503
Participants
Start Date
July 31, 2015
Primary Completion Date
March 31, 2019
Study Completion Date
March 31, 2020
Open Surgery
Conventional open surgery is undertaken through a single incision +/- rib resection and with rib spreading. The operation is performed under direct vision with isolation of the hilar structures (vein, artery and bronchus) which are dissected, ligated and divided in sequence and the lobe of lung resected. The procedures may be undertaken using ligatures, over sewing or with staplers. Lymph node management is undertaken in accordance with the International Association of the Study of Lung Cancer (IASLC) recommendations where a minimal of 6 nodes / stations are removed, of which 3 are from the mediastinum that includes the subcarinal station. The thoracotomy is closed in layers starting from pericostal sutures over the ribs, muscle, fat and skin layers.
Video Assisted Thoracoscopic Surgery (VATS)
VATS lobectomy is undertaken through one to four keyhole incisions without rib spreading. The use of 'rib spreading' is prohibited as this is the key intra-operative manoeuvre which disrupts tissues and causes pain (and is used in open surgery). The procedure is performed with videoscopic visualisation without direct vision. The hilar structures are dissected, stapled and divided. Endoscopic ligation of pulmonary arterial branches may be performed. The fissure is completed and the lobe of lung resected. Lymph node management is the same as described for open surgery. The incisions are closed in layers and may involve muscle, fat and skin layers. This definition of VATS lobectomy is a modification of CALGB 39802.
Heartlands Hospital, Birmingham
Bristol Royal Infirmary, Bristol
Royal Infirmary of Edinburgh, Edinburgh
Hull and East Yorkshire Hospitals NHS Trust, Hull
Liverpool Heart and Chest Hospital NHS Foundation Trust, Liverpool
Harefield Hospital, London
Royal Brompton Hospital, London
The James Cook University Hospital, Middlesbrough
Oxford University Hospitals NHS Foundation Trust, Oxford
Royal Brompton & Harefield NHS Foundation Trust
OTHER
University of Oxford
OTHER
University of Bristol
OTHER