Universal Prophylaxis Versus Pre-emptive Therapy With Posaconazole Post-Lung Transplant

PHASE2UnknownINTERVENTIONAL
Enrollment

140

Participants

Timeline

Start Date

July 2, 2018

Primary Completion Date

September 30, 2020

Study Completion Date

September 30, 2020

Conditions
Fungal Infection
Interventions
OTHER

Universal Posaconazole Prophylaxis

All patients assigned to this arm will start posaconazole between Day 4 and Day 14 post lung or heart-lung transplant for a minimum of 3 months.

OTHER

Pre-emptive Posaconazole Therapy

Posaconazole will be started if a fungal pathogen is identified or there is serological evidence of a fungal pathogen in the absence of any evidence of invasive fungal disease for 3 months.

Trial Locations (3)

2010

St. Vincent's Hospital, Sydney

3004

Alfred Health, Melbourne

4032

The Prince Charles Hospital, Brisbane

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Bayside Health

OTHER_GOV