Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors

PHASE2TerminatedINTERVENTIONAL
Enrollment

202

Participants

Timeline

Start Date

June 18, 2018

Primary Completion Date

March 28, 2022

Study Completion Date

February 3, 2023

Conditions
Locally Advanced or Metastatic Solid TumorsGenes, BRCA 1
Interventions
DRUG

Avelumab

IV treatment

DRUG

Talazoparib

Oral treatment

Trial Locations (100)

1000

Institut Jules Bordet, Brussels

1090

UZ Brussel, Brussels

2100

Rigshospitalet, Copenhagen

2650

Universitair Ziekenhuis Antwerpen, Edegem

5000

Odense University Hospital, Odense C

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

Laura and Isaac Perlmutter Cancer Center, New York

NY Investigational Pharmacy, New York

NYU Langone Medical Center, New York

NYU Langone Radiology - 32nd Street, New York

10017

NYU Langone Radiology Ambulatory Care Center East 41st Street, New York

10021

Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street)., New York

10022

Rockefeller Outpatient Center, New York

Rockefeller Outpatient Pavilion (53rd Street), New York

10065

Evelyn H. Lauder Breast and Imaging Center, New York

Memorial Hospital, New York

Memorial Sloan Kettering Cancer Center, New York

10601

White Plains Hospital, White Plains

10604

Memorial Sloan Kettering Cancer Center- Westchester, Harrison

11101

Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy, Long Island City

15213

Magee-Women's Hospital Women's Cancer Center, Pittsburgh

15232

UPMC Hillman Cancer Center Investigational Drug Service, Pittsburgh

UPMC Hillman Cancer Center, Pittsburgh

17000

Groupe Hospitalier La Rochelle-Ré-Aunis, La Rochelle

19104

Hospital of the University of Pennsylvania/Penn Investigational Drug Services, Philadelphia

Hospital of the University of Pennsylvania, Philadelphia

Penn IDS Central, Philadelphia

20133

Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan

20141

Istituto Europeo di Oncologia, Istituto di Ricovero e Cura a Carattere Scientifico, Milan

20900

Azienda Socio-Sanitaria Territoriale Monza, Ospedale San Gerardo, Monza

28009

H.G.U. Gregorio Maranon, Madrid

28027

Clinica Universidad de Navarra, Madrid

28040

H.U. Fundación Jiménez Díaz, Madrid

30005

Atlanta Cancer Care -Alpharetta, Alpharetta

30033

Atlanta Cancer Care - Decatur, Decatur

Northside Hospital, Inc.-GCS/Stemmer, Decatur

30041

Atlanta Cancer Care - Cumming, Cumming

30060

Northside Hospital, Inc.-GCS/Kennestone, Marietta

30114

Northside Hospital, Inc. - GCS/Canton, Canton

30236

Atlanta Cancer Care - Stockbridge, Jonesboro

30341

Northside Hospital, Inc. - GCS/Annex, Atlanta

30342

Atlanta Cancer Care - Atlanta, Atlanta

Northside Hospital, Inc. - Central Research Department, Atlanta

Northside Hospital, Inc. - GCS/Northside, Atlanta

30606

Northside Hospital, Inc. - GCS/Athens, Athens

31217

Northside Hospital, Inc.-GCS/Macon, Macon

34298

Institut Regional du Cancer de Montpellier - ICM Val d'Aurelle, Montpellier

37055

Tennessee Oncology, PLLC, Dickson

37066

Tennessee Oncology, PLLC, Gallatin

37067

Tennessee Oncology, PLLC, Franklin

37076

Tennessee Oncology, PLLC, Hermitage

37090

Tennessee Oncology, PLLC, Lebanon

37129

Tennessee Oncology, PLLC, Murfreesboro

37160

Tennessee Oncology, PLLC, Shelbyville

37167

Tennessee Oncology, PLLC, Smyrna

37203

Tennessee Oncology, PLLC, Nashville

The Sarah Cannon Research Institute, Nashville

37205

Tennessee Oncology, PLLC, Nashville

37207

Tennessee Oncology, PLLC, Nashville

37211

Tennessee Oncology, PLLC, Nashville

37311

Tennessee Oncology, PLLC, Cleveland

37404

Tennessee Oncology, PLLC, Chattanooga

The Sarah Cannon Research Institute, Chattanooga

41014

Hospital Universitario Virgen de Valme, Seville

43026

OSU Gynecologic Oncology at Mill Run, Hilliard

43210

The Ohio State University Wexner Medical Center, Columbus

The Ohio State University, Columbus

43212

Stephanie Spielman Comprehensive Breast Cancer, Columbus

43221

Martha Morehouse Medical Plaza, Columbus

47014

IRCCS-Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola

60123

Presidio AO-U, Ospedali Riuniti Umberto I - G.M. Lancisi - G. Salesi, Torette Di Ancona

63000

Centre Jean Perrin, Clermont-Ferrand

63110

Barnes-Jewish Hospital, St Louis

Washington University Infusion Center Pharmacy, St Louis

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center - South County, St Louis

63136

Siteman Cancer Center - North County, St Louis

63141

Siteman Cancer Center - West County, Creve Coeur

63376

Siteman Cancer Center - St.Peters, City of Saint Peters

70121

Ochsner Clinic Foundation, New Orleans

73104

Stephenson Cancer Center, Oklahoma City

77030

The University of Texas, Houston

80131

Fondazione Pascale, IRCCS, Istituto Nazionale dei Tumori, Napoli

94304

Stanford Cancer Center, Palo Alto

Stanford Women's Cancer Center, Palo Alto

94305

Stanford Healthcare, Stanford

Stanford University School of Medicine, Stanford

02115

Brigham and Women's Hospital, Boston

02215

Dana Farber Cancer institute, Boston

07748

Memorial Sloan Kettering Cancer Center- Monmouth, Middletown

00161

Azienda Policlinico Umberto I, Universita La Sapienza, Oncologia B, Roma

00168

Fondazione Policlinico Universitario Agostino Gemelli Unità di Farmacologia Clinica, Roma

277-8577

National Cancer Center Hospital East, Kashiwa

541-8567

Osaka International Cancer Institute, Osaka

104-0045

National Cancer Center Hospital, Chuo-ku

1081 HV

Amsterdam University Medical Centre, location VUmc, Amsterdam

3015 GD

Erasmus Universitair Medisch Centrum, Rotterdam

08035

Hospital Universitario Vall d'Hebron, Barcelona

EC1A 7BE

Barts Health NHS Trust, St Bartholomew's Hospital, London

W1G 6AD

Sarah Cannon Research Institute UK, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT03565991 - Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors | Biotech Hunter | Biotech Hunter