QUILT-3.088: NANT Pancreatic Cancer Vaccine

PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

August 31, 2018

Primary Completion Date

December 30, 2019

Study Completion Date

February 9, 2022

Conditions
Metastatic Pancreatic Cancer
Interventions
DRUG

Gemcitabine

Gemcitabine is a type of chemotherapy medication used to interfere with the cancer cells' ability to grow and divide.

DRUG

Nab-paclitaxel

NAB-paclitaxel is a type of chemotherapy called a microtubule inhibitor. Microtubule inhibitors interfere with a cancer cell's ability to grow and divide.

DRUG

Aldoxorubicin HCl

Albumin-binding prodrug of doxorubicin HCl

BIOLOGICAL

ALT-803

Recombinant human super agonist interleukin-15 (IL-15) complex

BIOLOGICAL

ETBX-011

Ad5 \[E1-, E2b-\]-CEA

BIOLOGICAL

ETBX-021

Ad5 \[E1-, E2b-\]-human epidermal growth factor receptor 2 \[HER2\] vaccine

BIOLOGICAL

ETBX-051

Ad5 \[E1-, E2b-\]-Brachyury vaccine

BIOLOGICAL

ETBX-061

Ad5 \[E1-, E2b-\]-mucin 1\[MUC1\]

BIOLOGICAL

GI-4000

Vaccine derived from recombinant Saccharomyces cerevisiae yeast expressing mutant Ras proteins

BIOLOGICAL

GI-6207

CEA yeast vaccine

BIOLOGICAL

GI-6301

Brachyury yeast vaccine

BIOLOGICAL

haNK

NK-92 \[CD16.158V, ER IL-2\]

DRUG

Avelumab

Avelumab

DRUG

Bevacizumab

Bevacizumab

DRUG

Capecitabine

Capecitabine

DRUG

Cyclophosphamide

2-\[bis(2-chloroethyl)amino\]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate

DRUG

5-Fluorouracil

5-fluoro-2,4 (1H,3H)-pyrimidinedione

DRUG

Leucovorin

L-Glutamic acid, N-\[4-\[\[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl\]amino\]benzoyl\]-, calcium salt

DRUG

Oxaliplatin

Oxaliplatin

Trial Locations (1)

90245

Chan Soon-Shiong Institute for Medicine, El Segundo

Sponsors

Lead Sponsor

All Listed Sponsors
lead

ImmunityBio, Inc.

INDUSTRY

NCT03563144 - QUILT-3.088: NANT Pancreatic Cancer Vaccine | Biotech Hunter | Biotech Hunter