Phase II Study of Concurrent Sorafenib and Intensity-modulated Radiotherapy (IMRT) for Advanced Hepatocellular Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

86

Participants

Timeline

Start Date

May 8, 2018

Primary Completion Date

January 31, 2020

Study Completion Date

June 1, 2021

Conditions
Hepatocellular Carcinoma, Radiotherapy, Sorafenib
Interventions
RADIATION

concurrent sorafenib and IMRT, followed sorafenib maintenance

IMRT 40-60Gy/20-30f; concurrent sorafenib 400mg bid po (it can be given to patients in four weeks before IMRT is applied, so that it can control disease during waiting for IMRT); maintenance sorafenib 400mg bid po until disease progress or unacceptable adverse events; six months is recommended but not mandatory.

Trial Locations (1)

100021

Bo Chen, Beijing

All Listed Sponsors
lead

Cancer Institute and Hospital, Chinese Academy of Medical Sciences

OTHER

NCT03535259 - Phase II Study of Concurrent Sorafenib and Intensity-modulated Radiotherapy (IMRT) for Advanced Hepatocellular Carcinoma | Biotech Hunter | Biotech Hunter