Study of rhPro-UK in Patients With Acute Ischaemic Stroke in 4.5 Hours After Stroke Onset(PROST)

PHASE3CompletedINTERVENTIONAL
Enrollment

674

Participants

Timeline

Start Date

May 18, 2018

Primary Completion Date

April 14, 2020

Study Completion Date

May 24, 2020

Conditions
Acute Ischaemic Stroke
Interventions
DRUG

Recombinant human urokinase

Patients receive rhPro-UK 35mg,15mg of which is given as a bolus within 3 minutes followed by dlivery of the remaining 20 mg as a constant infusion over a period of 30 minutes.

DRUG

Alteplase

Patients receive rt-PA in a dose of 0.9mg per kilogram of body weight(maximum,90 mg),10 percent of which was given as a blous followed by delivery of the remaining 90 percent as a constant infusion over a period of 60 minutes.

Trial Locations (35)

100053

First Affiliated Hospital of Baotou Medical College, Baotou

Unknown

Beijing Luhe Hospital,Capital Medical University, Beijing

XuanWu Hospital, Capital Medical University, Beijing

Liuzhou Worker's Hospital, Liuzhou

Cangzhou Central Hospital, Cangzhou

The First Hospital of Handan, Handan

Harrison International Peace Hospital, Hengshui

The First Hospital of Hebei Medical University, Shijiazhuang

The Second Hospital of Hebei Medical University, Shijiazhuang

Tangshan Gongren Hospital, Tangshan

Daqing Oilfield General Hospital, Daqing

The First Affiliated Hospital of Harbin Medical University, Harbin

The Fourth Affiliated Hospital of Harbin Medical University, Harbin

The First Hospital of Changsha, Changsha

Baotou Central Hospital, Baotou

Affiliated Hospital of Inner Mongolia Medical University, Hohhot

Inner Mongolia People's Hospital, Hohhot

Huai'an First People's Hospital, Huai'an

The Second People'Hospital of Huai'an, Huai'an

Nanjing Drum Tower Hospital, Nanjing

The Affiliated Hospital of Xuzhou Medical University, Xuzhou

Xuzhou Central Hospital, Xuzhou

Jiangxi Pingxiang People's Hospital, Pingxiang

First Hospital of Jilin University, Changchun

The Neuropsychiatric Hospital of Jilin Province, Siping

Dalian Municipal Central Hospital, Dalian

Shenyang Military Region General Hospital, Shenyang

The 163th Hospital of the Chinese People's Liberation Army, Shenyang

Liaocheng People's Hospital, Liaocheng

The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an

The People's Hospital of Sichuan Province, Chengdu

Deyang people's hospital, Deyang

Tianjin Huanhu Hospital, Tianjin

Taizhou Hospital of Zhejiang Province, Taizhou

Luoyang Central Hospital, Luoyang

All Listed Sponsors
lead

Tasly Biopharmaceuticals Co., Ltd.

INDUSTRY

NCT03541668 - Study of rhPro-UK in Patients With Acute Ischaemic Stroke in 4.5 Hours After Stroke Onset(PROST) | Biotech Hunter | Biotech Hunter