Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration

PHASE3CompletedINTERVENTIONAL
Enrollment

621

Participants

Timeline

Start Date

August 31, 2018

Primary Completion Date

June 21, 2021

Study Completion Date

June 20, 2022

Conditions
Geographic Atrophy
Interventions
DRUG

APL-2

Complement (C3) Inhibitor

DRUG

APL-2

Complement (C3) Inhibitor

OTHER

Sham Procedure

Subjects will receive a Sham procedure every month

OTHER

Sham Procedure

Subjects will receive a Sham procedure every other month

Trial Locations (141)

1052

Retina Specialist, Auckland

1288

Oftalmologos Especialistas, Rosario

2000

Microcirugia Ocular, El Rosario

Sydney Retina, Sydney

3002

Centre for Eye Research Australia, East Melbourne

3204

Hamilton Eye Clinic, Hamilton

5500

Oftar Mendoza SRL, Mendoza

10022

Vitreous Retina Macula Consultants of NY, New York

11021

Long Island Vitreoretinal Consultants, Great Neck

13008

Centre Monticelli Paradis, Marseille

15706

Instituto Oftalmologico Gómez-Ulla, Santiago de Compostela

19006

Mid Atlantic Retina, Philadelphia

20132

Ospedale San Raffaele, Milan

20157

Luigi Sacco Hospital, Milan

20186

Virginia Retina Center, Warrenton

21204

Retina Specialists, Towson

21236

Elman Retina Group, PA, Baltimore

21740

Cumberland Valley Retina Consultants, PC, Hagerstown

Mid Atlantic Retina Specialists, Hagerstown

22031

The Retina Group of Washington, Fairfax

22903

University of Virginia, Charlottesville

28210

Charlotte Eye Ear Nose and Throat Associates, PS, Charlotte

28602

Graystone Eye, Hickory

28803

Western Carolina Retinal Associates, Asheville

30060

Georgia Retina, Marietta

30909

Southeast Retina Center, PC, Augusta

32308

Southern Vitreoretinal Associates, Tallahassee

33309

Pinnacle Research Institute, Fort Lauderdale

33418

Bascom Palmer Eye Institute, Palm Beach Gardens

33426

Florida Eye Microsurgical Institute, Inc., Boynton Beach

33609

Retina Associates of Florida, Tampa

33612

University of South Florida (USF) Eye Institute, Tampa

33782

Eye Associates of Pinellas, Pinellas Park

33907

Retina Health Center, Fort Myers

34994

East Florida Eye Institute, Stuart

37203

Tennessee Retina, PC, Nashville

37540

Centre Ophthalmologique Saint-Exupery, Saint-Cyr-sur-Loire

43212

The Ohio State University, Columbus

44093

CHU de Nantes - Hotel Dieu, Nantes

44122

Retina Associates of Cleveland, Inc., Cleveland

Retina Associates of Cleveland, Inc, Cleveland

44130

Retina Associates of Cleveland, Cleveland

44195

Cleveland Clinic, Cole Eye Institute, Cleveland

44505

Retina Associates of Cleveland, Inc., Youngstown

46290

Midwest Eye Institute, Indianapolis

47006

Hospital Universitario Rio Hortega, Valladolid

48034

Retina Consultants of Michigan, Southfield

49100

Rabin Medical Center, Petah Tikva

49546

Associated Retinal Consultants, P.C, Grand Rapids

Retina Specialists of Michigan / Foundation for Vision, Grand Rapids

49686

Associated Retinal Consultants PC, Traverse City

50937

University Hospital Cologne, Cologne

53002

OFTEX Eye Clinic, Pardubice

53127

Universitäts-Augenklinik Bonn, Bonn

53715

University of Wisconsin, Madison

57701

Black Hills Regional Eye Institute, Rapid City

64239

Tel Aviv Sourasky Medical Center, Tel Aviv

66211

Sabates Eye Center, Leawood

67000

Maison Rouge Ophthalmologic Center, Strasbourg

67063

Klinikum der Stadt Ludwigshafen gGmbH, Ludwigshafen

69004

Hopital de la Croix-Rousse, Lyon

75006

Centre Ophtalmologique de l´Odéon, Paris

76100

Kaplan Medical Center, Rehovot

77030

Retina Consultants of Houston, PA, Houston

77384

Retina Consultants of Houston, The Woodlands

78240

Medical Center Ophthalmology Associates, San Antonio

Retinal Consultants of San Antonio, San Antonio

78503

Valley Retina Institute, PA, McAllen

78705

Retina Consultants of Austin (Retina Research Center), Austin

79106

Southwest Retina Specialists, Amarillo

79606

Retina Research Institute of Texas, Abilene

81675

Klinikum rechts der Isar, München

84107

Retina Associates of Utah, PC, Murray

85014

Retinal Research Institute, Phoenix

85020

Associated Retina Consultants, Ltd, Phoenix

89503

Sierra Eye Associates, Reno

90211

Retina Vitreous Associates Medical Group, Beverly Hills

91007

Retina Institute of California dba Acuity Eye Grp, Arcadia

91436

The Retina Partners, Encino

92064

Retina Consultants San Diego, Poway

92260

Retina Institute of California Medical Group, Palm Desert

92374

Retina Consultants of Southern California, Redlands

92697

The Gavin Herbert Eye Institute/UC Irvine, Irvine

93053

Universitätsklinikum Regensburg, Regensburg

93103

California Retina Consultants, Santa Barbara

93309

California Retina Consultants, Bakersfield

94040

Northern California Retina Vitreous Associates, Mountain View

94303

Byers Eye Institute at Standford, Stanford School of Medicine, Palo Alto

94598

Bay Area Retina Associates, Walnut Creek

97080

University Hospital Würzburg, Würzburg

97221

Retina Northwest, PC, Portland

97225

Eye Health Northwest, Portland

98004

Vitreoretinal Associates of Washington, Bellevue

99204

Spokane Eye Clinical Research, Spokane

3109601

Rambam Medical Center, Haifa

4428164

Meir Medical Center, Kfar Saba

7030000

Shamir Medical Center, Be’er Ya‘aqov

06810

Danbury Eye Physicians & Surgeons, P.C. - Danbury, Danbury

06518

New England Retina Associates, Hamden

06385

Retina Group of New England,PC, Waterford

02114

Ophthalmic Consultants of Boston, Boston

01107

New England Retina Consultants, PC, Springfield

07666

Retina Associates of New Jersey (NJ Retina), Teaneck

C1023 AAQ

Fundacion Zambrano, Buenos Aires

S2000 AZH

Grupo Laser Vision, Rosario

C1015 ABO

Organizacion Medica de investigacion, Buenos Aires

C1116ABA

Centro Oftalmologico Dr Charles, Buenos Aires

C1425BGE

Diagnostico Ocular, Buenos Aires

X5000AAJ

Centro Privado de Ojos Romagosa SA, Córdoba

X5000III

Instituto Oftalmologico de Cordoba, Córdoba

NSW 2220

Retina and Eye Consultants, Hurstville

29055-45

Clinica Ocular Oftalmologia LTDA, Vitória

06010-130

Clinica Oftalmologica Sao Lucas, Osasco

04038-032

IPEPO - Instituto Da Visao, São Paulo

32150-274

Instituto da Visão - Hospital de Olhos Ltda, Belo Horizonte

90036-903

Hospital De Clinicas De Porto Alegre, Porto Alegre

04021-001

UNIFESP - Federal University, São Paulo

N6A

Ivey Eye Institute, London

K1H 8L6

University of Ottawa Eye Institute, Ottawa

M5C 1R6

DRY AMD Clinic - St. Michael's Hospital, Toronto

K2B 7E9

Retina Centre of Ottawa, Ottawa

708 52

Fakultní nemocnice Ostrava, Ostrava-Poruba

150 00

AXON Clinical, S.R.O., Prague

100 34

University Hospital Kralovske Vinochrady, Vinohrady

Unknown

Centre Hospitalier Intercommunal de Créteil, Créteil

85-631

Oftalmika Eye Hospital, Bydgoszcz

91-134

Jasne Blonia Eye Clinic, Lodz

10-424

Centrum Diagnostyki i Mikrochirurgii Oka - LENS, Olsztyn

33-100

Centrum Medyczne UNO-MED, Tarnów

00612

Emanuelli Research and Development Center, Arecibo

08022

Centro Médico Teknon, Barcelona

EC1V 2PD

Moorfields Eye Hospital NHS Foundation Trust, London

HD3 3EA

Eye Clinic, Acre Mill Outpatients, Huddersfield Royal Infirmary, Huddersfield

BS1 2LX

Bristol Eye Hospital, Bristol

LS9 7TF

St James's University Hospital, Leeds

LEI 5WW

Leicester Royal Infirmary, Leicester

NW10 7NS

London North West University Hospital Trust, London

SE5 9RS

King's College Hospital NHS Trust, London

OX3 9DU

Oxford Eye Hospital, Oxford

SP2 8BJ

Salisbury NHS Foundation Trust, Salisbury

SR2 9HP

Sunderland Eye Infirmary, Sunderland

Sponsors
All Listed Sponsors
lead

Apellis Pharmaceuticals, Inc.

INDUSTRY

NCT03525600 - Study to Compare the Efficacy and Safety of Intravitreal APL-2 Therapy With Sham Injections in Patients With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration | Biotech Hunter | Biotech Hunter