Pembrolizumab and Dasatinib, Imatinib Mesylate, or Nilotinib in Treating Patients With Chronic Myeloid Leukemia and Persistently Detectable Minimal Residual Disease

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

June 26, 2019

Primary Completion Date

August 31, 2028

Study Completion Date

August 31, 2031

Conditions
Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 PositiveMinimal Residual Disease
Interventions
DRUG

Dasatinib

Given PO

DRUG

Imatinib Mesylate

Given PO

OTHER

Laboratory Biomarker Analysis

Correlative studies

DRUG

Nilotinib

Given PO

BIOLOGICAL

Pembrolizumab

Given IV

Trial Locations (291)

10940

Garnet Health Medical Center, Middletown

16801

Geisinger Medical Group, State College

17044

Lewistown Hospital, Lewistown

17822

Geisinger Medical Center, Danville

17837

Geisinger Medical Oncology-Lewisburg, Lewisburg

17870

Geisinger Medical Oncology-Selinsgrove, Selinsgrove

17901

Geisinger Cancer Services-Pottsville, Pottsville

18201

Geisinger Medical Center-Cancer Center Hazleton, Hazleton

18510

Community Medical Center, Scranton

18711

Geisinger Wyoming Valley/Henry Cancer Center, Wilkes-Barre

19317

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

Delaware Clinical and Laboratory Physicians PA, Newark

Helen F Graham Cancer Center, Newark

Medical Oncology Hematology Consultants PA, Newark

19718

Christiana Care Health System-Christiana Hospital, Newark

19801

Christiana Care Health System-Wilmington Hospital, Wilmington

19945

Beebe South Coastal Health Campus, Frankford

19958

Beebe Medical Center, Lewes

19971

Beebe Health Campus, Rehoboth Beach

19973

TidalHealth Nanticoke / Allen Cancer Center, Seaford

21229

Saint Agnes Hospital, Baltimore

24112

Sovah Health Martinsville, Martinsville

26506

West Virginia University Healthcare, Morgantown

27534

Southeastern Medical Oncology Center-Goldsboro, Goldsboro

Wayne Memorial Hospital, Goldsboro

28328

Southeastern Medical Oncology Center-Clinton, Clinton

28546

Onslow Memorial Hospital, Jacksonville

Southeastern Medical Oncology Center-Jacksonville, Jacksonville

29316

Prisma Health Cancer Institute - Spartanburg, Boiling Springs

29325

Prisma Health Cancer Institute - Laurens, Clinton

29605

BI-LO Charities Children's Cancer Center, Greenville

Prisma Health Cancer Institute - Butternut, Greenville

Prisma Health Cancer Institute - Faris, Greenville

Prisma Health Greenville Memorial Hospital, Greenville

29615

Prisma Health Cancer Institute - Eastside, Greenville

29640

Prisma Health Cancer Institute - Easley, Easley

29650

Prisma Health Cancer Institute - Greer, Greer

29672

Prisma Health Cancer Institute - Seneca, Seneca

37067

Vanderbilt-Ingram Cancer Center Cool Springs, Franklin

37204

Vanderbilt Breast Center at One Hundred Oaks, Nashville

37232

Vanderbilt University/Ingram Cancer Center, Nashville

37343

Pulmonary Medicine Center of Chattanooga-Hixson, Hixson

37363

Memorial GYN Plus, Ooltewah

37404

Memorial Hospital, Chattanooga

40004

Flaget Memorial Hospital, Bardstown

40165

Jewish Hospital Medical Center South, Shepherdsville

40202

Jewish Hospital, Louisville

40215

Saints Mary and Elizabeth Hospital, Louisville

40245

UofL Health Medical Center Northeast, Louisville

40353

Saint Joseph Mount Sterling, Mount Sterling

40504

Saint Joseph Hospital, Lexington

Saint Joseph Radiation Oncology Resource Center, Lexington

40509

Saint Joseph Hospital East, Lexington

40701

Commonwealth Cancer Center-Corbin, Corbin

40741

Saint Joseph London, London

42003

Mercy Health - Paducah Medical Oncology and Hematology, Paducah

43537

Toledo Clinic Cancer Centers-Maumee, Maumee

43551

Mercy Health Perrysburg Cancer Center, Perrysburg

43623

Mercy Health - Saint Anne Hospital, Toledo

Toledo Clinic Cancer Centers-Toledo, Toledo

44109

MetroHealth Medical Center, Cleveland

45220

Good Samaritan Hospital - Cincinnati, Cincinnati

45242

Bethesda North Hospital, Cincinnati

45247

TriHealth Cancer Institute-Westside, Cincinnati

45255

TriHealth Cancer Institute-Anderson, Cincinnati

48162

Toledo Clinic Cancer Centers-Monroe, Monroe

49221

Hickman Cancer Center, Adrian

50010

Mary Greeley Medical Center, Ames

McFarland Clinic - Ames, Ames

50023

Mission Cancer and Blood - Ankeny, Ankeny

50036

McFarland Clinic - Boone, Boone

50129

McFarland Clinic - Jefferson, Jefferson

50158

McFarland Clinic - Marshalltown, Marshalltown

50266

Mercy Medical Center-West Lakes, West Des Moines

50309

Iowa Methodist Medical Center, Des Moines

Mission Cancer and Blood - Des Moines, Des Moines

50314

Broadlawns Medical Center, Des Moines

Mercy Medical Center - Des Moines, Des Moines

Mission Cancer and Blood - Laurel, Des Moines

50316

Iowa Lutheran Hospital, Des Moines

50325

Mercy Cancer Center-West Lakes, Clive

Mission Cancer and Blood - West Des Moines, Clive

50501

McFarland Clinic - Trinity Cancer Center, Fort Dodge

Trinity Regional Medical Center, Fort Dodge

50801

Greater Regional Medical Center, Creston

51401

Saint Anthony Regional Hospital, Carroll

51503

Alegent Health Mercy Hospital, Council Bluffs

53151

Froedtert and MCW Moorland Reserve Health Center, New Berlin

53226

Medical College of Wisconsin, Milwaukee

54401

Marshfield Clinic-Wausau Center, Wausau

54449

Marshfield Medical Center-Marshfield, Marshfield

54476

Marshfield Medical Center - Weston, Weston

54482

Marshfield Medical Center-River Region at Stevens Point, Stevens Point

54494

Marshfield Clinic - Wisconsin Rapids Center, Wisconsin Rapids

54548

Marshfield Clinic-Minocqua Center, Minocqua

54701

Marshfield Medical Center-EC Cancer Center, Eau Claire

Mayo Clinic Health System-Eau Claire Clinic, Eau Claire

54703

Mayo Clinic Health System Eau Claire Hospital-Luther Campus, Eau Claire

54848

Marshfield Medical Center - Ladysmith, Ladysmith

54868

Marshfield Medical Center-Rice Lake, Rice Lake

54911

ThedaCare Regional Cancer Center, Appleton

55905

Mayo Clinic in Rochester, Rochester

56303

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud

59101

Billings Clinic Cancer Center, Billings

59405

Benefis Sletten Cancer Institute, Great Falls

Great Falls Clinic, Great Falls

59601

Saint Peter's Community Hospital, Helena

59711

Community Hospital of Anaconda, Anaconda

59715

Bozeman Health Deaconess Hospital, Bozeman

59804

Community Medical Center, Missoula

59901

Kalispell Regional Medical Center, Kalispell

60045

Northwestern Medicine Lake Forest Hospital, Lake Forest

60504

Rush - Copley Medical Center, Aurora

60560

Rush-Copley Healthcare Center, Yorkville

60611

Northwestern University, Chicago

60612

University of Illinois, Chicago

61021

Illinois CancerCare-Dixon, Dixon

61350

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

Illinois CancerCare-Peru, Peru

Valley Radiation Oncology, Peru

61356

Illinois CancerCare-Princeton, Princeton

61401

Illinois CancerCare-Galesburg, Galesburg

Western Illinois Cancer Treatment Center, Galesburg

61443

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

Illinois CancerCare-Macomb, Macomb

61520

Illinois CancerCare-Canton, Canton

61530

Illinois CancerCare-Eureka, Eureka

61554

Illinois CancerCare-Pekin, Pekin

61571

Illinois CancerCare - Washington, Washington

61615

Illinois CancerCare-Peoria, Peoria

61636

Methodist Medical Center of Illinois, Peoria

61704

Illinois CancerCare-Bloomington, Bloomington

61801

Carle Cancer Center, Urbana

The Carle Foundation Hospital, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62002

Saint Anthony's Health, Alton

62226

Southwest Illinois Health Services LLP, Swansea

62269

Cancer Care Center of O'Fallon, O'Fallon

62321

Illinois CancerCare-Carthage, Carthage

62401

Carle Physician Group-Effingham, Effingham

Crossroads Cancer Center, Effingham

62526

Cancer Care Specialists of Illinois - Decatur, Decatur

Decatur Memorial Hospital, Decatur

62702

Southern Illinois University School of Medicine, Springfield

Springfield Clinic, Springfield

62781

Memorial Medical Center, Springfield

62801

Centralia Oncology Clinic, Centralia

Saint Mary's Hospital, Centralia

62864

Good Samaritan Regional Health Center, Mount Vernon

62902

Memorial Hospital of Carbondale, Carbondale

62918

SIH Cancer Institute, Carterville

63011

Saint Louis Cancer and Breast Institute-Ballwin, Ballwin

63017

Saint Luke's Hospital, Chesterfield

63080

Missouri Baptist Sullivan Hospital, Sullivan

63090

Mercy Hospital Washington, Washington

63109

Saint Louis Cancer and Breast Institute-South City, St Louis

63127

BJC Outpatient Center at Sunset Hills, Sunset Hills

63128

Mercy Hospital South, St Louis

63131

Missouri Baptist Medical Center, St Louis

63141

Mercy Hospital Saint Louis, St Louis

63628

Parkland Health Center-Bonne Terre, Bonne Terre

63640

Parkland Health Center - Farmington, Farmington

63670

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

Saint Francis Medical Center, Cape Girardeau

Southeast Cancer Center, Cape Girardeau

64506

Heartland Regional Medical Center, Saint Joseph

64804

Freeman Health System, Joplin

Mercy Hospital Joplin, Joplin

65065

Lake Regional Hospital, Osage Beach

65109

MU Health Care Goldschmidt Cancer Center, Jefferson City

65401

Delbert Day Cancer Institute at PCRMC, Rolla

Mercy Clinic-Rolla-Cancer and Hematology, Rolla

65613

Central Care Cancer Center - Bolivar, Bolivar

65616

Cox Cancer Center Branson, Branson

65804

Mercy Hospital Springfield, Springfield

65807

CoxHealth South Hospital, Springfield

66044

Lawrence Memorial Hospital, Lawrence

67208

Cancer Center of Kansas-Wichita Medical Arts Tower, Wichita

67214

Ascension Via Christi Hospitals Wichita, Wichita

Cancer Center of Kansas - Wichita, Wichita

Wesley Medical Center, Wichita

67530

Central Care Cancer Center - Great Bend, Great Bend

67846

Central Care Cancer Center - Garden City, Garden City

68046

Midlands Community Hospital, Papillion

68118

Nebraska Medicine-Village Pointe, Omaha

68122

Alegent Health Immanuel Medical Center, Omaha

Hematology and Oncology Consultants PC, Omaha

68123

Nebraska Medicine-Bellevue, Bellevue

68124

Alegent Health Bergan Mercy Medical Center, Omaha

68130

Alegent Health Lakeside Hospital, Omaha

68131

Creighton University Medical Center, Omaha

68198

University of Nebraska Medical Center, Omaha

68510

Saint Elizabeth Regional Medical Center, Lincoln

68803

Nebraska Cancer Specialists/Oncology Hematology West PC, Grand Island

68845

Heartland Hematology and Oncology, Kearney

68847

CHI Health Good Samaritan, Kearney

71913

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs

72205

CARTI Cancer Center, Little Rock

72903

Mercy Hospital Fort Smith, Fort Smith

73104

University of Oklahoma Health Sciences Center, Oklahoma City

73120

Mercy Hospital Oklahoma City, Oklahoma City

73505

Cancer Centers of Southwest Oklahoma Research, Lawton

74146

Oklahoma Cancer Specialists and Research Institute-Tulsa, Tulsa

77802

Saint Joseph Regional Cancer Center, Bryan

80012

Rocky Mountain Cancer Centers-Aurora, Aurora

80112

Rocky Mountain Cancer Centers - Centennial, Centennial

80113

Mountain Blue Cancer Care Center - Swedish, Englewood

Rocky Mountain Cancer Centers - Swedish, Englewood

Swedish Medical Center, Englewood

The Melanoma and Skin Cancer Institute, Englewood

80120

Rocky Mountain Cancer Centers-Littleton, Littleton

80122

Littleton Adventist Hospital, Littleton

80124

Rocky Mountain Cancer Centers-Sky Ridge, Lone Tree

80138

Parker Adventist Hospital, Parker

Rocky Mountain Cancer Centers-Parker, Parker

80209

The Women's Imaging Center, Denver

80210

Porter Adventist Hospital, Denver

80218

Colorado Blood Cancer Institute, Denver

Presbyterian - Saint Lukes Medical Center - Health One, Denver

Rocky Mountain Cancer Centers-Midtown, Denver

80220

Rocky Mountain Cancer Centers-Rose, Denver

Rose Medical Center, Denver

80228

Rocky Mountain Cancer Centers-Lakewood, Lakewood

Saint Anthony Hospital, Lakewood

80260

Rocky Mountain Cancer Centers-Thornton, Thornton

80303

Boulder Community Foothills Hospital, Boulder

80304

Rocky Mountain Cancer Centers-Boulder, Boulder

80401

Mountain Blue Cancer Care Center, Golden

80501

Longmont United Hospital, Longmont

Rocky Mountain Cancer Centers-Longmont, Longmont

80907

Penrose-Saint Francis Healthcare, Colorado Springs

Rocky Mountain Cancer Centers-Penrose, Colorado Springs

80923

Saint Francis Cancer Center, Colorado Springs

81004

Saint Mary Corwin Medical Center, Pueblo

81008

Rocky Mountain Cancer Centers - Pueblo, Pueblo

81301

Mercy Medical Center, Durango

Southwest Oncology PC, Durango

82001

Cheyenne Regional Medical Center-West, Cheyenne

82414

Billings Clinic-Cody, Cody

82801

Welch Cancer Center, Sheridan

83605

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83617

Walter Knox Memorial Hospital, Emmett

83642

Idaho Urologic Institute-Meridian, Meridian

83687

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85004

Cancer Center at Saint Joseph's, Phoenix

85338

CTCA at Western Regional Medical Center, Goodyear

93401

Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo

93420

Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande

93444

Mission Hope Medical Oncology - Santa Maria, Santa Maria

94598

BASS Medical Group - Lennon, Walnut Creek

95340

Mercy Cancer Center, Merced

95608

Mercy Cancer Center - Carmichael, Carmichael

Mercy San Juan Medical Center, Carmichael

95695

Woodland Memorial Hospital, Woodland

95758

Mercy Cancer Center - Elk Grove, Elk Grove

95765

Mercy Cancer Center - Rocklin, Rocklin

95816

Mercy Cancer Center - Sacramento, Sacramento

97814

Saint Alphonsus Cancer Care Center-Baker City, Baker City

97914

Saint Alphonsus Cancer Care Center-Ontario, Ontario

98003

Saint Francis Hospital, Federal Way

98022

Saint Elizabeth Hospital, Enumclaw

98166

Highline Medical Center-Main Campus, Burien

98310

Harrison HealthPartners Hematology and Oncology-Bremerton, Bremerton

98368

Jefferson Healthcare, Port Townsend

98370

Harrison HealthPartners Hematology and Oncology-Poulsbo, Poulsbo

98383

Saint Michael Cancer Center, Silverdale

98405

Franciscan Research Center-Northwest Medical Plaza, Tacoma

Northwest Medical Specialties PLLC, Tacoma

98499

Saint Clare Hospital, Lakewood

99701

Fairbanks Memorial Hospital, Fairbanks

94553-3156

Contra Costa Regional Medical Center, Martinez

06418

Smilow Cancer Hospital-Derby Care Center, Derby

06824

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06033

Smilow Cancer Hospital Care Center at Glastonbury, Glastonbury

06437

Smilow Cancer Hospital Care Center - Guilford, Guilford

06105

Smilow Cancer Hospital Care Center at Saint Francis, Hartford

06510

Smilow Cancer Center/Yale-New Haven Hospital, New Haven

06520

Yale University, New Haven

06473

Yale-New Haven Hospital North Haven Medical Center, North Haven

06790

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

Smilow Cancer Hospital Care Center - Waterford, Waterford

50266-7700

Methodist West Hospital, West Des Moines

07960

Morristown Medical Center, Morristown

07902

Overlook Hospital, Summit

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

ECOG-ACRIN Cancer Research Group

NETWORK