52
Participants
Start Date
June 27, 2018
Primary Completion Date
June 14, 2022
Study Completion Date
November 22, 2022
ANI-REMI-loop
experimental medical device using expert rules and continuous reading of heart rate, blood pressure and Analgesia Nociception Index for automatic remifentanil administration
remifentanil pK/pD target administration device
standard practice, remifentanil administration using Minto's pK/pD model
Remifentanil
Remifentanil Ce target can range from 0 to 10 ng.ml-1. Remifentanil target is adapted in order to maintain Analgesia Nociception Index (MDMS, Loos, France) in the \[50-70\] range.
Propofol
propofol is used for induction and maintenance of general anesthesia using Schnider pK/pD model. Propofol Ce target is adapted in order to maintain BiSpectral Index in \[40-60\] range
ANI monitor
"ANI (Analgesia Nociception Index) value is used in the std\_practice arm for guidance of the remifentanil Ce target"
Hôpital Roger Salengro, CHU, Lille
University Hospital, Lille
OTHER