Study of Adagloxad Simolenin (OBI-822)/OBI-821 in the Adjuvant Treatment of Patients With Globo H Positive TNBC

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

575

Participants

Timeline

Start Date

December 5, 2018

Primary Completion Date

December 30, 2025

Study Completion Date

December 30, 2027

Conditions
Triple Negative Breast Cancer
Interventions
BIOLOGICAL

adagloxad simolenin combined with OBI-821

In the neoadjuvant and adjuvant phases of the study for a total of 100 weeks; subcutaneously injections.

DEVICE

Globo H IHC Assay

The Globo H IHC assay will be used to identify eligible patients who may clinically benefit from the OBI-822 treatment, defined by Globo H expression.

OTHER

Standard of care treatment

Standard of care treatment consisting of observation alone, adjuvant capecitabine or platinum monotherapy over a 100 week period.

Trial Locations (128)

100

National Taiwan University Hospital, Taipei

500

Changhua Christian Hospital, Changhua

704

National Cheng Kung University Hospital, Tainan City

807

Kaohsiung Medical University Chung-Ho Memorial Hospital, Kaohsiung City

2010

St Vincent's Hospital Sydney, Darlinghurst

2145

Westmead Hospital, Westmead

2193

Netcare Milpark Hospital, Johannesburg

Wits Clinical Research, a division of Wits Health Consortium (Pty) Ltd, Johannesburg

2196

Medical Oncology Centre of Rosebank, Johannesburg

2250

Gosford Hospital, Gosford

3002

Victoria Breast & Oncology Care, East Melbourne

3135

Eastern Health - Maroondah Hospital, Ringwood East

3144

Cabrini Malvern, Malvern

4655

Cancer Care Service, Hervey Bay Hospital, Urraween

6150

St John of God Murdoch Hospital, Murdoch

10002

CI Reg. Oncol. Dispanser, Zhytomyr

10408

National Cancer Center, Goyang-si

10507

Chang Gung Medical Foundation Linkou, Taipei

11217

Taipei Veterans General Hospital, Taipei

11259

Koo Foundation Sun Yat-Sen Cancer Center, Taipei

11490

Tri-Service General Hospital, Taipei

13620

Seoul National University Bundang Hospital, Seongnam-si

14080

Instituto Nacional de Cancerologia, Mexico City

14784

Hospital de Cancer de Barretos, Barretos

15038

Instituto Nacional de Enfermedades Neoplasicas, Lima

15072

Hospital Nacional Edgardo Rebagliati Martins, Unidad de Investigacion de Oncologia Medica, Lima

Unidad de Investigacion - Oncologia Medica Clinica San Felipe, Lima

15213

Magee-Womens Hospital of UPMC, Pittsburgh

15801

Hospital Maria Auxiliadora, Lima

16247

The Catholic University of Korea, St. Vincent's Hospital, Suwon

20010

Investigacion Biomedica para el Desarrollo de Farmacos, S.A. de. C.V, Aguascalientes

21201

University of Maryland Greenbaum Comprehensive Cancer Center, Baltimore

22332

Inha University Hospital, Incheon

23114

Bons Secours St. Francis Medical Oncology Center, Midlothian

25279

Clinica Oncor - Centro de Infusion e Investigacion Oncologia de Satillo, Saltillo

31000

Centro Estatal de Cancerologia, Chihuahua City

Icaro Investigaciones en Medicina S.A. de C.V., Chihuahua City

31207

Scientia Investigacion Clinica S.C., Chihuahua City

33176

Miami Cancer Institute, Miami

45070

Investigacion Biomedica para el Desarrollo de Farmacos, Zapopan

48202

Henry Ford Medical Center, Detroit

49044

Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine, Dnipro

49102

City Clinical Hospital #4, Dnipro

49201

Dong-A University Hospital, Busan

50180

Centro Oncologico Estatal Instituto de Seguridad Social del Estado de Mexico y Municipios, Toluca

58260

Sociedad Administradora de Servicios de Salud S.C., Morelia

60637

University of Chicago Medical, Chicago

60810

Suporte Nutricional e Quimioterapia, Fortaleza

61166

CI of Healthcare Regional Clinical Specialized Dispensary of the Radiation Protection, Kharkiv

66278

Centro Medico Zambrano Hellion, San Pedro Garza García

73000

CI of Kherson Reg Council Kherson Regional Oncologic Dispensary, Kherson

76018

CI Transcarpathian Cl Onc Center Dep of Surgery#1 SHEI Ivano-Frankivsk NMU, Ivano-Frankivsk

78229

University of Texas Health Science Center at San Antonio, San Antonio

92093

Moores UCSD Cancer Center, La Jolla

92120

Kaiser Permanente Medical Center, San Diego

94158

UCSF Helen Diller Family Comprehensive Cancer Centre, San Francisco

98405

Northwest Medical Specialties, PLLC, Tacoma

98700

Oncosite-Centro de Pesquisa Clinica em Oncologia, Ijuí

100021

Cancer Hospital Chinese Academy of Medical Sciences, Beijing

100024

Cancer Institute and Hospital, Beijing

100142

Beijing Cancer Hospital, Beijing

110001

Liaoning Cancer Hospital and Institute, Shenyang

110101

The First Hospital of China Medical University, Shenyang

115478

"FSBSI Russian Oncological Scientific Center n.a. N.N. Blokhin", Moscow

130021

The First Hospital of Jilin University, Changchun

143423

"SBIH of Moscow city Moscow city oncology hospital №62 of Moscow Healthcare department", Moscow

150054

"SBIH of Yaroslavl region Regional Clinical Oncological Hospital", Yaroslavl

150081

Harbin Medical University Cancer Hospital, Harbin

163045

"SBIH of Arkhangelsk region Arkhangelsk Clinical Oncological Dispensary", Arkhangelsk

194356

LLC Medaid, Saint Petersburg

197022

"SPb SBIH City Clinical Oncological Dispensary", Saint Petersburg

197110

Klinika Luch, Ltd., Saint Petersburg

197758

N.N. Petrov National Medical Research Center of Oncology, Pesochnyy

210036

Jiangsu Province Hospital, Nanjing

300060

Tianjin Cancer Hospital, Tianjin

310020

Sir Run Run Shaw Hospital, Hangzhou

310022

Zhejiang Cancer Hospital, Hangzhou

404133

"SBHI Volgograd Regional Oncology Dispensary #3", Volzhskiy

410008

Xiangya Hospital Central South University, Changsha

410013

Hunan Cancer Hospital, Changsha

430005

Nat. Research Mordovia State University, Saransk

430079

Hubei Cancer Hospital, Wuhan

460021

Orenburg Regional Clinical Oncological Center, Orenburg

510060

Sun Yat-Sen University Cancer Center, Guangzhou

530021

The First Affiliated Hospital of Guangxi Medical University, Nanning

610072

Sichuan Provincial People's Hospital, Chengdu

644013

"BHI of Omsk region Clinical Oncology Dispensary", Omsk

660133

Krasnoyarsk Territorial Clinical Oncology Center named after A.I. Kryzhanovsky, Krasnoyarsk

08903

Rutgers Cancer Institute of New Jersey, New Brunswick

Unknown

Breast Cancer Research Centre, Nedlands

Hospital de Clinicas de Porto Alegre, Barretos

Chung Shan Medical University Hospital, Taichung

29160-750

Centro de Avaliacao de Medicamentos e Especialidades de Pesquisa, Serra

41253-90

Hospital Sao Rafael, Salvador

30380-472

Instituto Mario Penna, Belo Horizonte

83606-177

Maternidade e Cirurgia Nossa Senhora do Rocio, Campo Largo

80060-900

Hospital das Clinicas - Universidade Federal do Parana, Curitiba

66073-005

Centro de Tratamento Oncologico LTDA - CTO, Belém

52010-000

Hospital do Capibaribe, Recife

52010-075

Real Hospital Portugues de Beneficencia de Pernambuco, Recife

64049-200

Centro de Pesquisa Vencer & Oncolinca, Teresina

96040-010

Hospital Escola da Universidade Federal de Pelotas, Pelotas

90050-170

Irmandade da Santa Casa de Misericordia de Porto Alegre, Porto Alegre

90610-000

Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) - Hospital Sao Lucas, Porto Alegre

76834-899

Hospital de Amor Amazonia, Porto Velho

69304-015

Centro Oncologico de Roraima, Boa Vista

89801-355

Clinica Supera, Chapecó

88300-000

Clinica de Neoplasias Litoral - Itajai, Itajaí

17210-120

Hospital Amaral Carvalho de Jau, Jaú

09060

Centro de Pesquisa Clinica em Hematologia e Oncologia, Santo André

01317-001

Clinicia de Pesquisa e Centro de Estudos em Oncologia Ginecologica e Mamaria, São Paulo

04014

Instituto Brasileiro de Controle do Cancer, São Paulo

05403-900

Instituto do Cancer do Estado de San Paulo, São Paulo

00000

Queen Mary Hospital, Hong Kong

04002

Instituto Regional de Enfermedades Neoplasicas del Sur, Arequipa

80-214

University Clinical Centre - Hospital, Teaching Dept of Oncology and Radiotherapy, Gdansk

30-688

Independent Public Healthcare Facility University Hospital in Cracow, Krakow

90-242

Contemporary Therapy Centre, Lodz

93-338

Polish Mother's Memorial Hospital Research Instistute, Lodz

02-507

Central Teaching Hospital of the MOI in Warsaw, Warsaw

02-781

Maria Sklodowska-Curie National Institute of Oncology, Warsaw

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06591

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

120-752

Severance Hospital, Yonsei University Health System, Seoul

03002

Medical Center of Vision Partner, Kyiv

03039

Medical Center Verum, Kyiv

03115

Kyiv Сity Clinical Oncological Center, Kyiv

Sponsors

Lead Sponsor

All Listed Sponsors
lead

OBI Pharma, Inc

INDUSTRY