A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

927

Participants

Timeline

Start Date

May 28, 2018

Primary Completion Date

January 15, 2026

Study Completion Date

December 4, 2026

Conditions
Progressive Multiple Sclerosis (PMS)
Interventions
DRUG

Ocrelizumab

Ocrelizumab will be administered via intravenous (IV) infusion at an initial dose of two 300-mg infusions separated by 14 days (on Days 1 and 15), and then 600 mg at every subsequent dose every 24 weeks for the remainder of the study treatment period (approximately 192 weeks)

Trial Locations (125)

9

Beaumont Hospital, Dublin

1083

Semmelweis Egyetem AOK, Budapest

2500

VALEOMED Diagnosztikai Központ, Esztergom

2600

Rigshospitalet, Glostrup Municipality

4400

Jósa András Oktatókórház, Nyíregyháza

6400

Hjerne- og nervesygdomme, Ambulatorium, Skleroseklinikken, Sønderborg

7623

Pécsi Tudományegyetem, Klinikai Központ Neurológiai Klinika, Pécs

8200

Aarhus Universitetshospital, Aarhus N

10000

Hopital Cheikh Zaid, Rabat

10043

Azienda Sanitaria Ospedaliera S. Luigi Gonzaga, Orbassano

10100

Hopital Militaire d'Instruction Mohamed V, Rabat

10101

Hospital Clínica Biblica, San José

10126

AOU Città della Salute e della Scienza, Turin

11566

Ain Shams University Hospital, Cairo

12110

The MS Center of Northeastern New York, Latham

13005

CHU de la Timone - Hopital d Adultes, Marseille

14033

CHU De Caen, Caen

14050

Unidad de investigacion en salud (UIS), Mexico City

16132

Irccs A.O.U.San Martino Ist, Genoa

17475

Universitätsmedizin Greifswald, Greifswald

19104

University of Pennsylvania, Philadelphia

20132

IRCCS Ospedale San Raffaele, Milan

20133

Fond. Istituto Neurologico C.Besta, Milan

21561

Clinical Research Center-Alex university, Alexandria

26655

Studienzentrum Nordwest Dr med Joachim Springub Herr Wolfgang Schwarz, Westerstede

27100

IRCCS Istituto Neurologico C. Mondino?Dip. Neurologia Neuroriabilitazione S.S. Sclerosi Multipla, Pavia

30000

Centre Hospitalier Universitaire Hassan II, Fes

30029

GroupeHospitalo-Universitaire Caremeau, Nîmes

33076

Groupe Hospitalier Pellegrin, Bordeaux

33613

University of South Florida, Tampa

34149

Ospedale Cattinara, Trieste

34295

Hopital Gui de Chauliac, Montpellier

35033

Centre Hospitalier Universitaire de Rennes, Rennes

37134

Policlinico G.B. Rossi, Verona

38018

Neurology Clinic PC, Cordova

44093

Hopital Nord Laennec, Nantes

44195

Cleveland Clinic Mellen Center, Cleveland

45267

University of Cincinnati, Cincinnati

46026

Hospital Universitario la Fe, Valencia

48210

Wayne State University School of Medicine, Detroit

50134

AOUC Azienda Ospedaliero-Universitaria Careggi, Florence

54035

CHRU Nancy, Nancy

58633

Nemocnice Jihlava, Jihlava

59037

Hopital B Roger Salengro, Lille

63003

Hopital Gabriel Montpied CHU de Clermont-Ferrand, Clermont-Ferrand

63110

Washington University School of Medicine, St Louis

64109

CHIC Cote Basque Bayonne, Bayonne

65191

Deutsche Klinik für Diagnostik, Wiesbaden

67091

Hopitaux Universitaires de Strasbourg, Strasbourg

69677

Hopital neurologique Pierre Wertheimer - CHU Lyon, Bron

70124

Azienda Ospedaliero Universitaria Consorziale Policlinico di, Bari

70182

NeuroConcept AG C/O mind mvz GmbH, Stuttgart

71000

Clinical Center University of Sarajevo, Sarajevo

75000

University Clinical Center Tuzla, Tuzla

78000

University Clinical Center of the Republic of Srpska, Banja Luka

78258

Lone Star Neurology of San Antonio, San Antonio

78681

Central Texas Neurology Consultants, Round Rock

80131

A. O. U. Federico II, Napoli

Università degli Studi della Campania Luigi Vanvitelli, Napoli

80138

Università degli studi della Campania Luigi Vanvitelli, Napoli

80480

CHU Amiens Hopital Sud, Salouël

86077

IRCCS Istituto Neurologico Neuromed, Pozzilli

88000

University Hospital Mostar, Mostar

89073

NeuroPoint Gesellschaft fur vorbeugende Gesundheitspflege mbH, Ulm

91105

SC3 Research Group, Inc, Pasadena

92653

MS Center of California, Laguna Hills

94158

University of California San Francisco, San Francisco

95123

AOU Policlinico V. Emanuele - P.O G. Rodolico, Catania

98122

Swedish Multiple Sclerosis Center, Seattle

112412

Cleveland Clinic Abu Dhabi, Abu Dhabi

117186

Jusupovskaya Hospital, Moscow

125367

Scientific Neurology Center, Moscow

127015

City Clinical Hospital #24, Moskva

129110

Vladimirskiy Regional Scientific Research Inst., Moscow

197110

National Center of Social Significant Disease, Saint Petersburg

06473

Yale University, North Haven

60637-1470

University of Chicago, Chicago

02114

Massachusetts General Hospital, Boston

02481

Dragonfly Research, LLC, Wellesley

81210-310

Instituto de Neurologia de Curitiba, Curitiba

90610-000

Hospital Sao Lucas - PUCRS, Porto Alegre

14051-140

Hospital das Clínicas Faculdades Médicas de Ribeirão Preto, Ribeirão Preto

05403-000

Hospital das Clinicas - FMUSP_X, São Paulo

V5G 2X6

Fraser Health Authority - Fraser Health Multiple Sclerosis, Burnaby

V6T 2B5

University of British Columbia Hospital, Vancouver

N6A 5A5

London Health Sciences Centre Uni Campus, London

M5B 1W8

St. Michael'S Hospital, Toronto

J4V 2J2

Recherche Sepmus Inc., Greenfield Park

H2L 4M1

Hospital Notre-Dame du Centre Hospitalier de l'Universite de Montreal, Montreal

S7K 0M7

Saskatoon City Hospital, Saskatoon

Unknown

Organizacion Sanitas Internacional, Bogotá

Fundacion Clinica Valle del Lili, Santiago de Cali

Cork University Hospital, Cork

Lebanese American University Medical Center- Rizk Hospial, Beirut

Consultorios Médicos PaItilla, Panama City

Hospital Universitario Virgen de Arrixaca, Murcia

Rashid hospital, Dubai

779 00

Fakultní Nemocnice Olomouc, Olomouc

708 52

Fakultni nemocnice Ostrava, Ostrava-Poruba

128 08

Vseobecna fakultni nemocnice v Praze, Prague

06002

Hôpital Pasteur, Nice

01307

"Universitätsklinikum Carl Gustav Carus, Zentrum für Klinische Neurowissenschaften", Dresden

01015

Nucare, Guatemala City

Dublin 4

St Vincents University Hospital, Dublin

00133

Policlinico Tor Vergata Dip. Neuroscienze-Clinica Neurologica-UOSD Sclerosi Multipla, Rome

00168

Policlinico Universitario A. Gemelli, Rome

00189

A.O. Sant'Andrea, Rome

Azienda Ospedaliera Sant'Andrea, Rome

09126

Ospedale Binaghi, Cagliari

11-236

American University of Beirut - Medical Center, Beirut

03100

Grupo Medico de Investigacion Clinica Multidisciplinaria, Mexico City

06700

Clinstile S.A de C.V., Mexico City

06726

Hospital General de Mexico, Mexico

4818 CK

Amphia Ziekenhuis, Breda

5623 EJ

Catharina ziekenhuis, Eindhoven

3079 DZ

Maasstadziekenhuis, NL -rotterdam

6162 BG

Zuyderland Medisch Centrum - Sittard Geleen, Sittard-Geleen

15-276

Uniwersytecki Szpital Kliniczny w Bialymstoku, Bialystok

31-503

Szpital Uniwersytecki w Krakowie, Krakow

90-324

Centrum Neurologii Krzysztof Selmaj, Lodz

60-355

SP Swiecickiego UM Marcinkowskiego, Późna

35-055

"Centrum Medyczne MEDYK", Rzeszów

04-141

Wojskowy Instytut Medyczny - Pa?Stwowy Instytut Badawczy, Warsaw

41-800

SPSK nr 1, Zabrze

08035

Hospital Vall d'Hebron, Barcelona

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY