A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

190

Participants

Timeline

Start Date

July 2, 2018

Primary Completion Date

March 27, 2023

Study Completion Date

March 27, 2023

Conditions
Advanced Solid Tumors
Interventions
DRUG

ASP1948

Intravenously (IV)

DRUG

nivolumab

Intravenously (IV)

DRUG

pembrolizumab

Intravenously (IV)

Trial Locations (42)

10029

Icahn School of Medicine at Mount Sinai, New York

15232

UPMC- Hillman Cancer Center, Pittsburgh

21153

Cancer Center at Greater Baltimore Medical, Baltimore

22031

Virginia Cancer Care Specialist, PC, Fairfax

29425

University of South Carolina, Charleston

37203

Sarah Cannon Research Institute - SCRI, Nashville

37232

Henry-Joyce Cancer Center, Nashville

40202

Norton Cancer Institute, Louisville

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

63110

Washington University, St Louis

68310

Oncology Hematology West P.C. dba Nebraska Cancer Specialists, Omaha

73104

University of Oklahoma, Oklahoma City

75230

Mary Crowley Cancer Research Center, Dallas

78229

South Texas Accelerated Research Therapeutics, San Antonio

89169

Comprehensive Cancer Centers of Nevada, Las Vegas

98109

University of Washington-Seattle Cancer Care Alliance, Seattle

06520-8028

Yale Center for Clinical Investigation, New Haven

Unknown

Site CA15002, Edmonton

Site CA15004, Montreal

Site IT39008, Milan

Site IT39006, Modena

Site JP81002, Chiba

Site JP81001, Tokyo

Site PT35104, Porto

Site KR82001, Seoul

Site KR82002, Seoul

Site KR82003, Seoul

Site KR82004, Seoul

Site KR82005, Seoul

Site KR82006, Seoul

Site KR82007, Seoul

Site ES34002, Barcelona

Site ES34006, Barcelona

Site ES34010, Barcelona

Site ES34014, Barcelona

Site ES34003, Cataluna

Site ES34004, Cataluna

Site ES34007, Madrid

Site ES34012, Madrid

Site TW88601, Taipei

Site TW88602, Taipei

Site GB44006, Manchester

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Astellas Pharma Global Development, Inc.

INDUSTRY

NCT03565445 - A Study of ASP1948, Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors | Biotech Hunter | Biotech Hunter