608
Participants
Start Date
August 1, 2018
Primary Completion Date
June 30, 2022
Study Completion Date
July 31, 2025
Trastuzumab deruxtecan
DS-8201a is sterile lyophilized powder reconstituted into a sterile aqueous solution (100 mg/5 mL) to be administered as intravenous (IV) dose
Capecitabine
Investigator's choice Standard of Care when combined with trastuzumab or lapatinib
Lapatinib
Investigator's choice Standard of Care when combined with capecitabine
Trastuzumab
Investigator's choice Standard of Care when combined with capecitabine
Universitair Ziekenhuis Brussel, Brussels
Cliniques Universitaires Saint-Luc, Brussels
St Vincent's Hospital Sydney, Darlinghurst
Macquarie University Hospital, Sydney
Liverpool Hospital, Liverpool
The Tweed Hospital, Tweed Heads
Calvary North Adelaide Hospital, Bruce
Peter MacCallum Cancer Centre, Melbourne
UZ Leuven, Leuven
Sunshine Hospital, Saint Albans
Austin Health, Heidelberg
Box Hill Hospital, Box Hill
Frankston Hospital, Frankston
Peninsula and South Eastern Haematology & Oncology Group, Frankston
South West Oncology, Warrnambool
Ballarat Oncology & Haematology Service, Wendouree
Princess Alexandra Hospital, Woolloongabba
CHU UCL Namur site de Sainte Elisabeth, Namur
Ashford Cancer Centre Research, Kurralta Park
St John of God Subiaco Hospital, Subiaco
Ankara Yildirim Beyazit Uni. Med. Fac.Ankara City Hospital, Ankara
Hospital del Mar, Barcelona
Az Groeninge, Kortrijk
AZ Maria Middelares, Ghent
Memorial Sloan-Kettering Cancer Center (MSKCC) - New York, New York
Azienda Ospedaliera Città della Salute e della Scienza di Torino, Torino
National Cancer Center, Goyang-si
Hospital de Especialidades de Jerez de la Frontera, Jerez de la Frontera
251 General Air Force Hospital, Athens
"General Hospital of Athens Alexandra", Athens
North Shore Hematology Oncology Associates, PC, East Setauket
Helios-Kliniken Berlin-Buch, Berlin
Seoul National University Bundang Hospital, Seongnam-si
Hôpital Nord - CHU Marseille, Marseille
Centre François Baclesse, Caen
"General Oncology Hospital of Kifissia Agioi Anargyroi", Athens
Complejo Hospitalario Universitario A Coruña, A Coruña
Allegheny General Hospital, Pittsburgh
UPMC Cancer Center, Pittsburgh
Uludag University Medical Faculty, Bursa
Istituto Nazionale per la Ricerca sul Cancro di Genova, Genova
The Catholic University of Korea, St. Vincent's Hospital, Suwon
Ajou University Hospital, Suwon
Abramson Cancer Center, Philadelphia
Washington Cancer Institute, Washington D.C.
Ospedale San Raffaele, Milan
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan
IEO Istituto Europeo di Oncologia, Milan
Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo), Monza
Centre Georges François Leclerc, Dijon
University of Maryland, Baltimore
Virginia Cancer Specialists, PC, Fairfax
CARIO - Centre Armoricain de Radiothérapie, Imagerie médicale et Oncologie, Plérin
Inha University Hospital, Incheon
Universitaetsklinikum Schleswig-Holstein - Campus Luebeck, Lübeck
Azienda Ospealiera della Provincia di Lecco, Lecco
Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII), Bergamo
CHU Besançon - Hôpital Jean Minjoz, Besançon
Hospital Universitari Arnau de Vilanova, Lleida
Fondazione IRCCS Policlinico San Matteo, Pavia
Hospital General Universitario Gregorio Marañon, Madrid
MD Anderson Cancer Centre, Madrid
Hospital Universitario Clinico San Carlos, Madrid
Chungbuk National University Hospital, Cheongju-si
Hospital Clinico Universitario Virgen de la Victoria, Málaga
CHU Brest - Hôpital Morvan, Brest
Piedmont Cancer Institute, PC, Atlanta
IRCCS Centro di Riferimento Oncologico, Aviano
Florida Cancer Specialists-Broadway, Fort Myers
Oncobio Servicos de Saude, Nova Lima
Clinique Clementville, Montpellier
Istanbul University Cerrahpasa - Cerrahpasa Medical Faculty, Istanbul
Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Istanbul
Medipol University Medical Faculty, Istanbul
Institut Régional du Cancer de Montpellier, Montpellier
Institut Régional du Cancer de Montpellier, Montpellier
Medical Park Goztepe Hospital, Istanbul
Istanbul Medeniyet Uni Goztepe Training & Research Hospital, Istanbul
Kartal Lutfi Kirdar Research and Training Hospital, Istanbul
CRLCC Eugene Marquis, Rennes
IOV - Istituto Oncologico Veneto IRCCS, Padua
Izmir Medicalpark Hospital, Izmir
Ospedale Sacro Cuore Don Calabria, Negrar
SCRI - Tennessee Oncology, Nashville
Hospital Universitario de Salamanca, Salamanca
Tennessee Oncology, PLLC Chattanooga, Chattanooga
The West Clinic, Germantown
Hospital Universitario de Canarias, San Cristóbal de La Laguna
Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi, Bologna
Norton Cancer Institute, Louisville
Universitaetsklinikum Duesseldorf AoeR, Düsseldorf
Hospital Universitario Virgen Macarena, Seville
Hospital Universitario Virgen del Rocio, Seville
A.O.U. Policlinico di Modena, Modena
Kyungpook National University Chilgok Hospital, Daegu
Konya Necmettin Erbakan University Meram Faculty of Medicine, Konya
Azienda Ospedaliero Universitaria di Parma, Parma
The Ohio State University, Columbus
Azienda Ospedaliera Universitaria Arcispedale Sant'Anna, Cona
Cleveland Clinic Main Campus, Cleveland
University of Cincinnati Medical Center, Cincinnati
Dayton Physicians, LLC, Kettering
Instituto Valenciano de Oncologia IVO, Valencia
Marienhospital Bottrop gGmbH, Bottrop
Community Hospital, Munster
Universitaetsklinikum Muenster, Müenster
Henry Ford Hospital, Detroit
Rabin Medical Center-Beilinson Campus, Petah Tikva
Hospital Universitario Miguel Servet, Zaragoza
Kliniken Koeln, Cologne
Chaim Sheba Medical Center, Ramat Gan
Haematologisch-Onkologische Schwerpunktpraxis, Troisdorf
Sakarya Traning and Research Hospital, Sakarya
Euromedica General Clinic Thessaloniki, Thessaloniki
Medical Park Samsun Hastanesi, Samsun
Azienda Ospedaliero Universitaria Pisana, Pisa
Centre Oscar Lambret, Lille
Namik Kemal University, Tekirdağ
Centre de cancerologie les Dentellieres, Valenciennes
Loyola University Health System, Maywood
Washington University, St Louis
Centre Hospitalier de la côte Basque, Bayonne
Saint Luke's Cancer Institute, Kansas City
Health Midwest Ventures Group, Inc d/b/a HCA MidAmerica Division, LLC, Kansas City
Cornell-Beshore Cancer Institute, Joplin
Centre Hospitalier Lyon Sud, Pierre-Bénite
University General Hospital of Heraklion, Heraklion
Clinique Victor Hugo - Centre Jean Bernard, Le Mans
Institut Curie - site de Paris, Paris
Institut Curie - site de Paris, Paris
Hopital Tenon, Paris
UT Southwestern Medical Center, Dallas
The University of Texas Health Science Center at Tyler, Tyler
Centre Henri Becquerel, Rouen
MD Anderson Cancer Center, Houston
The Methodist Hospital Research Institute, Houston
Istituto Nazionale Tumori Fondazione G. Pascale, Napoli
Klinikum der Universitaet Muenchen - Campus Grosshardern, Munich
Klinikum rechts der Isar der TU Muenchen, Munich
Community Cancer Trials of Utah, Ogden
Institut Sainte Catherine, Avignon
Ironwood Cancer Research Centers, Chandler
UCLA Hematology Oncology - Main Site, Los Angeles
Innovative Clinical Research Institute, Whittier
Universitaetsklinikum Erlangen, Erlangen
Centre René Huguenin, Saint-Cloud
Sharp Memorial Hospital, San Diego
Hôpital Privé d'Antony, Antony
Pacific Cancer Care, Monterey
Institut Gustave Roussy, Villejuif
Kapiolani Medical Center for Women and Children/Univ of HI, Honolulu
Azienda Ospedaliera Ospedali Riuniti Papardo-Piemonte, Messina
MultiCare Health System Institute for Research and Innovation, Tacoma
Rambam Health Care Center, Haifa
Sapir Medical Center, Meir Hospital, Kfar Saba
Tel Aviv Sourasky Medical Center, Tel Aviv
Shaare Zedek Medical Center, Jerusalem
Hadassah University Hospital - Ein Kerem, Jerusalem
Smilow Cancer Hospital at Yale New Haven, New Haven
Maine Center for Cancer Medicine, Scarborough
Beth Israel Deaconess Medical Center, Boston
Dana Farber Cancer Institute, Boston
Pronutrir, Fortaleza
NOB - Núcleo de Oncologia da Bahia, Salvador
AMO - Assistência Multidisciplinar em Oncologia, Salvador
HGB - Hospital Giovanni Battista - Mãe de Deus Center, Porto Alegre
CliniOnco - Tratamento Integrado do Câncer, Porto Alegre
Escosteguy Barrios, Carlos Henrique, Porto Alegre
Hospital Nossa Senhora da Conceição, Porto Alegre
Clínica de Neoplasias Litoral Ltda., Itajaí
CEPHO - Centro de Estudos e Pesquisas de Hematologia e Oncologia, Santo André
IBCC - Instituto Brasileiro de Controle do Câncer, São Paulo
COI - Clínicas Oncológicas Integradas, Rio de Janeiro
Sociedade Beneficiente de Senhoras Hospital Sírio Libanês, São Paulo
A. C. Camargo Cancer Center, São Paulo
Fakultni nemocnice Brno, Brno
Fakultni nemocnice Olomouc, Olomouc
Fakultni nemocnice v Motole, Prague
Nemocnice Na Bulovce, Prague
Universitaetsklinikum Leipzig AoeR, Leipzig
Fukushima Medical University Hospital, Fukushima
Kindai University Hospital, Osakasayama-shi
Kindai University Hospital, Ōsakasayama-shi
National Cancer Center Hospital, Chūōku
NHO Shikoku Cancer Center, Ehime
NHO Kyushu Cancer Center, Fukuoka
Hiroshima City Hiroshima Citizens Hospital, Hiroshima
NHO Hokkaido Cancer Center, Hokkaido
Hyōgo College of Medicine Hospital, Hyōgo
St. Marianna University School of Medicine Hospital, Kanagawa
Kanagawa Cancer Center, Kanagawa
Kyoto University Hospital, Kyoto
Tohoku University Hospital, Miyagi
Aichi Cancer Center Hospital, Nagoya
Niigata Cancer Center Hospital, Niigata
Okayama University Hospital, Okayama
NHO Osaka National Hospital, Osaka
Osaka International Cancer Institute, Osaka
Saitama Cancer Center, Saitama
Shizuoka Cancer Center, Shizuoka
Toranomon Hospital, Tokyo
The Cancer Institute Hospital of JFCR, Tokyo
Tokyo Medical University Hospital, Tokyo
Korea University Anam Hospital, Seoul
Seoul National University Hospital, Seoul
Severance Hospital, Yonsei University, Seoul
Asan Medical Center, Seoul
Samsung Medical Center, Seoul
The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul
ICO Badalona - Hospital Universitari Germans Trias i Pujol, Badalona
ICO l'Hospitalet - Hospital Duran i Reynals, L'Hospitalet de Llobregat
Hospital Infanta Cristina, Badajoz
Hospital Quironsalud Barcelona, Barcelona
Hospital Universitari Vall d'Hebron, Barcelona
Hospital Clinic de Barcelona, Barcelona
Acibadem Adana Hospital, Adana
Adana Numune Training and Research Hospital, Adana
Akdeniz University Medical Faculty, Antalya
Royal Cornwall Hospital, Truro
Royal Devon and Exeter Hospital (Wonford), Exeter
Derriford Hospital, Plymouth
Aberdeen Royal Infirmary, Aberdeen
Queen Mary University of London, London
University College London Hospitals, London
Sarah Cannon Research Institute UK, London
Western General Hospital, Edinburgh
Nottingham University Hospitals City Campus, Nottingham
Lead Sponsor
Collaborators (2)
Daiichi Sankyo Co., Ltd.
INDUSTRY
AstraZeneca
INDUSTRY
Daiichi Sankyo
INDUSTRY