Dual Antiplatelet Therapy For Shock Patients With Acute Myocardial Infarction

PHASE4CompletedINTERVENTIONAL
Enrollment

605

Participants

Timeline

Start Date

August 1, 2018

Primary Completion Date

February 19, 2024

Study Completion Date

April 1, 2025

Conditions
Acute Myocardial InfarctionCardiogenic Shock
Interventions
DRUG

Cangrelor

"Cangrelor: IV bolus 30 µg/kg (application \< 1 minute) followed immediately by continuous infusion at 4 µg/kg. Tables to calculate bolus dose in ml and infusion (in ml per hour) rate for each body weight group will be prepared in advance and will be included in the study medication kit to accelerate treatment start.~* Cangrelor treatment will be discontinued after circulatory stabilization (but no earlier than 2 hours after infusion initiation) i.e. after systolic Blood Pressure (sBP) is maintained at the level \> 100 mmHg for one hour after the end of IABK and/or vasoactive treatment is discontinued, but no later than 4 hours after PCI,~* 30 minutes before the end of Cangrelor infusion, administration of Ticagrelor 180 mg (crushed tablets) and then dose 90 mg every 12 hours."

DRUG

Ticagrelor

Ticagrelor: 180 mg loading dose - crushed tablets, 2 x 90 mg maintenance dose

Trial Locations (29)

10034

University Hospital Kralovske Vinohrady, Prague

12808

General University Hospital in Prague, Prague

14021

Institute of Clinical and Experimental Medicine, Prague

40011

Masaryk Hospital, Ústí nad Labem

70852

University Hospital Ostrava, Ostrava

72076

University Hospital Tübingen, Tübingen

77900

University Hospital Olomouc, Olomouc

656 91

St. Anne's University Hospital Brno, Brno

Unknown

Department of Cardiology, University Hospital Brno-Bohunice, Brno

Cardiology Department, Regional Hospital, České Budějovice

Cardiology department, Regional hospital, Jihlava

Cardiocenter, Regional Hospital, Karlovy Vary

Department of Cardiology, Regional Hospital,, Pardubice

Cardiocenter, Hospital Podlesi, Třinec

Département de Cardiologie, Hôpital Bichat Assistance Publique Hôpitaux de Paris, Paris

Pitié-Salpêtrière Hospital (AP-HP), Paris

Heart Center Freiburg University, Freiburg im Breisgau

University Medical Centre, Mannheim

Collegium Medicum University Hospital No. 1, Bydgoszcz

Jagiellonianan University, University Hospital Krakow, Krakow

Medical University of Warsaw, Warsaw

Middle-Slovak Institute of Cardiovascular Diseases, Banská Bystrica

Center of Interventional Neuroradiology and Endovascular Treatment, Bratislava

Cardiocentre, Nitra

500 05

University Hospital Hradec Králové, Hradec Králové

460 63

Krajská nemocnice Liberec, Liberec

304 60

University Hospital Pilsen, Pilsen

150 30

Na Homolce Hospital, Prague

762 75

Regional Hospital T. Bati, Zlín

All Listed Sponsors
collaborator

Charles University, Czech Republic

OTHER

collaborator

Masaryk University

OTHER

collaborator

Ministry of Health, Czech Republic

OTHER_GOV

collaborator

National Institute for Metabolic and Cardiovascular Disease Research

UNKNOWN

collaborator

Institute of Hematology and Blood Transfusion, Czech Republic

OTHER

collaborator

BioVendor LM

UNKNOWN

lead

Faculty Hospital Kralovske Vinohrady

OTHER_GOV

NCT03551964 - Dual Antiplatelet Therapy For Shock Patients With Acute Myocardial Infarction | Biotech Hunter | Biotech Hunter