NCT03548935 - STEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | Biotech Hunter

Enrollment

1,961

Participants

Timeline

Start Date

June 4, 2018

Primary Completion Date

March 30, 2020

Study Completion Date

March 5, 2021

Conditions

Metabolism and Nutrition DisorderOverweight or Obesity

Interventions

DRUG

Semaglutide

Participants will receive semaglutide subcutaneous (s.c.; under the skin) injection(s) once-weekly as well as diet and physical activity counselling for 68 weeks. Dose escalation of semaglutide will take place as follows: 0.25 mg from week 1 to 4, 0.5 mg from week 5 to 8, 1.0 mg from week 9 to 12, 1.7 mg from week 13 to 16 and 2.4 mg from week 17 to week 68.

DRUG

Placebo (semaglutide)

Participants will receive semaglutide matching placebo s.c. injection(s) once-weekly as well as diet and physical activity counselling for 68 weeks.

Trial Locations (128)

100

Novo Nordisk Investigational Site, Taipei

1200

Novo Nordisk Investigational Site, Brussels

1431

Novo Nordisk Investigational Site, Sofia

1606

Novo Nordisk Investigational Site, Sofia

1797

Novo Nordisk Investigational Site, Sofia

2650

Novo Nordisk Investigational Site, Edegem

3000

Novo Nordisk Investigational Site, Leuven

3400

Novo Nordisk Investigational Site, Corrientes

4000

Novo Nordisk Investigational Site, Liège

4002

Novo Nordisk Investigational Site, Plovdiv

6300

Novo Nordisk Investigational Site, Santa Rosa

7300

Novo Nordisk Investigational Site, Boussu

8200

Novo Nordisk Investigational Site, Aarhus N

11108

Novo Nordisk Investigational Site, Narbonne

12627

Novo Nordisk Investigational Site, Berlin

14609

Novo Nordisk Investigational Site, Rochester

14612

Novo Nordisk Investigational Site, Falkensee

19611

Novo Nordisk Investigational Site, West Reading

22607

Novo Nordisk Investigational Site, Hamburg

23294

Novo Nordisk Investigational Site, Richmond

28144

Novo Nordisk Investigational Site, Salisbury

28401

Novo Nordisk Investigational Site, Wilmington

28630

Novo Nordisk Investigational Site, Le Coudray

29425

Novo Nordisk Investigational Site, Charleston

29681

Novo Nordisk Investigational Site, Simpsonville

30076

Novo Nordisk Investigational Site, Roswell

32081

Novo Nordisk Investigational Site, Ponte Vedra

32205

Novo Nordisk Investigational Site, Jacksonville

32216

Novo Nordisk Investigational Site, Jacksonville

32401

Novo Nordisk Investigational Site, Panama City

32626

Novo Nordisk Investigational Site, Chiefland

33324

Novo Nordisk Investigational Site, Plantation

33600

Novo Nordisk Investigational Site, Pessac

34429

Novo Nordisk Investigational Site, Crystal River

34470

Novo Nordisk Investigational Site, Ocala

35392

Novo Nordisk Investigational Site, Giessen

36207

Novo Nordisk Investigational Site, Anniston

40213

Novo Nordisk Investigational Site, Louisville

44670

Novo Nordisk Investigational Site, Guadalajara

44787

Novo Nordisk Investigational Site, Bochum

45136

Novo Nordisk Investigational Site, Essen

45219

Novo Nordisk Investigational Site, Essen

46260

Novo Nordisk Investigational Site, Indianapolis

49620

Novo Nordisk Investigational Site, Buckley

59701

Novo Nordisk Investigational Site, Butte

60313

Novo Nordisk Investigational Site, Frankfurt

60607

Novo Nordisk Investigational Site, Chicago

60611

Novo Nordisk Investigational Site, Chicago

63303

Novo Nordisk Investigational Site, City of Saint Peters

66386

Novo Nordisk Investigational Site, Saint Ingbert-Oberwürzbach

66606

Novo Nordisk Investigational Site, Topeka

68105

Novo Nordisk Investigational Site, Omaha

69200

Novo Nordisk Investigational Site, Vénissieux

69310

Novo Nordisk Investigational Site, Pierre-Bénite

70378

Novo Nordisk Investigational Site, Stuttgart

75226

Novo Nordisk Investigational Site, Dallas

75230

Novo Nordisk Investigational Site, Dallas

75234

Novo Nordisk Investigational Site, Dallas

75651

Novo Nordisk Investigational Site, Paris

75908

Novo Nordisk Investigational Site, Paris

78681

Novo Nordisk Investigational Site, Round Rock

78749

Novo Nordisk Investigational Site, Austin

80045

Novo Nordisk Investigational Site, Aurora

83280

Novo Nordisk Investigational Site, Hermosillo

84010

Novo Nordisk Investigational Site, Bountiful

88239

Novo Nordisk Investigational Site, Wangen

90220

Novo Nordisk Investigational Site, Oulu

90717

Novo Nordisk Investigational Site, Lomita

91978

Novo Nordisk Investigational Site, Spring Valley

92801

Novo Nordisk Investigational Site, Anaheim

97070

Novo Nordisk Investigational Site, Mérida

98057

Novo Nordisk Investigational Site, Renton

110029

Novo Nordisk Investigational Site, New Dehli

117036

Novo Nordisk Investigational Site, Moscow

124001

Novo Nordisk Investigational Site, Rohtak

141001

Novo Nordisk Investigational Site, Ludhiana

150003

Novo Nordisk Investigational Site, Yaroslavl

194358

Novo Nordisk Investigational Site, Saint Petersburg

394018

Novo Nordisk Investigational Site, Voronezh

395002

Novo Nordisk Investigational Site, Surat

411004

Novo Nordisk Investigational Site, Pune

411021

Novo Nordisk Investigational Site, Pune

440003

Novo Nordisk Investigational Site, Nagpur

440026

Novo Nordisk Investigational Site, Penza

500003

Novo Nordisk Investigational Site, Secunderabad,

522001

Novo Nordisk Investigational Site, Guntur

600116

Novo Nordisk Investigational Site, Chennai

630099

Novo Nordisk Investigational Site, Novosibirsk

630117

Novo Nordisk Investigational Site, Novosibirsk

634041

Novo Nordisk Investigational Site, Tomsk

695031

Novo Nordisk Investigational Site, Thiruvananthapuram

700054

Novo Nordisk Investigational Site, Kolkata

06708

Novo Nordisk Investigational Site, Waterbury

37212-1150

Novo Nordisk Investigational Site, Nashville

C1093AAS

Novo Nordisk Investigational Site, CABA

C1204AAD

Novo Nordisk Investigational Site, Ciudad de Buenos Aires

X5006IKK

Novo Nordisk Investigational Site, Córdoba

T6H 2L4

Novo Nordisk Investigational Site, Edmonton

V3Z 2N6

Novo Nordisk Investigational Site, Surrey

L8L 5G8

Novo Nordisk Investigational Site, Hamilton

M2M 4J5

Novo Nordisk Investigational Site, North York

M4P 1P2

Novo Nordisk Investigational Site, Toronto

G1V 4G2

Novo Nordisk Investigational Site, Québec

G1V 4G5

Novo Nordisk Investigational Site, Québec

00014

Novo Nordisk Investigational Site, University of Helsinki

06679

Novo Nordisk Investigational Site, Hohenmölsen

04103

Novo Nordisk Investigational Site, Leipzig

500 012

Novo Nordisk Investigational Site, Hyderabad

260-8677

Novo Nordisk Investigational Site, Chiba-shi, Chiba

565-0853

Novo Nordisk Investigational Site, Suita-shi, Osaka

103-0027

Novo Nordisk Investigational Site, Tokyo

103-0028

Novo Nordisk Investigational Site, Tokyo

160-0008

Novo Nordisk Investigational Site, Tokyo

81-338

Novo Nordisk Investigational Site, Gdynia

90-242

Novo Nordisk Investigational Site, Lodz

60-589

Novo Nordisk Investigational Site, Poznan

70-376

Novo Nordisk Investigational Site, Szczecin

00921

Novo Nordisk Investigational Site, San Juan

BS10 5NB

Novo Nordisk Investigational Site, Bristol

CB2 0QQ

Novo Nordisk Investigational Site, Cambridge

CV2 2DX

Novo Nordisk Investigational Site, Coventry

G31 2ER

Novo Nordisk Investigational Site, Glasgow

L9 7AL

Novo Nordisk Investigational Site, Liverpool

SE1 9RT

Novo Nordisk Investigational Site, London

W1T 7HA

Novo Nordisk Investigational Site, London

NR4 7UQ

Novo Nordisk Investigational Site, Norwich

S65 1DA

Novo Nordisk Investigational Site, Rotherham

TA1 5DA

Novo Nordisk Investigational Site, Taunton