard-protein (Standard) group, the first-line calorie target calculated based on body weight is 25 kcal/kg/day and the protein target 1.0-1.3 g/kg/d during the acute phase, i.e. from D0 to D7. On D8, the calorie target will be 30 kcal/kg/d and the protein target 1.2-2.0 g/kg/d.

Trial Locations (59)

12027

C.H. de Rodez Hopital Jacques Puel, Rodez

16959

Centre Hospitalier D'Angouleme, Angoulême

21079

Chu Bocage, Dijon

22000

CH Saint Brieuc, Saint-Brieuc

25030

Chu Jean Minjoz, Besançon

28630

Ch Chartres Louis Pasteur, Chartres

29609

CHU Cavale Blanche, Brest

33000

Hopital Pellegrin Chu, Bordeaux

34295

Hopital Saint Eloi, Montpellier

35033

C.H.R. Pontchaillou, Rennes

35403

Hopital Broussais, St-Malo

37044

CHU DE TOURS Bretonneau, Tours

38043

Hôpital Michalon, Grenoble

42270

CHU de Saint Etienne, Saint-Priest-en-Jarez

43000

CH Emile Roux, Le Puy-en-Velay

44000

Chu de Nantes, Nantes

44093

CHU Nantes, Nantes

49100

CHU Angers, Angers

56017

Centre Hospitalier Bretagne Atlantique - Vannes Auray, Vannes

59037

Chr - Hopital Roger Salengro, Lille

59300

CH Valenciennes, Valenciennes

59462

CH Saint-Philibert, Lomme

60000

Hôpital du bois brulé, Beauvais

62300

Centre Hospitalier de Lens, Lens

62408

Hôpital de Béthune, Béthune

63003

Chu Gabriel Montpied, Clermont-Ferrand

64000

CH Pau, Pau

65013

CH de Bigorre, Tarbes

67098

Hôpital de Hautepierre CHU de Strasbourg, Strasbourg

69317

Hopital de La Croix-Rousse, Lyon

69437

Hopital Edouard Herriot, Lyon

72037

Centre Hospitalier Du Mans, Le Mans

74374

Ch Annecy-Genevois, Annecy

75010

Hopital Lariboisiere, Paris

Hôpital Saint Louis (AP-HP), Paris

75012

Hopital Saint Antoine, Paris

75013

Hopital Pitie Salpetriere, Paris

75014

CHU Paris Cochin, Paris

75877

G.I.H. Bichat / Claude Bernard (Ap-Hp), Paris

75908

Hopital Europeen Georges Pompidou, Paris

76038

Hopital Charles Nicolle Chu Rouen, Rouen

76202

Ch Dieppe, Dieppe

77011

Centre Hospitalier Marc Jacquet, Melun

80054

Chu Amiens Picardie, Amiens

82013

Centre Hospitalier de Montauban, Montauban

85025

Chd Les Oudairies, La Roche-sur-Yon

86021

Chu La Miletrie, Poitiers

86709

Chr D'Orleans, Orléans

90015

Hôpital Nord Franche Comté, Belfort

92150

Hopital Foch, Suresnes

92380

Hôpital Raymond-Poincaré, Garches

92701

Hopital Louis Mourier (Ap-Hp), Colombes

93000

Hôpital Avicenne AP-HP, Bobigny

93100

Ctre Hosp Intercomm Andre Gregoire, Montreuil

93205

Ch General Delafontaine, Saint-Denis

94270

Chu Bicetre, Le Kremlin-Bicêtre

95100

Centre Hospitalier D'Argenteuil, Argenteuil

97159

CHU Pointe à Pitre - Abymes, Pointe-à-Pitre

97405

Chu de La Reunion Site Nord, Saint-Denis

All Listed Sponsors
collaborator

Ministry of Health, France

OTHER_GOV

collaborator

University Hospital, Tours

OTHER

lead

Nantes University Hospital

OTHER

NCT03573739 - Impact of Early Low-Calorie Low-Protein Versus Standard Feeding on Outcomes of Ventilated Adults With Shock | Biotech Hunter | Biotech Hunter