Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

106

Participants

Timeline

Start Date

July 20, 2018

Primary Completion Date

December 20, 2022

Study Completion Date

July 6, 2023

Conditions
Vivax MalariaG6PD Deficiency
Interventions
DRUG

Chloroquine

Standard chloroquine (three days)

DRUG

Primaquine

Daily Primaquine (0.5 mg of base/kg/day for seven days) starting only at the fifth day post chloroquine initiation.

DRUG

Primaquine

Weekly primaquine (0.75 mg of base/kg/week for eight weeks) starting with first dose of chloroquine.

DRUG

Chloroquine

Weekly, once a week chloroquine (5 mg of base/kg/week for twelve weeks)

DRUG

Primaquine

Standard primaquine (0.5mg of base/kg/day for seven days) concomitant with chloroquine.

Trial Locations (2)

69040-000

Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus

Unknown

Centro de Pesquisa em Medicina Tropical (Cepem), Porto Velho

All Listed Sponsors
collaborator

Oswaldo Cruz Foundation

OTHER

collaborator

Conselho Nacional de Desenvolvimento Científico e Tecnológico

OTHER_GOV

lead

Fundação de Medicina Tropical Dr. Heitor Vieira Dourado

OTHER

NCT03529396 - Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients | Biotech Hunter | Biotech Hunter