97
Participants
Start Date
December 1, 2017
Primary Completion Date
December 31, 2019
Study Completion Date
January 31, 2020
Group A (the standard 2HRZE/4HR regimen）
The standard six-month regimen is eight weeks of daily treatment with isoniazid, rifampin, ethambutol, and pyrazinamide followed by sixteen weeks of isoniazid and rifampin. The six-month regimen is the standard regimen for the treatment of drug-susceptible tuberculosis recommended by WHO.
Group B (New short course PRS regimen, 4EZ(high dose)PtoCfz)
The PRS regimen I（new short course PRS regimen） is 4 months of daily Cfz, Emb, Pto, and high dose pyrazinamide, dosed by weight.Comparison of Standard Regimen：The standard six-month regimen is eight weeks of daily treatment with isoniazid, rifampin, ethambutol, and pyrazinamide followed by sixteen weeks of isoniazid and rifampin.
Eighty-fifth Hospital of PLA, Shanghai
Shanghai Public Health Clinical Center Shanghai, China, Shanghai
Shanghai Center for Disease Control and Prevention, Shanghai
Shanghai Pulmonary Hospital, Shanghai, China, Shanghai
Shanghai Center for Disease Control and Prevention
OTHER
No.85 Hospital, Changning, Shanghai, China
OTHER
Shanghai Public Health Clinical Center
OTHER_GOV
Bill and Melinda Gates Foundation
OTHER
University of California, Los Angeles
OTHER
Shanghai Pulmonary Hospital, Shanghai, China
OTHER