A Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

PHASE3CompletedINTERVENTIONAL
Enrollment

637

Participants

Timeline

Start Date

August 31, 2018

Primary Completion Date

June 28, 2021

Study Completion Date

June 28, 2022

Conditions
Geographic Atrophy
Interventions
DRUG

APL-2

Complement (C3) Inhibitor

DRUG

APL-2

Complement (C3) Inhibitor

OTHER

Sham Procedure

Subjects will receive a Sham procedure every month

OTHER

Sham Procedure

Subjects will receive a Sham procedure every other month

Trial Locations (112)

128

IRCCS Fondazione G.B. Bietti, Roma

314

Centro de Oftalmologia Barraquer, Barcelona

2000

Save Sight Institute, Sydney

2135

Strathfield Retina Clinic, Strathfield

2145

Sydney West Retina, Westmead

2150

Marsden Eye Specialist, Parramatta

2822

Hospital Universitario Puerta de Hierro, Majadahonda

5000

Adelaide Eye & Retina Clinic, Adelaide

6009

Lions Eye Institute, Nedlands

6525

Radboud University Medical Center Oogheelkunde, Nijmegen

8013

Southern Eye Specialists, Christchurch

10003

New York Eye and Ear Infirmary of Mount Sinai, New York

10022

Vitreous Retina Macula Consultants of NY, New York

11563

Ophthalmic Consultants of Long Island, Lynbrook

15122

AIO Visionary Eye Care, West Mifflin

15146

Retina Vitreous Consultants, Monroeville

18017

Mid Atlantic Retina, Bethlehem

19107

Mid Atlantic Retina, Wills Eye Hospital, Philadelphia

20132

Ospedale San Raffaele, Milan

20157

Luigi Sacco Hospital, Milan

20815

The Retina Group of Washington, Chevy Chase

21209

The Retina Care Center, Baltimore

21740

Cumberland Valley Retina Center, Hagerstown

Mid Atlantic Retina Specialists, Hagerstown

22046

Emerson Clinical Research Institute, Falls Church

23538

Universitätsklinikum Schleswig-Holstein, Lübeck

27710

Duke University, Duke Eye Center, Durham

30909

Southeast Retina Center, PC, Augusta

32503

Retina Specialty Institute, Pensacola

33076

CHU de Bordeaux, Bordeaux

33136

Bascom Palmer Eye Institute, Miami

33761

Blue Ocean Clinical Research / The Macula Center, Clearwater

33880

Center for Retina and Macular Disease, Winter Haven

33912

National Ophthalmic Research Institute (Retina Consultants of Southwest Florida), Fort Myers

34103

Bascom Palmer Eye Institute of Naples, Naples

37075

Universitätsmedizin Göttingen Georg-August-Universität, Göttingen

37203

Tennessee Retina, PC, Nashville

38138

Charles Retina Institute, Germantown

40509

Retina and Vitreous Associates of Kentucky, PSC dba Retina Associates of Kentucky, Lexington

46290

Midwest Eye Institute, Indianapolis

48105

Michigan Medicine Kellogg Eye Center, Ann Arbor

48145

Augenzentrum am St. Franziskus-Hospital, Münster

48149

Universitäts-Augenklinik, Münster

49564

Associated Retinal Consultants, P.C, Grand Rapids

53127

Universitäts-Augenklinik Bonn, Bonn

53705

University of Wisconsin, Madison

55435

VitreoRetinal Surgery PA, Minneapolis

60611

Northwestern Feinberg School of Medicine, Chicago

60612

Rush University Medical Center, Chicago

61704

Gailey Eye Clinic Retina Center, Bloomington

67091

CHU de Strasbourg Hopital Civil, Strasbourg

69130

Clinique du Val d'Ouest, Écully

70006

Retina Associates New Orleans, Metairie

72076

STZ Eyetrial, Tübingen

73013

Research - Retina Vitreous Center, Edmond

75010

Hopital Lariboisière, Paris

75012

CHNO des Quinze-Vingts, Paris

75015

Centre Ophtalmologique d'Imagerie et Laser, Paris

75231

Texas Retina Associates, Dallas

76001

Gemini Eye Clinic, Zlín

76087

Strategic Clinical Research Group, Willow Park

77025

Houston Eye Associates, Houston

77030

Retina Consultants of Houston, PA, Houston

78215

San Antonia Eye Center, San Antonio

78240

Medical Center Ophthalmology Associates, San Antonio

Retina Associates of South Texas, San Antonio

Retinal Consultants of San Antonio, San Antonio

78251

Brown Retina Institute, San Antonio

79106

University Opthalmology Clinic, Freiburg im Breisgau

79606

Retina Research Institute of Texas, Abilene

80336

Augenklinik der LMU München, München

80401

Colorado Retina Associates, Golden

81301

Southwest Retina Research Center, LLC, Durango

84132

University of Utah - John A. Moran Center, Salt Lake City

85021

Arizona Retina & Vitreous Consultants, Phoenix

87109

Vision Research Center Eye Associates of NM, Albuquerque

89502

Sierra Eye Associates, Reno

90211

Retina Vitreous Associates Medical Group, Beverly Hills

91105

Doheny Eye Center UCLA, Pasadena

91120

Hadassah Medical Center, Jerusalem

92064

Retina Consultants San Diego, Poway

92093

University of California, San Diego, Jacobs Retina, La Jolla

92647

Atlantis Eyecare, Huntington Beach

92705

Orange County Retina Medical Group, Santa Ana

92835

Retina Consultants of Orange County, Fullerton

93103

California Retina Consultants, Santa Barbara

93309

California Retina Consultants, Bakersfield

94010

Centre Hospitalier Intercommunal de Créteil, Créteil

94303

Byers Eye Institute at Stanford, Stanford School of Medicine, Palo Alto

95508

Retinal Diagnostic Center, Campbell

95819

Retinal Consultants Med Group, Inc., Sacramento

97405

Oregon Retina, LLP, Eugene

3109601

Rambam Medical Centre, Haifa

3436212

Carmel Medical Center, Haifa

06385

Retina Group of New England, Waterford

02116

Tufts Medical Center, Boston

01107

New England Retina Consultants, Springfield

07003

Retina Center of NJ, LLC, Bloomfield

08755

NJ Retina, Toms River

04021-001

UNIFESP - Federal University, São Paulo

M5T 2S8

UHN Toronto Western Hospital, Toronto

150 00

AXON Clinical S.R.O, Prague

21 079

CHU Dijon, Bordeaux

1105 AZ

Academisch Medisch Centrum, Amsterdam

85-316

Oculomedica Eye Centre, Bydgoszcz

85-631

Oftalmika Eye Hospital, Bydgoszcz

35-017

Eye Surgery Center Professor Zagorski, Rzeszów

08022

Centro Médico Teknon, Barcelona

BT12 6BA

The Royal Victoria Hospital, Belfast

L7 8XP

Liverpool University Hospitals NHS Foundation Trust, Liverpool

SR2 9HP

Sunderland Eye Infirmary, Sunderland

YO31 8HE

York Teaching Hospital NHS Foundation Trust, York

Sponsors
All Listed Sponsors
lead

Apellis Pharmaceuticals, Inc.

INDUSTRY