Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

PHASE3RecruitingINTERVENTIONAL
Enrollment

206

Participants

Timeline

Start Date

November 22, 2018

Primary Completion Date

June 30, 2027

Study Completion Date

December 31, 2027

Conditions
Brain Metastases
Interventions
DRUG

Memantine

20 mg (10 mg divided twice daily). Dose will be escalated by 5 mg per week. Memantine should start at 5 mg, and then increased in 5 mg increments at the following schedule, depending on the patient's response and tolerance:

RADIATION

Hippocampal-avoidant (HA-WBRT) Radiotherapy

30Gy in 10 fractions

PROCEDURE

Stereotactic Radiosurgery (SRS)

18-20 or 22 Gy in single fraction

Trial Locations (86)

13210

SUSPENDED

State University of New York Upstate Medical University, Syracuse

13215

SUSPENDED

SUNY Upstate Medical Center-Community Campus, Syracuse

17822

RECRUITING

Geisinger Medical Center, Danville

18711

RECRUITING

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

18925

ACTIVE_NOT_RECRUITING

Fox Chase Cancer Center Buckingham, Furlong

19111

ACTIVE_NOT_RECRUITING

Fox Chase Cancer Center, Philadelphia

21401

ACTIVE_NOT_RECRUITING

Luminis Health Anne Arundel Medical Center, Annapolis

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27403

RECRUITING

Cone Health Cancer Center, Greensboro

27834

ACTIVE_NOT_RECRUITING

East Carolina University, Greenville

28801

ACTIVE_NOT_RECRUITING

Mission Hospital, Asheville

29646

ACTIVE_NOT_RECRUITING

Self Regional Healthcare, Greenwood

30309

ACTIVE_NOT_RECRUITING

Piedmont Hospital, Atlanta

30322

SUSPENDED

Emory University Hospital/Winship Cancer Institute, Atlanta

30342

SUSPENDED

Emory Saint Joseph's Hospital, Atlanta

33021

ACTIVE_NOT_RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33028

ACTIVE_NOT_RECRUITING

Memorial Hospital West, Pembroke Pines

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

33486

ACTIVE_NOT_RECRUITING

Boca Raton Regional Hospital, Boca Raton

33612

ACTIVE_NOT_RECRUITING

Moffitt Cancer Center, Tampa

46256

ACTIVE_NOT_RECRUITING

Community Cancer Center North, Indianapolis

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

55101

RECRUITING

Regions Hospital, Saint Paul

55905

ACTIVE_NOT_RECRUITING

Mayo Clinic in Rochester, Rochester

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

59101

SUSPENDED

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

60153

RECRUITING

Loyola University Medical Center, Maywood

60555

ACTIVE_NOT_RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

ACTIVE_NOT_RECRUITING

Northwestern University, Chicago

61636

RECRUITING

Methodist Medical Center of Illinois, Peoria

61637

RECRUITING

OSF Saint Francis Medical Center, Peoria

61801

RECRUITING

Carle Cancer Center, Urbana

62269

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

62526

RECRUITING

Decatur Memorial Hospital, Decatur

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

73104

ACTIVE_NOT_RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

83706

SUSPENDED

Saint Alphonsus Cancer Care Center-Boise, Boise

84112

SUSPENDED

Huntsman Cancer Institute/University of Utah, Salt Lake City

85704

RECRUITING

University of Arizona Cancer Center-Orange Grove Campus, Tucson

85719

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

90503

RECRUITING

City of Hope South Bay, Torrance

91010

RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

91030

RECRUITING

City of Hope South Pasadena, South Pasadena

91786

RECRUITING

City of Hope Upland, Upland

92093

SUSPENDED

UC San Diego Moores Cancer Center, La Jolla

92618

RECRUITING

City of Hope at Irvine Lennar, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

92882

RECRUITING

City of Hope Corona, Corona

93534

RECRUITING

City of Hope Antelope Valley, Lancaster

94080

ACTIVE_NOT_RECRUITING

Kaiser Permanente Cancer Treatment Center, South San Francisco

94928

ACTIVE_NOT_RECRUITING

Rohnert Park Cancer Center, Rohnert Park

95051

ACTIVE_NOT_RECRUITING

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95670

ACTIVE_NOT_RECRUITING

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova

95678

ACTIVE_NOT_RECRUITING

The Permanente Medical Group-Roseville Radiation Oncology, Roseville

95823

ACTIVE_NOT_RECRUITING

South Sacramento Cancer Center, Sacramento

97210

RECRUITING

Legacy Good Samaritan Hospital and Medical Center, Portland

32224-9980

ACTIVE_NOT_RECRUITING

Mayo Clinic in Florida, Jacksonville

20889-5600

RECRUITING

Walter Reed National Military Medical Center, Bethesda

02111

RECRUITING

Tufts Medical Center, Boston

03756

ACTIVE_NOT_RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

08234

RECRUITING

AtlantiCare Surgery Center, Egg Harbor

05819

ACTIVE_NOT_RECRUITING

Dartmouth Cancer Center - North, Saint Johnsbury

T2N 5G2

RECRUITING

Arthur J E Child Comprehensive Cancer Centre, Calgary

T6G 1Z2

RECRUITING

Cross Cancer Institute, Edmonton

V5Z 4E6

RECRUITING

BCCA-Vancouver Cancer Centre, Vancouver

B3H 2Y9

RECRUITING

QEII Health Sciences Centre/Nova Scotia Health Authority, Halifax

L8V 5C2

RECRUITING

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

N6A 4L6

RECRUITING

London Regional Cancer Program, London

M5G 2M9

RECRUITING

University Health Network-Princess Margaret Hospital, Toronto

J4V 2H1

SUSPENDED

CSSS Champlain-Charles Le Moyne, Greenfield Park

H2X 3E4

RECRUITING

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal

H3H 2R9

SUSPENDED

The Research Institute of the McGill University Health Centre (MUHC), Montreal

H3T 1E2

RECRUITING

Jewish General Hospital, Montreal

G1R 2J6

RECRUITING

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Québec

J1H 5N4

SUSPENDED

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Alliance for Clinical Trials in Oncology

OTHER

collaborator

NRG Oncology

OTHER

lead

Canadian Cancer Trials Group

NETWORK