A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors

PHASE1CompletedINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

July 10, 2018

Primary Completion Date

June 1, 2022

Study Completion Date

September 6, 2022

Conditions
MelanomaBreast CarcinomaHepatocellular CarcinomaUrothelial CarcinomaSquamous Cell Carcinoma of the Head and NeckRenal Cell CarcinomaColorectal CarcinomaNon-small Cell Lung CarcinomaGastric or Gastroesophageal Junction AdenocarcinomaEndometrial CarcinomaMesotheliomaNeuroendocrine CarcinomaCervical CancerSmall Cell Lung CarcinomaSquamous Cell Carcinoma of the AnusCastration-Resistant Prostate CarcinomaNasopharyngeal CarcinomaCholangiocarcinomaBasal Cell CarcinomaOvarian CarcinomaFallopian Tube CarcinomaThymomaThymic CarcinomaSquamous Cell Carcinoma of the PenisVulvar CarcinomaSolid Tumors With Published Evidence of Anti-tumor Activity With Anti-PD1/PDL1 and/or Anti-CTLA4-directed TherapyMalignant Adnexal NeoplasmsNon-squamous Cell Salivary Gland Carcinoma
Interventions
BIOLOGICAL

XmAb20717

Monoclonal bispecific antibody

Trial Locations (17)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10032

Columbia University Medical Center - Herbert Irving Pavilion, New York

15232

UPMC Hillman Cancer Center, Pittsburgh

19104

Hospital of the University of Pennsylvania, Philadelphia

22903

Emily Couric Clinical Cancer Center, Charlottesville

30322

Emory University, Atlanta

48201

Karmanos Cancer Institute, Detroit

60637

University of Chicago Medicine, Chicago

66205

The University of Kansas Clinical Research Center, Fairway

77030

The University of Texas MD Anderson Cancer Center, Houston

84112

University of Utah, Huntsman Cancer Institute, Salt Lake City

90048

Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles

90095

UCLA Hematology-Oncology Clinic (Westwood), Los Angeles

94115

University of California San Francisco Medical Center, San Francisco

97213

Providence Portland Medical Center, Portland

98109

Seattle Cancer Care Alliance, Seattle

92093-0698

University of California San Diego Moores Cancer Center, San Diego

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

ICON plc

INDUSTRY

lead

Xencor, Inc.

INDUSTRY