VIdeo Assisted Thoracoscopic Lobectomy Versus Conventional Open LobEcTomy for Lung Cancer

NACompletedINTERVENTIONAL
Enrollment

503

Participants

Timeline

Start Date

July 31, 2015

Primary Completion Date

March 31, 2019

Study Completion Date

March 31, 2020

Conditions
Lung Neoplasms
Interventions
PROCEDURE

Open Surgery

Conventional open surgery is undertaken through a single incision +/- rib resection and with rib spreading. The operation is performed under direct vision with isolation of the hilar structures (vein, artery and bronchus) which are dissected, ligated and divided in sequence and the lobe of lung resected. The procedures may be undertaken using ligatures, over sewing or with staplers. Lymph node management is undertaken in accordance with the International Association of the Study of Lung Cancer (IASLC) recommendations where a minimal of 6 nodes / stations are removed, of which 3 are from the mediastinum that includes the subcarinal station. The thoracotomy is closed in layers starting from pericostal sutures over the ribs, muscle, fat and skin layers.

PROCEDURE

Video Assisted Thoracoscopic Surgery (VATS)

VATS lobectomy is undertaken through one to four keyhole incisions without rib spreading. The use of 'rib spreading' is prohibited as this is the key intra-operative manoeuvre which disrupts tissues and causes pain (and is used in open surgery). The procedure is performed with videoscopic visualisation without direct vision. The hilar structures are dissected, stapled and divided. Endoscopic ligation of pulmonary arterial branches may be performed. The fissure is completed and the lobe of lung resected. Lymph node management is the same as described for open surgery. The incisions are closed in layers and may involve muscle, fat and skin layers. This definition of VATS lobectomy is a modification of CALGB 39802.

Trial Locations (9)

Unknown

Heartlands Hospital, Birmingham

Bristol Royal Infirmary, Bristol

Royal Infirmary of Edinburgh, Edinburgh

Hull and East Yorkshire Hospitals NHS Trust, Hull

Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool

Harefield Hospital, London

Royal Brompton Hospital, London

The James Cook University Hospital, Middlesbrough

Oxford University Hospitals NHS Foundation Trust, Oxford

All Listed Sponsors
collaborator

Royal Brompton & Harefield NHS Foundation Trust

OTHER

collaborator

University of Oxford

OTHER

lead

University of Bristol

OTHER

NCT03521375 - VIdeo Assisted Thoracoscopic Lobectomy Versus Conventional Open LobEcTomy for Lung Cancer | Biotech Hunter | Biotech Hunter