523
Participants
Start Date
May 2, 2018
Primary Completion Date
November 30, 2025
Study Completion Date
November 30, 2027
MCLA-158
full-length IgG1 bispecific antibody targeting EGFR and LGR5
MCLA-158 + Pembrolizumab
MCLA-158 in combination with pembrolizumab will be explored first in HNSCC patients eligible to receive pembrolizumab as first-line monotherapy.
MCLA-158 + FOLFIRI
MCLA-158 in combination with FOLFIRI will be explored in mCRC patients with up to 1 line of prior regimen.
MCLA-158 + FOLFOX
MCLA-158 in combination with FOLFOX will be explored in mCRC patients with up to 1 line of prior regimen.
RECRUITING
Hematology-Oncology Associates of Central New York, Syracuse
RECRUITING
Cayuga Medical Center, Ithaca
RECRUITING
Oncology & Hematology Associates of Southwest Virginia, Roanoke
RECRUITING
Sarah Cannon Research Institute (Lake Nona), Orlando
RECRUITING
Florida Cancer Specialists, Fort Myers
COMPLETED
Sarah Cannon Research Institute, Nashville
RECRUITING
The University Of Tennessee Health Science Center, Memphis
RECRUITING
Taylor Cancer Research Center, Maumee
RECRUITING
Cleveland Clinic, Cleveland
RECRUITING
SSM Health Saint Louis University Hospital, St Louis
RECRUITING
Washington University School of Medicine at St Louis, St Louis
RECRUITING
SSM OKC Hightower Clinical, Oklahoma City
RECRUITING
Texas Oncology, Dallas
RECRUITING
Texas Oncology, Tyler
RECRUITING
Oncology Consultants, Houston
RECRUITING
Rocky Mountain Cancer Centers, Lone Tree
RECRUITING
Utah Cancer Specialists, Salt Lake City
RECRUITING
University of Utah Health Huntsman Cancer Hospital, Salt Lake City
RECRUITING
USC Norris Comprehensive Cancer Center, Los Angeles
RECRUITING
UCSD, La Jolla
RECRUITING
Sharp Healthcare, San Diego
RECRUITING
Cancer Care Northwest, Spokane
RECRUITING
Massachusetts General Hospital - Dana Farber, Boston
RECRUITING
Cliniques universitaires Saint-Luc, Brussels
RECRUITING
Institut Jules Bordet, Brussels
RECRUITING
UZ Gent, Ghent
RECRUITING
Chu Ucl Namur Site De Sainte-Elisabeth, Namur
RECRUITING
Hopital Saint Andre, CHU Bordeaux, Bordeaux
RECRUITING
Centre Leon Berard, Lyon
RECRUITING
Hopital La Timone, Marseille
RECRUITING
Institut Régional du Cancer de Montpellier, Montpellier
RECRUITING
Centre Antoine Lacassagne, Nice
RECRUITING
Institut Curie, Paris
RECRUITING
Institut Gustave Roussy, Paris
RECRUITING
Centre Henri Becquerel, Rouen
RECRUITING
NKI - Antoni van Leeuwenhoek, Amsterdam
RECRUITING
UMC Radboud, Nijmegen
RECRUITING
UMC Utrecht, Utrecht
RECRUITING
Vall d'Hebron, Barcelona
RECRUITING
Hospital 12 de Octubre, Madrid
RECRUITING
Clinica Universidad de Navarra, Pamplona
RECRUITING
Hospital Universitario de Navarra, Pamplona
RECRUITING
Instituto Valenciano de Oncologia, Valencia
COMPLETED
Cambridge University Hospitals NHS Foundation Trust, Cambridge
RECRUITING
Sarah Cannon Research Institute, London
Merus N.V.
INDUSTRY