3,000
Participants
Start Date
July 5, 2018
Primary Completion Date
February 15, 2026
Study Completion Date
April 1, 2026
Standard of Care IMRT (Photon)
As this trial is pragmatic, all treatment will be standard of care.
Standard of Care Proton Therapy
As this trial is pragmatic, all treatment will be standard of care.
Proton Arm 1: Standard Proton Therapy
78.0 Gy (RBE) in 39 fractions
Proton Arm 2: Hypofractionated Proton Therapy
60.0 Gy (RBE) in 20 fractions
New York Proton Center, New York
Weill Cornell, New York
University of Pennsylvania--Penn Medicine, Philadelphia
Thomas Jefferson University, Philadelphia
University of Maryland, College Park
Johns Hopkins University, Baltimore
Inova Schar Cancer Institute, Fairfax
University of Virginia, Charlottesville
Hampton University Proton Therapy Institute, Hampton
UNC- Rex Hospital, Raleigh
The Duke University Health System, Durham
Medical University of South Carolina, Charleston
Winship Cancer Institute - Emory University, Atlanta
University of Florida Proton Therapy Institute, Jacksonville
Ackerman Cancer Center, Jacksonville
Mayo Clinic, Jacksonville
Department of Radiation Oncology Davis Cancer Pavilion, Gainesville
Orlando Health UF Health Center, Orlando
University of Miami School of Medicine, Miami
Miami Cancer Institute, Miami
University of Alabama at Birmingham (UAB), Birmingham
Provision CARES Proton Therapy Center Knoxville, Knoxville
University of Louisville, Louisville
Cleveland Clinic, Cleveland
University Hospitals- Seidman Cancer Center, Cleveland
University of Cincinnati Medical PTC, Cincinnati
Karmanos Cancer Institute, Detroit
Mayo Clinic Health System-Franciscan Healthcare, Sparta
Mayo Clinic Health System, Eau Claire
Mayo Clinic, Rochester
Mayo Clinic Health System, Mankato
Northwestern Medicine Proton Center, Warrenville
University of Chicago, Chicago
S Lee Kling Proton Therapy Center - Washington University Medical Center, St Louis
University of Kansas Medical Center, Lawrence
Willis-Knighton Medical Center PTC, Shreveport
Stephenson Cancer Center, Oklahoma City
Texas Center for Proton Therapy, Irving
Texas Oncology - McKinney, McKinney
Texas Oncology - Plano West, Plano
Texas Oncology - Longview, Longview
Texas Oncology - Waco, Waco
University of Texas MD Anderson Cancer Center, Houston
Texas Oncology, Austin
University of California San Diego, La Jolla
California Protons Cancer Therapy Center, San Diego
Proton Therapy Treatment Center - Loma Linda University, Loma Linda
Sutter Health, Roseville
Oregon Health & Science University, Portland
Seattle Care Alliance/University of Washington, Seattle
Massachusetts General Hospital, Boston
Rutgers Cancer Institute of New Jersey, New Brunswick
Covenant Health, Somerset
Patient-Centered Outcomes Research Institute
OTHER
University of Florida
OTHER