789
Participants
Start Date
June 15, 2018
Primary Completion Date
October 15, 2019
Study Completion Date
November 4, 2019
Vericiguat (BAY1021189) 2.5 mg, 5 mg or 10 mg IR tablets
Oral use. Vericiguat, which will be started at 2.5 mg at randomization and up-titrated to 5 mg at week 2, and to 10 mg at week 4, with sham titration or up-titration to 15 mg at week 6.
Placebo
Placebo and sham up-titration at weeks 2, 4, and 6
Caja de Compensación Familiar CAFAM, Bogotá
Cheng Hsin General Hospital, Taipei
Far Eastern Memorial Hospital, New Taipei City
Budai Irgalmasrendi Korhaz, Budapest
Zentrum f. klinische Studien Dr. Hanusch GmbH, Vienna
Universitätsklinikum AKH Wien, Vienna
Magyar Honvedseg Egeszsegugyi Kozpont Honvedkorhaz, Budapest
Second Medical Center Sofia EOOD, Sofia
Klinik Floridsdorf - Krankenhaus Nord, Vienna
NMTH Tzar Boris III, Sofia
V MHAT, Sofia
Spec Hosp for Active Treatm in Cardiology Sv Georgi Pernik, Pernik
H. Hartziekenhuis Mol, Mol
UZ Antwerpen, Edegem
Universitätsklinikum St. Pölten, Sankt Pölten
Pharma4Trial Kft., Gyöngyös
Inst. de Cardiología de Corrientes Juana Francisca Cabral, Corrientes
Multiprofile Hospital for Active Treatment Medline Clinic, Plovdiv
Ordensklinikum Linz GmbH Elisabethinen, Linz
Nash Ranjith Research Centre, Merebank
Durban Medical Centre, Durban
Multiprofile Hospital for Active Treatment Pazardzhik, Pazardzhik
Medifarma-98 Egeszsegugyi, Kereskedelmi es Szolgaltato Kft., Nyíregyháza
MHAT Dr. Bratan Shukerov AD, Smolyan
Krankenhaus St. Josef Braunau, Braunau am Inn
Specialized Hospital for Actrive Treatm of Card - Pleven, Pleven
Vergelegen Medi-Clinic, Somerset West
TREAD Research cc, Cape Town
Tiervlei Trial Centre, Cape Town
AZ St-Jan Brugge Oostende AV, Bruges
Medizinische Universität Graz, Graz
AZ Delta, Roeselare
Kanizsai Dorottya Hospital, Nagykanizsa
MHAT Sveta Marina EAD, Varna
Algemeen Stedelijk Ziekenhuis Campus Aalst, Aalst
National Taiwan University Hospital, Taipei
Taipei Veterans General Hospital, Taipei
G. GENNIMATAS General State Hospital of Athens, Athens
KAT General Hospital of Athens, Kifisia / Athens
Hospital Raja Perempuan Zainab II, Kelantan
Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela
Capital Area Research, LLC, Camp Hill
IRCCS Istituto Clinico Humanitas - Humanitas Mirasole S.p.A., Milan
ASST Grande Ospedale Metropolitano Niguarda, Milan
Anne Arundel Health System, Annapolis
Cardiologicum Hamburg - Praxen Wandsbek, Hamburg
Corporation Lane Research Center, Virginia Beach
ASST Papa Giovanni XXIII, Bergamo
ASST Spedali Civili di Brescia, Brescia
IRCCS Fondazione Policlinico San Matteo, Pavia
Wake Forest Baptist Health, Winston-Salem
Hospital Sanitas La Zarzuela, Aravaca
Hospital Universitario Clinica Puerta de Hierro, Majadahonda
Hospital Virgen de la Victoria, Málaga
Carolina Heart Specialists, Lancaster
East Coast Institute for Research, LLC, Saint Augustine
Cardiology Associates Research Company, Daytona Beach
Herz- und Diabeteszentrum Nordrhein-Westfalen (HDZ NRW), Bad Oeynhausen
LifeSpring Research Foundation, LLC, Miami
Cardiology Partners, Wellington
Cardiology Associates Of South Florida PA, Boynton Beach
Southwest Florida Research, Naples
Cardiovascular and Vein Center of Florida, Bradenton
Hospital Álvaro Cunqueiro, Babio - Beade
Stern Cardiovascular Center, Germantown
Riser Medical Associates, Picayune
A.O.U. di Bologna Policlinico S.Orsola Malpighi, Bologna
Complejo Hospitalario Ntra. Sra. de Valme, Seville
Kliniken Maria Hilf GmbH, Mönchengladbach
University General Hospital of Larissa, Larissa
Research Integrity, LLC, Owensboro
A.O.U. di Ferrara, Ferrara
Reid Health, Richmond
Henry Ford Health System, Detroit
Institute Jantung Negara, Kuala Lumpur
"AHEPA University General Hospital of Thessaloniki", Thessaloniki
Hippokration General Hospital of Thessaloniki, Thessaloniki
St. Vincenz und Elisabeth Hospital, Kathol. Klinikum Mainz, Mainz
Glacier View Research Institute, Kalispell
Advocate Condell Medical Center, Libertyville
Fox Valley Clinical Research Center, LLC, Aurora
St. Louis Heart & Vascular, PC, St Louis
Bryan Heart, Lincoln
Heart Clinic of Hammond, Hammond
Penrose-St. Francis Health Services, Colorado Springs
WestSide Medical, Beverly Hills
Interventional Cardiology Medical Group, West Hills
Sarawak Heart Centre, Sarawak
Capitol Interventional Cardiology, Carmichael
Klinikum der Universität Würzburg, Würzburg
Research center of therapy and prophylactic medicine, Moscow
Moscow State University n.a. M.V. Lomonosov, Moscow
Singapore General Hospital, Singapore
National Heart Centre Singapore, Singapore
City hospital #15, Saint Petersburg
City Pokrovskaya Hospital, Saint Petersburg
Samara Regional Clinical Cardiology Dispensary n.a. Polyakov, Samara
Sci-Res. Institute of Complex Cardiovascular Disorders, Kemerovo
Health Corporation of the Ziv Medical Center (R.A.), Safed
The Baruch Padeh Medical Center, Poria, Tiberias
HaEmek Medical Center, Afula
Rambam Health Corporation, Haifa
Hillel Yaffe Medical Center, Hadera
Chaim Sheba Medical Center, Ramat Gan
Shamir Medical Center (Assaf Harofeh), Zrifin
Kaplan Medical Center, Rehovot
Hadassah Hebrew University Hospital Ein Kerem, Jerusalem
Cardiology Associates of Fairfield County, PC, Trumbull
Clinical Advancement Center, PLLC, San Antonio
Clínica DIM, Ramos Mejía
Instituto de Investigaciones Clínicas San Nicolás, San Nicolás de los Arroyos
Centro de Investigaciones Clínicas, Buenos Aires
Centro de Medicina Integral e Investigacion Clínica, CABA
Centro de Especialidades Médicas, Villa Luro
Sanatorio Parque S.A., Rosario
Centro de Investigaciones Clinicas del Litoral, Santa Fe
University of Alberta, Edmonton
SMH Cardiology Clinical Trials Inc, Surrey
Cardiovascular CRO Ltd., Greater Sudbury
London Health Sciences Centre, London
PACE Cardiology Clinic, Newmarket
Oakville Cardiologists, Inc., Oakville
St. Michael's Hospital Health Centre, Toronto
Clinique Sante Cardio MC, Montreal
Centre De Recherche Du (CRCHUM) - Hotel-Diu, Montreal
CardioVasc HR, Inc., Saint-Jean-sur-Richelieu
Hospital General de Medellin, Medellín
IPS Centro Cientifico Asistencial S.A.S, Barranquilla
Mediservis del Tolima IPS S.A.S, Ibagué
Fundación Cardiovascular de Colombia, Floridablanca
Magyar Honvedseg Egeszsegugyi Kozpont Honvedkorhaz, Budapest
Clinical Trial Systems, Pretoria
Zentrum für Klinische Studien Südbrandenburg GmbH, Elsterwerda
Klinische Forschung Dresden GmbH, Dresden
Konstantopoulio General Hospital of Nea Ionia - AGIA OLGA, Nea Ionia / Athens
Asl Roma 6, Rome
A.O.U. di Sassari, Sassari
Seikeikai New Tokyo Heart Clinic, Matsudo
Steel Memorial Yawata Hospital, Kitakyushu
Matsuda Cardiovascular clinic, Sapporo
National Hospital Organization Kobe Medical Center, Kobe
Higashi Takarazuka Satoh Hospital, Takarazuka
National Hospital Organization Kanazawa Medical Center, Kanazawa
Iwate Prefectural Central Hospital, Morioka
Uji-Tokushukai Medical Center, Uji
Hirakata kohsai Hospital, Hirakata
Kishiwada Tokushukai Hospital, Kishiwada
Takatsuki Red Cross Hospital, Takatsuki
Osaka Medical College Hospital, Takatsuki
National Hospital Organization Hamada Medical Center, Hamada
Minamino Cardiovascular Hospital, Hachiōji
Toho University Omori Medical Center, Ōta-ku
Tokyo Women's Medical University Hospital, Shinjuku-ku
National Hospital Organization Iwakuni Clinical Center, Iwakuni
Fukui Prefectural Hospital, Fukui
Okayama Rosai Hospital, Okayama
Osaka General Medical Center, Osaka
Toyama Prefectural Central Hospital, Toyama
Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok
10 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ, Bydgoszcz
CLINICAL MEDICAL RESEARCH Sp. z o. o., Katowice
SPZOZ Centralny Szpital Kliniczny UM w Lodzi, Lodz
Szpital Kliniczny Przemienienia Panskiego, Poznan
Twoja Przychodnia - Szczecinskie Centrum Medyczne, Szczecin
Uniwersyteckie Centrum Kliniczne Warszawskiego UM, Warsaw
IV Wojskowy Szpital Kliniczny z Poliklinika, SPZOZ, Wroclaw
Dolnoslaski Szp. Spec. im T.M. Centrum Medycyny Ratunkowej, Wroclaw
Hospital de Cascais, Alcabideche
CHTS - Hospital Padre Americo, Guilhufe
CHS - Hospital Sao Bernardo, Setúbal
Hospital Garcia de Orta, Almada
CHLO - Hospital Sao Francisco Xavier, Lisbon
Hospital da Luz - Lisboa, Lisbon
CHUP - Hospital Santo Antonio, Porto
Ciutat Sanitària i Universitària de Bellvitge, L'Hospitalet de Llobregat
Hospital Sant Joan Despi Moises Broggi, Sant Joan Despí
Hospital del Mar, Barcelona
Lead Sponsor
Collaborators (1)
Merck Sharp & Dohme LLC
INDUSTRY
Canadian VIGOUR Centre
OTHER
Duke Clinical Research Institute
OTHER
Bayer
INDUSTRY