A Study Designed to Evaluate the Safety and Efficacy of Venetoclax Plus Dexamethasone (VenDex) Compared With Pomalidomide Plus Dexamethasone (PomDex) in Participants With t(11;14)-Positive Relapsed or Refractory Multiple Myeloma.

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

265

Participants

Timeline

Start Date

October 22, 2018

Primary Completion Date

August 31, 2026

Study Completion Date

November 30, 2027

Conditions
Multiple Myeloma
Interventions
DRUG

Pomalidomide

capsule, oral

DRUG

Dexamethasone

oral, locally available form

DRUG

Venetoclax

tablet; oral

Trial Locations (180)

2076

Sydney Adventist Hospital /ID# 222874, Wahroonga

2170

Liverpool Hospital /ID# 202431, Liverpool

2500

Wollongong Hospital /ID# 205545, Wollongong

2730

Duplicate_Herlev Hospital /ID# 223221, Herlev

4000

Duplicate_Roskilde Hospital /ID# 223366, Roskilde

4101

Icon Cancer Centre /ID# 205663, South Brisbane

4812

ICON Cancer Care - Townsville /ID# 206565, Hyde Park

5000

Odense University Hospital /ID# 223217, Odense

5011

The Queen Elizabeth Hospital /ID# 202432, Woodville South

6009

Perth Blood Institute Ltd /ID# 206649, Nedlands

7100

Sygehus Lillebalt, Vejle /ID# 223216, Vejle

9000

Aalborg University Hospital /ID# 223220, Aalborg

10126

A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 170962, Turin

10676

General Hospital of Athens Evaggelismos and Ophthalmiatrio of Athens Polyclinic /ID# 213982, Athens

11528

Alexandra General Hospital /ID# 202386, Athens

12203

Charite Universitaetsklinikum Berlin - Campus Benjamin Franklin /ID# 200051, Berlin

15232

UPMC Hillman Cancer Ctr /ID# 200063, Pittsburgh

17007

Instituto Catalan de Oncologia (ICO) Girona /ID# 171311, Girona

18009

Communal Nonprofit Enterprise Cherkasy Regional Oncology Dispensary /ID# 223943, Cherkasy

20122

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 212498, Milan

20246

Universitaetsklinikum Hamburg-Eppendorf /ID# 215495, Hamburg

21201

University of Maryland, Baltimore /ID# 217422, Baltimore

21565

Duplicate_Gachon University Gil Medical Center /ID# 202827, Incheon

22763

Asklepios Klinik Altona /ID# 222506, Hamburg

24071

Hospital de Leon /ID# 233878, León

24105

Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 201830, Kiel

26504

University Gen Hosp of Patra /ID# 201691, Pátrai

28040

Hospital Universitario Fundacion Jimenez Diaz /ID# 171304, Madrid

28041

Disc_Hospital Universitario 12 de Octubre /ID# 171288, Madrid

28046

Hospital Universitario La Paz /ID# 218107, Madrid

29000

MNI Khmelnytskyi Regional Hospital of Khmelnytskyi Regional Council /ID# 223942, Khmelnytskyi

29603

Hospital Costa del Sol /ID# 234083, Marbella

32005

Complejo Hospitalario Universitario Ourense /ID# 222876, Ourense

32224

Mayo Clinic /ID# 200075, Jacksonville

34093

Istanbul University Istanbul Medical Faculty /ID# 201953, Istanbul

34214

Bagcilar Medipol Mega Universite Hastanesi /ID# 222914, Istanbul

34362

The Lady Davis Carmel Medical Center /ID# 222969, Haifa

34899

Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 201952, Istanbul

35040

Ege University Medical Faculty /ID# 222697, Izmir

35575

Izmir Ekonomi Universitesi Ozel Medicalpoint Hastanesi /ID# 201954, Cordaleo

37711

Hospital Universitario de Salamanca /ID# 171294, Salamanca

38320

Hospital Universitario Canarias /ID# 238452, San Cristóbal de La Laguna

38700

Duplicate_CHU Grenoble - Hopital Michallon /ID# 223182, La Tronche

40138

Duplicate_IRCCS AOU di Bologna - Policlinico Sant'Orsola-Malpighi /ID# 170952, Bologna

41013

Hospital Universitario Virgen del Rocio /ID# 171286, Seville

44000

CHU de Nantes, Hotel Dieu -HME /ID# 200099, Nantes

44033

Ulsan University Hospital /ID# 222716, Ulsan

44195

Cleveland Clinic Main Campus /ID# 202247, Cleveland

45007

Hospital General Universitario de Toledo /ID# 222887, Toledo

46026

Hospital Universitario y Politecnico La Fe /ID# 234019, Valencia

48201

Barbara Ann Karmanos Cancer In /ID# 201377, Detroit

48202

Duplicate_Henry Ford Hospital /ID# 171531, Detroit

51092

CHU Reims - Hôpital Robert Debre /ID# 233907, Reims

54500

CHRU Nancy - Hopitaux de Brabois /ID# 201076, Vandœuvre-lès-Nancy

54639

Theageneio Anticancer Hospital /ID# 213983, Thessaloniki

57010

General Hospital of Thessaloniki George Papanikolaou /ID# 201692, Thessaloniki

59037

CHRU Lille - Hopital Claude Huriez /ID# 202213, Lille

60020

Azienda Ospedaliero Universitaria delle Marche /ID# 170950, Ancona

61070

Communal non-profit enterprise Regional Center of Oncology /ID# 223945, Kharkiv

69495

HCL - Hopital Lyon Sud /ID# 200097, Pierre-Bénite

70736

Robert-Bosch-Krankenhaus /ID# 223947, Stuttgart

71500

University General Hospital of Heraklion PA.G.N.I /ID# 222879, Heraklion

72076

Universitaetsklinikum Tuebingen /ID# 238646, Tübingen

75013

Hopital Pitie Salpetriere /ID# 214173, Paris

76038

Centre Henri Becquerel /ID# 223186, Rouen

79044

SI Institute of Blood Pathology and Transfusion Medicine of NAMS of Ukraine /ID# 223941, Lviv

80045

Rocky Mountain Regional VA Medical Center/Eastern Colorado Health Care System /ID# 222904, Aurora

84902

CH Henri Duffaut /ID# 234154, Avignon

85028

Irccs-Crob /Id# 170955, Rionero in Vulture

90095

University of California, Los Angeles /ID# 171524, Los Angeles

90146

Azienda Ospedaliera Ospedali Riuniti Villa Sofia Cervello /ID# 222988, Palermo

91120

Hadassah /ID# 169474, Jerusalem

94010

Hopitaux Universitaires Henri Mondor - Hopital Henri Mondor /ID# 202211, Créteil

97080

Universitaetsklinikum Wuerzburg /ID# 200055, Würzburg

100020

Beijing Chaoyang Hospital,Capital Medical University /ID# 216014, Beijing

100043

Beijing Chaoyang Hospital, Capital Medical University(West campus) /ID# 234033, Beijing

100191

Peking University Third Hospital /ID# 216371, Beijing

100730

Peking Union Medical College Hospital (East) - Dongdan Campus /ID# 216040, Beijing

110001

The First Hospital of China Medical University /ID# 215996, Shenyang

110022

Shengjing Hospital of China Medical University /ID# 223435, Shenyang

119228

National University Hospital /ID# 203988, Singapore

123182

City Clinical Hospital #52 /ID# 206289, Moscow

125284

Moscow State budget healthcare /ID# 169685, Moscow

169608

Singapore General Hospital /ID# 202131, Singapore

194291

Leningrad Regional Clinical Hospital /ID# 202776, Saint Petersburg

197341

Almazov National Medical Research Centre /ID# 169681, Saint Petersburg

200065

Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 216643, Shanghai

Shanghai Tongji Hospital /ID# 218865, Shanghai

210008

Nanjing Drum Tower Hospital /ID# 223143, Nanjing

215006

The First Affiliated Hospital of Soochow University /ID# 216094, Suzhou

300020

Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sc /ID# 216041, Tianjin

300053

Tula Regional Clinical Hospital /ID# 223226, Tula

300060

Tianjin Medical University Cancer Institute & Hospital /ID# 223550, Tianjin

308433

Tan Tock Seng Hospital /ID# 204374, Singapore

310003

The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 215989, Hangzhou

The First Affiliated Hospital, Zhejiang University School of Medicine /ID# 218691, Hangzhou

325000

The First Affiliated Hospital of Wenzhou Medical University /ID# 218953, Wenzhou

330006

The First Affiliated Hospital of Nanchang University /ID# 216954, Nanchang

357500

LLC Novaya Klinika /ID# 169689, Pyatigorsk

430022

Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 215850, Wuhan

450008

Henan Cancer Hospital /ID# 215987, Zhengzhou

510060

Sun Yat-Sen University Cancer Center /ID# 223828, Guangzhou

510080

Guangdong Provincial People's Hospital /ID# 215860, Guangzhou

610041

West China Hospital, Sichuan University /ID# 216647, Chengdu

630099

Research Institute of Fundamental and Clinical Immunology /ID# 223594, Novosibirsk

3109601

Rambam Health Care Campus /ID# 169678, Haifa

3339419

Bnai Zion Medical Center /ID# 169466, Haifa

4941492

Rabin Medical Center /ID# 244611, Petah Tikva

5265601

The Chaim Sheba Medical Center /ID# 169778, Ramat Gan

6423906

Tel Aviv Sourasky Medical Center /ID# 169437, Tel Aviv

7747629

Duplicate_Assuta Ashdod Medical Center /ID# 222968, Ashdod

8443901

Soroka University Medical Center /ID# 218768, Beersheba

9808574

Tohoku University Hospital /ID# 201935, Sendai

85719-1478

Duplicate_University of Arizona Cancer Center - North Campus /ID# 218407, Tucson

93703-2223

VA Central California Health Care System /ID# 200047, Fresno

33331-3609

Cleveland Clinic Florida /ID# 208884, Weston

40202-3700

Duplicate_Norton Cancer Institute /ID# 200834, Louisville

02118

Boston Medical Center /ID# 223606, Boston

55905-0001

Mayo Clinic - Rochester /ID# 201091, Rochester

10032-3729

Columbia University Medical Center /ID# 200715, New York

44111-5605

Fairview Hospital - Moll Pavilion /ID# 208919, Cleveland

77030-4000

MD Anderson Cancer Center at Texas Medical Center /ID# 200060, Houston

84112-5500

Huntsman Cancer Institute /ID# 218406, Salt Lake City

98108-1597

VA Puget Sound Health Care System /ID# 222708, Seattle

T2N 5G2

Arthur J. E. Child Comprehensive Cancer Centre /ID# 218846, Calgary

V5Z 1L3

BC Cancer - Vancouver /ID# 222804, Vancouver

B3H 2Y9

Queen Elizabeth II Health Sciences Centre - Victoria General /ID# 218883, Halifax

G6V 3Z1

CISSS-CA (Centre Integre de sante et de services sociaux de Chaudiere-Appalache) /ID# 218887, Lévis

625 00

Fakultní Nemocnice Brno - Jihlavská /ID# 204512, Brno

500 05

Fakultní nemocnice Hradec Králové - Sokolská /ID# 221291, Hradec Králové

708 52

Fakultni Nemocnice Ostrava /ID# 204515, Ostrava

779 00

Fakultni nemocnice Olomouc /ID# 221290, Olomouc

128 08

Vseobecna fakultni nemocnice v Praze /ID# 221166, Prague

09116

Klinikum Chemnitz gGmbH /ID# 233797, Chemnitz

07747

Universitaetsklinikum Jena /ID# 201254, Jena

05100

Azienda Ospedaliera Santa Maria Terni /ID# 170948, Terni

467-8602

Nagoya City University Hospital /ID# 170880, Nagoya

277-8567

The Jikei University Kashiwa Hospital /ID# 223031, Kashiwa-shi

812-8582

Kyushu University Hospital /ID# 171117, Fukuoka

503-8502

Ogaki Municipal Hospital /ID# 171043, Ogaki-shi

371-8511

Gunma University Hospital /ID# 170966, Maebashi

730-8619

Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital /ID# 171255, Hiroshima

650-0047

Kobe City Medical Center General Hospital /ID# 170992, Kobe

311-3193

Duplicate_National Hospital Organization Mito Medical Center /ID# 171187, Higashi Ibaraki-gun

317-0077

Hitachi General Hospital /ID# 200843, Hitachi-shi

028-3695

Iwate Medical University Hospital /ID# 222849, Shiwa-gun

701-1192

Okayama Medical Center /ID# 200119, Okayama

543-8555

Japanese Red Cross Osaka Hospital /ID# 171493, Osaka

565-0871

The University of Osaka Hospital /ID# 201966, Suita-shi

770-8503

Tokushima University Hospital /ID# 202571, Tokushima

105-8471

The Jikei University Hospital /ID# 239014, Minato-ku

150-8935

Japanese Red Cross Medical Center /ID# 171256, Shibuya-ku

990-9585

Yamagata University Hospital /ID# 238329, Yamagata

03080

Seoul National University Hospital /ID# 202711, Seoul

06351

Samsung Medical Center /ID# 202710, Seoul

06591

The Catholic University of Korea, Seoul St. Marys Hospital /ID# 234045, Seoul

03722

Yonsei University Health System Severance Hospital /ID# 202709, Seoul

07120

Hospital Universitari Son Espases /ID# 222889, Palma de Mallorca

08035

Hospital Universitario Vall d'Hebron /ID# 218106, Barcelona

971 80

Sunderby sjukhus /ID# 201314, Luleå

501 82

Sodra Alvsborgs sjukhus /ID# 213061, Borås

581 85

Duplicate_Universitetssjukhuset Linköping /ID# 200789, Linkoping

451 80

Uddevalla sjukhus /ID# 201315, Uddevalla

01330

Cukurova Universitesi Tip Fakultesi /ID# 201955, Saricam Adana

06200

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastirma Hastanesi /ID# 201956, Ankara

06560

Gazi University Medical Faculty /ID# 222698, Ankara

06590

Ankara Univ Medical Faculty /ID# 201881, Ankara

03022

National Cancer Institute /ID# 223944, Kyiv

CB2 2QQ

Addenbrooke's Hospital /ID# 223097, Cambridge

W12 0HS

Hammersmith Hospital /ID# 171446, London

NW1 2BU

University College London Hospital /ID# 171428, London

NR4 7UY

Norfolk and Norwich University Hospitals NHS Foundation Trust /ID# 218213, Norwich

NG5 1PB

Duplicate_Nottingham University Hospitals NHS Trust /ID# 223292, Nottingham

G12 0XH

Duplicate_NHS Greater Glasgow and Clyde /ID# 202199, Glasgow

ST4 6QG

Duplicate_University Hospitals North Midlands - Royal Stoke University Hospital /ID# 218355, Stoke-on-Trent

SE13 6LH

Duplicate_Duplicate_Lewisham and Greenwich NHS Trust /ID# 171445, London

M9 2AA

Manchester University NHS Foundation Trust /ID# 171440, Manchester

PO6 3LY

Portsmouth Hospitals University NHS Trust /ID# 171444, Portsmouth

RG1 5AN

Royal Berkshire NHS Foundation Trust /ID# 217835, Reading

S5 7AT

Duplicate_Sheffield Teaching Hospitals NHS Foundation Trust - Royal Hallamshire /ID# 171447, Sheffield

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Roche-Genentech

INDUSTRY

lead

AbbVie

INDUSTRY